公开(公告)号：US06750962B2

公开(公告)日：2004-06-15

申请号：US09828874

申请日：2001-04-10

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

IPC分类号： G01N110

CPC分类号： G01N21/8483

摘要： A multi-use assay system accurately docks a removable test strip supporting a reagent-analyte reaction with an optics system including an LED, photodetector, and lenses or light pipes for directing light to and from the test strip. Docking is achieved using alignment fixturing, whereby an optics block holder is relied upon to align the test strip and test pad with the various optical components. Signals from the photodetector indicative of test strip reaction progress are provided to a processor for measuring the analyte.

摘要翻译： 多用分析系统将包含LED，光电检测器和透镜或光管的光学系统的支撑试剂 - 分析物反应的可移除测试条准确地对准，以将光导向和从测试条引导。 使用对准夹具实现对接，由此依靠光学块保持器将测试条和测试垫与各种光学部件对准。 来自光电检测器的指示测试条反应进程的信号被提供给用于测量分析物的处理器。

公开(公告)号：US06285454B1

公开(公告)日：2001-09-04

申请号：US09206641

申请日：1998-12-07

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John E. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John E. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

IPC分类号： G01N110

CPC分类号： G01N21/8483

摘要： A multi-use assay system accurately docks a removable test strip supporting a reagent-analyte reaction with an optics system including an LED, photodetector, and lenses or light pipes for directing light to and from the test strip. Docking is achieved using alignment fixturing, whereby an optics block holder is relied upon to align the test strip and test pad with the various optical components. Signals from the photodetector indicative of test strip reaction progress are provided to a processor for measuring the analyte.

摘要翻译： 多用分析系统将包含LED，光电检测器和透镜或光管的光学系统的支撑试剂 - 分析物反应的可移除测试条准确地对准，以将光导向和从测试条引导。 使用对准夹具实现对接，由此依靠光学块保持器将测试条和测试垫与各种光学部件对准。 来自光电检测器的指示测试条反应进程的信号被提供给用于测量分析物的处理器。

公开(公告)号：US06780651B2

公开(公告)日：2004-08-24

申请号：US09875297

申请日：2001-06-07

申请人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

发明人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

IPC分类号： G01N33543

CPC分类号： G01N33/521 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： A method of making strip for testing for the presence of an analyte generally comprises providing a support member which includes a spreading layer and a reagent layer, and a capillary in communication with the support layer and spreading layer for transporting a sample of body fluid thereto.

摘要翻译： 制造用于测试分析物存在的条带的方法通常包括提供包括扩散层和试剂层的支撑构件，以及与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。

公开(公告)号：USD403975S

公开(公告)日：1999-01-12

申请号：US72445

申请日：1997-06-17

申请人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

设计人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

公开(公告)号：US5948695A

公开(公告)日：1999-09-07

申请号：US874468

申请日：1997-06-17

申请人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

发明人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

IPC分类号： G01N31/22 ,  B01L3/00 ,  G01N33/52 ,  G01N33/543

CPC分类号： G01N33/521 ,  B01L3/5023 ,  G01N33/525 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： A strip for testing for the presence of an analyte generally comprises a support member which contains a spreading layer and a reagent layer, and a capillary tube in communication with the support layer and spreading layer for transporting a sample of body fluid thereto. A method of testing a fluid for the presence or concentration of an analyte is also provided which generally includes providing a test strip with a support member, a spreading layer, and a reagent layer on the spreading layer. A capillary tube is provided on the support member whereby a fluid containing an analyte to be tested is introduced into the tube and flows through the tube to the spreading layer and contacts the reagent layer.

摘要翻译： 用于测试分析物存在的条带通常包括包含扩展层和试剂层的支撑构件和与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。 还提供了测试流体用于分析物的存在或浓度的方法，其通常包括在扩散层上提供具有支撑构件，扩散层和试剂层的测试条。 毛细管设置在支撑构件上，由此将含有要测试的被分析物的流体引入到管中并流过管到扩散层并与试剂层接触。

公开(公告)号：US06271045B1

公开(公告)日：2001-08-07

申请号：US09306994

申请日：1999-05-07

申请人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

发明人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

IPC分类号： G01N33543

CPC分类号： G01N33/521 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： A strip for testing for the presence of an analyte generally comprises a support member which contains a spreading layer and a reagent layer, and a capillary tube in communication with the support layer and spreading layer for transporting a sample of body fluid thereto. A method of testing a fluid for the presence or concentration of an analyte is also provided which generally includes providing a test strip with a support member, a spreading layer, and a reagent layer on the spreading layer. A capillary tube is provided on the support member whereby a fluid containing an analyte to be tested is introduced into the tube and flows through the tube to the spreading layer and contacts the reagent layer.

摘要翻译： 用于测试分析物存在的条带通常包括包含扩展层和试剂层的支撑构件和与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。 还提供了测试流体用于分析物的存在或浓度的方法，其通常包括在扩散层上提供具有支撑构件，扩散层和试剂层的测试条。 毛细管设置在支撑构件上，由此将含有要测试的被分析物的流体引入到管中并流过管到扩散层并与试剂层接触。

公开(公告)号：US6001239A

公开(公告)日：1999-12-14

申请号：US164405

申请日：1998-09-30

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  G01N27/26

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

公开(公告)号：US06582573B2

公开(公告)日：2003-06-24

申请号：US09878774

申请日：2001-06-08

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： G01N27327

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

摘要翻译： 提供电化学测试装置，用于确定含水流体样品中分析物的存在或浓度。 电化学测试装置包括工作电极和由非晶半导体材料制成的对电极。 工作电极与能够与分析物反应的试剂重叠，以产生可测量的电位变化，其可以与流体样品中分析物的浓度相关。 测试装置可选地包含由在参考电极上具有参考材料的非晶半导体材料制成的参考电极。

公开(公告)号：US06245215B1

公开(公告)日：2001-06-12

申请号：US09401062

申请日：1999-09-22

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： G01N2726

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

摘要翻译： 提供电化学测试装置，用于确定含水流体样品中分析物的存在或浓度。 电化学测试装置包括工作电极和由非晶半导体材料制成的对电极。 工作电极与能够与分析物反应的试剂重叠，以产生可测量的电位变化，其可以与流体样品中分析物的浓度相关。 测试装置可选地包含由在参考电极上具有参考材料的非晶半导体材料制成的参考电极。