摘要:
The present technology provides novel anhydrous and hydrated crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea, amorphous and anhydrous crystalline polymorphs of its monophosphoric acid salt, and the hydrochloride salt, including its dihydrate. The present technology further provides methods for preparing the various forms, compositions containing them, and methods of treatment employing them.
摘要:
The present technology provides novel anhydrous and hydrated crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea, amorphous and anhydrous crystalline polymorphs of its monophosphoric acid salt, and the hydrochloride salt, including its dihydrate. The present technology further provides methods for preparing the various forms, compositions containing them, and methods of treatment employing them.
摘要:
The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
摘要:
The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.
摘要:
The invention provides a method of forming a T-shaped pipe (60) or tube connecting section, also referred to as a T-connector, T-junction or a T-section. The method comprises the step of cutting a form out of sheet metal, the form substantially comprising a rectangle having extensions on each side arranged in two pairs of opposing extensions (2) followed by the step of bending the edges of a first pair of opposing extensions (6a, 6b) together to form a body having a central passage extending through the body in a first plane and a further passage (64) extending from the exterior of the body to the central passage in a plane orthogonal to the first plane. The invention also provides apparatus arranged to form a T-connector.
摘要:
A cable hook includes attachment means with a substantially base having a plantar bottom surface. The hook portion extends upwardly from the base (17) and includes upper and lower jaws (21, 23) with a lateral opening that is substantially circular. A single, laterally-extending notch (20) is located on the inside surface of the upper jaw proximate a frontal opening (22) between the jaws. Orientation marks (12) are included on the bottom surface of the base (17). Panel attachment means (18) are preferably deformer undercut grooves (16) for receiving the cold flow of metal from a metal panel (19) attached thereby. The hook (10) may be used to secure cables, a spring, a rod, tubing, or shaft.
摘要:
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.