公开(公告)号：US20100056874A1

公开(公告)日：2010-03-04

申请号：US12515383

申请日：2007-11-06

申请人： Johan Frederik Dijksman ,  Frits Tobi De Jongh ,  Michel Gerardus Pardoel ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Remus Albu ,  Ventzeslav Iordanov ,  Hans Marc Bert Boeve

发明人： Johan Frederik Dijksman ,  Frits Tobi De Jongh ,  Michel Gerardus Pardoel ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Remus Albu ,  Ventzeslav Iordanov ,  Hans Marc Bert Boeve

IPC分类号： A61M31/00 ,  A61B5/00

CPC分类号： A61M5/14593 ,  A61B1/041 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/4839 ,  A61M5/14276 ,  A61M31/002 ,  A61M2005/14204 ,  A61M2205/3561

摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

摘要翻译： 一种药物输送装置，其包括驱动机构和具有储存器（2）的壳体（1），其至少部分地填充有物质，并且至少在一侧上用柔性壁（21）密封。 驱动机构适于将活塞（23）压靠在柔性壁（21）上，从而通过储存器（2）中的开口（25）将物质从储存器（2）释放。 这提供了一种安全可靠的药物输送装置。

公开(公告)号：US09878094B2

公开(公告)日：2018-01-30

申请号：US12515383

申请日：2007-11-06

申请人： Johan Frederik Dijksman ,  Frits Tobi De Jongh ,  Michel Gerardus Pardoel ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Remus Albu ,  Ventzeslav Iordanov ,  Hans Marc Bert Boeve

发明人： Johan Frederik Dijksman ,  Frits Tobi De Jongh ,  Michel Gerardus Pardoel ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Remus Albu ,  Ventzeslav Iordanov ,  Hans Marc Bert Boeve

IPC分类号： A61M31/00 ,  A61B5/00 ,  A61M5/145 ,  A61B5/07 ,  A61B5/145 ,  A61B1/04 ,  A61B5/01 ,  A61M5/142

CPC分类号： A61M5/14593 ,  A61B1/041 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/4839 ,  A61M5/14276 ,  A61M31/002 ,  A61M2005/14204 ,  A61M2205/3561

摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

公开(公告)号：US08374817B2

公开(公告)日：2013-02-12

申请号：US12594244

申请日：2008-03-27

申请人： Hans Marc Bert Boeve ,  Teunis Jan Ikkink ,  Haris Duric

发明人： Hans Marc Bert Boeve ,  Teunis Jan Ikkink ,  Haris Duric

IPC分类号： G01C17/38

CPC分类号： G01C17/38

摘要： An electronic device has an orientation sensing system for determining an orientation of the device. The system includes a magnetometer and an accelerometer. The system further has a calibration device configured to calibrate the sensing system for operational use. The accelerometer supplies measurements used to constrain a range of possible directions of the external magnetic field to be determined. The calibration device numerically solves a set of equations and is equally usable for a 2D or 3D magnetometer in combination with a 2D or 3D accelerometer.

摘要翻译： 电子设备具有用于确定设备的取向的定向感测系统。 该系统包括磁力计和加速度计。 该系统还具有被配置为校准感测系统以用于操作使用的校准装置。 加速度计提供用于限制要确定的外部磁场的可能方向的范围的测量。 校准装置以数字方式解决一组方程式，并且可与2D或3D加速度计结合使用的二维或三维磁强计同样适用。

公开(公告)号：US08134881B2

公开(公告)日：2012-03-13

申请号：US12765897

申请日：2010-04-23

申请人： Hans Marc Bert Boeve

发明人： Hans Marc Bert Boeve

IPC分类号： G11C7/02 ,  G11C7/04

CPC分类号： G11C7/04 ,  G11C7/14 ,  G11C11/16 ,  G11C16/28 ,  G11C16/3418 ,  G11C16/3431

摘要： A non volatile memory device comprises memory cells such as MRAM cells, reading circuits and a reference cell for generating a reference for use by the reading circuits, and can determine if the reference is degraded by thermal instability. This can help reduce a data error rate. Detecting such degradation can prove to be more effective than trying to design in enough margins for the lifetime of the device. The reference cell can be less susceptible to degradation than other cells by using different shape of cells and different write currents. Where each reference cell is used by many memory cells, the reference cell tends to be used more often than any particular memory cell and so can be more susceptible to degradation. Another way of ensuring against longer term degradation of the reference is periodically rewriting the reference cell.

摘要翻译： 非易失性存储器件包括诸如MRAM单元，读取电路和用于产生读取电路使用的参考的参考单元的存储单元，并且可以确定引用是否因热不稳定性而劣化。 这可以帮助减少数据错误率。 检测这种劣化可以证明比在设备寿命期间设计足够的余量更有效。 通过使用不同形状的电池和不同的写入电流，参考电池可以比其他电池更不易于劣化。 在每个参考单元被许多存储器单元使用的情况下，参考单元倾向于比任何特定存储单元更频繁地使用，因此可能更容易劣化。 确保参考的长期退化的另一种方法是定期重写参考单元。

公开(公告)号：US20120058441A1

公开(公告)日：2012-03-08

申请号：US13319351

申请日：2010-04-19

申请人： Hans Marc Bert Boeve

发明人： Hans Marc Bert Boeve

IPC分类号： F24J3/00

CPC分类号： A61B5/05 ,  A61B5/0515 ,  A61N1/403 ,  A61N2/02 ,  G01R33/1276

摘要： The present invention relates to an arrangement (10) for heating of a magnetic material (100) located in the centre region of an inscribed sphere within a region of action, which arrangement comprises:—selection means (210) for generating a magnetic selection field (211) having a pattern in space of its magnetic field strength such that a first sub-zone (301) having a low magnetic field strength and a second sub-zone (302) having a higher magnetic field strength are formed in the region of action (300),—drive means (220) for changing the position in space of the two sub-zones (301, 302) in the region of action (300) by means of a magnetic drive field (221) so that the magnetization of the magnetic material (100) changes locally, and—control means (76) for controlling the drive means (220) to change the position in space of the first sub-zone (301) along a sequence of locations around said inscribed sphere for so long and with such a frequency that the centre region of said inscribed sphere is heated.

摘要翻译： 本发明涉及一种用于加热位于动作区域内的内接球的中心区域的磁性材料（100）的装置（10），该装置包括：选择装置（210），用于产生选磁场 （211）具有其磁场强度的空间中的图案，使得具有较低磁场强度的第一子区（301）和具有较高磁场强度的第二子区（302）形成在 动作（300）， - 驱动装置（220），用于通过磁驱动场（221）改变动作区域（300）中的两个子区域（301,302）的空间位置，使得磁化 磁性材料（100）局部变化的控制装置（76），用于控制驱动装置（220）沿着所述内接球体周围的位置序列改变第一子区域（301）的空间位置，以便 这么长的时间，就像这样一个频率，就是那个里面的中心区域 床球加热。

公开(公告)号：US08014192B2

公开(公告)日：2011-09-06

申请号：US10536291

申请日：2003-11-06

申请人： Gavin Nicholas Phillips ,  Hans Marc Bert Boeve

发明人： Gavin Nicholas Phillips ,  Hans Marc Bert Boeve

IPC分类号： G11C11/00

CPC分类号： G11C11/16 ,  G11C29/50 ,  G11C2029/5002

摘要： Reference magnetic elements or bits with a range of magnetic volumes smaller than the minimum size used for actual data storage are written or patterned in the data storage device. The reference elements or bits have dimensions such that their magnetization will relax in a shorter time than that of the minimum expected relaxation time of the storage elements or bits. Probing of the magnetization of the reference elements or bits allows the detection of the probable onset of magnetization relaxation in the storage elements or bits therefore signaling that the re-writing (re-magnetizing) of the storage elements or bits is necessary. Such a scheme can be organized over rows, columns, or sectors.

摘要翻译： 在数据存储装置中写入或图案化具有小于用于实际数据存储的最小尺寸的磁体积范围的参考磁性元件或位。 参考元件或位具有使得它们的磁化在比存储元件或位的最小预期松弛时间更短的时间内松弛的尺寸。 探测参考元件或位的磁化允许检测存储元件或位中磁化松弛的可能开始，从而表明存储元件或位的重写（重新磁化）是必要的。 这样的方案可以按行，列或扇区进行组织。

公开(公告)号：US20100259251A1

公开(公告)日：2010-10-14

申请号：US12746607

申请日：2008-12-09

申请人： Hans Marc Bert Boeve

发明人： Hans Marc Bert Boeve

IPC分类号： G01R33/12

CPC分类号： A61B5/05 ,  A61B5/0515 ,  A61N1/403 ,  A61N2/02 ,  A61N2/06

摘要： An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises:—selection means (210) for generating a magnetic selection field (211) having a pattern in space of its magnetic field strength such that a first sub-zone (301) having a low magnetic field strength and a second sub-zone (302) having a higher magnetic field strength are formed in the region of action (300),—drive means (220) for changing the position in space of the two sub-zones (301, 302) in the region of action (300) by means of a magnetic drive field (221) so that the magnetization of the magnetic particles (100) changes locally,—receiving means (230) for acquiring signals, which signals depend on the magnetization in the region of action (300), which magnetization is influenced by the change in the position in space of the first and second sub-zone (301, 302),—a control unit (11) for controlling the drive means and/or the selection means and/or the receiving means in such a way that—in a first mode of operation, the position in space of the two sub-zones is changed at a first frequency, and—in a second mode of operation, the position in space of the two sub-zones is changed at a second frequency, the second frequency being at least twice as high as the first frequency.

摘要翻译： 公开了一种用于影响和/或检测动作区域中的磁性颗粒的装置和方法，该装置包括： - 选择装置（210），用于产生具有其磁场强度空间中的图案的磁选择场（211） 使得具有低磁场强度的第一子区域（301）和具有较高磁场强度的第二子区域（302）形成在动作区域（300）中， - 驱动装置（220），用于改变 通过磁驱动场（221）在动作区域（300）中的两个子区域（301,302）的空间中的位置，使得磁性颗粒（100）的磁化局部变化， - 接收装置 （230），用于获取所述信号，所述信号取决于所述动作区域（300）中的磁化，所述磁化受到所述第一和第二子区域（301,302）的空间位置的变化的影响， - 控制单元（11），用于控制驱动装置和/或选择 装置和/或接收装置，使得在第一操作模式中，两个子区域的空间中的位置以第一频率改变，并且在第二操作模式中，在空间中的位置 两个子区域以第二频率改变，第二频率至少是第一频率的两倍。

公开(公告)号：US07635993B2

公开(公告)日：2009-12-22

申请号：US11596791

申请日：2005-05-11

申请人： Hans Marc Bert Boeve

发明人： Hans Marc Bert Boeve

IPC分类号： G11C11/15

CPC分类号： G11C11/15 ,  G01R15/205 ,  G01R33/09 ,  G01R33/098 ,  Y10T29/49002

摘要： A sensor for sensing magnetic field strength has a sensor element, and detection circuitry for detecting a level of resistance of the sensor element, the level of resistance varying with magnetic field under test and having hysteresis, so that upon electromagnetic excitation the resistance can switch between two or more stable levels as the magnetic field under test varies. The sensor outputs a digital signal according to the level of resistance. The sensor output may further be interpreted in terms of a change-of-state upon electromagnetic excitation. As the sensor no longer needs a different characteristic from magnetic memory cells, it can be much easier to construct and to integrate with magnetic memory cells than an analog sensor. An excitation signal varies a threshold for the magnetic field under test at which the resistance switches, to enable multiple measurements with different thresholds. Multiple sensor elements can have different thresholds, by having differing geometry or size. It has applications in current sensing, and programmable magnetic logic, when multiple input currents are sensed. Changing the threshold can change the logic operation between AND and OR.

摘要翻译： 用于感测磁场强度的传感器具有传感器元件，以及用于检测传感器元件的电阻水平的检测电路，电阻值随着测试中的磁场而变化并具有迟滞，从而在电磁激励时，电阻可以在 随着被测磁场的变化，两个或更多个稳定的水平。 传感器根据电阻水平输出数字信号。 传感器输出可以进一步根据电磁激励时的状态变化来解释。 由于传感器不再需要与磁存储单元不同的特性，因此与模拟传感器相比，可以轻松构建和集成磁存储单元。 激励信号改变电阻开关处的被测磁场的阈值，以便能够以不同的阈值进行多次测量。 多个传感器元件可以具有不同的阈值，具有不同的几何形状或尺寸。 当感应到多个输入电流时，它具有电流检测和可编程磁逻辑的应用。 更改阈值可以改变AND和OR之间的逻辑运算。

公开(公告)号：US20110316526A1

公开(公告)日：2011-12-29

申请号：US13203505

申请日：2010-03-01

申请人： Giovanni Nisato ,  Hans Marc Bert Boeve

发明人： Giovanni Nisato ,  Hans Marc Bert Boeve

IPC分类号： G01R35/00

CPC分类号： A61B5/05 ,  A61B5/0515 ,  G01R33/1215

摘要： The present invention relates to an arrangement (10) for measuring small amounts of a first medium (202) in a third medium (206) and/or of a substance in the first medium (202), said third medium (206) comprising said first medium (202) and a second medium (204), said second medium (204) comprising a known concentration of a magnetic material, wherein said arrangement comprises: magnetization means (12) for providing a variable magnetic field (20) in a region of action (22), in which a probe (18; 208) of said third medium (206) is placed for measurement, receiving means (14) for acquiring a detection signal of the magnetization of said probe (12) in said region of action (22) after application of said variable magnetic field (20), and evaluation means (214) for evaluating said detection signal and comparing it to calibration measurements of the magnetization of at least one calibration sample to derive an information about the amount of said first medium (202) in said third medium (206) and/or of said substance in said first medium (202).

摘要翻译： 本发明涉及一种用于测量第三介质（206）和/或第一介质（202）中的物质的少量第一介质（202）的装置（10），所述第三介质（206）包括 第一介质（202）和第二介质（204），所述第二介质（204）包括已知浓度的磁性材料，其中所述装置包括：用于在区域中提供可变磁场（20）的磁化装置（12） 的动作（22），其中放置所述第三介质（206）的探针（18; 208）用于测量;接收装置（14），用于在所述区域中获取所述探针（12）的磁化的检测信号， 在施加所述可变磁场（20）之后的动作（22）以及用于评估所述检测信号并将其与至少一个校准样本的磁化的校准测量值进行比较的评估装置（214），以得到关于所述可变磁场 所述第三介质（206）中的第一介质（202） ）和/或所述物质在所述第一介质（202）中。

公开(公告)号：US20110182821A1

公开(公告)日：2011-07-28

申请号：US12674444

申请日：2008-08-28

申请人： Holger Gruell ,  Hans Marc Bert Boeve ,  Denis Markov

发明人： Holger Gruell ,  Hans Marc Bert Boeve ,  Denis Markov

IPC分类号： A61K49/06 ,  A61K49/18 ,  B29C31/10

CPC分类号： A61K49/1812 ,  A61K49/1887 ,  B82Y5/00

摘要： The invention provides a magnetic tracer material for use in magnetic particle imaging and a manufacturing method thereof. The magnetic tracer material comprises clusters of a plurality of magnetic particles that are clustered in a controlled way to form individual entities, for example, stabilized oil droplets, solid emulsion particles, liposomes, polymersomes or vesicles, or naturally occurring biological entities such as cells or viruses.

摘要翻译： 本发明提供一种用于磁性粒子成像的磁性跟踪材料及其制造方法。 磁性示踪剂材料包含多个磁性颗粒的簇，其以受控的方式聚集以形成单个实体，例如稳定的油滴，固体乳液颗粒，脂质体，聚合物囊泡或囊泡，或天然存在的生物实体，例如细胞或 病毒