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公开(公告)号：US09157907B2
公开(公告)日：2015-10-13
申请号：US13695423
申请日：2011-04-27
Applicant: Johannes Grillari , Regina Grillari , Otto Kanzler
Inventor： Johannes Grillari , Regina Grillari , Otto Kanzler
CPC classification number: G01N33/5044 , C40B50/00 , G01N33/5014
Abstract: Panels of mammalian cell samples, kits and methods of use thereof. The panels comprise samples or sets of samples of immortalized primary cells, obtained from different tissues and organs of healthy and/or diseased donors. The cell panels are useful in assays for testing effects of drug candidates, e.g. for activity and toxicity.
Abstract translation: 哺乳动物细胞样品组，试剂盒及其使用方法。 该组包括从健康和/或患病供体的不同组织和器官获得的永生化原代细胞样品或组的样品。 细胞板可用于药物候选物的测试效果的测定，例如 用于活动和毒性。
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公开(公告)号：US20130045892A1
公开(公告)日：2013-02-21
申请号：US13695423
申请日：2011-04-27
Applicant: Johannes Grillari , Regina Grillari , Otto Kanzler
Inventor： Johannes Grillari , Regina Grillari , Otto Kanzler
CPC classification number: G01N33/5044 , C40B50/00 , G01N33/5014
Abstract: Panels of mammalian cell samples, kits and methods of use thereof. The panels comprise samples or sets of samples of immortalized primary cells, obtained from different tissues and organs of healthy and/or diseased donors. The cell panels are useful in assays for testing effects of drug candidates, e.g. for activity and toxicity.
Abstract translation: 哺乳动物细胞样品组，试剂盒及其使用方法。 该组包括从健康和/或患病供体的不同组织和器官获得的永生化原代细胞样品或组的样品。 细胞板可用于药物候选物的测试效果的测定，例如 用于活动和毒性。
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Patent Agency Ranking
公开(公告)号：US20130210883A1
公开(公告)日：2013-08-15
申请号：US13841530
申请日：2013-03-15
Applicant: Johannes Grillari , Rolf Breinbauer , Martina Schweiger , Matthias Romauch , Robert Zimmermann , Nicole Mayer , Elisabeth Schraml , Klaus Fortschegger , Regina Grillari
Inventor： Johannes Grillari , Rolf Breinbauer , Martina Schweiger , Matthias Romauch , Robert Zimmermann , Nicole Mayer , Elisabeth Schraml , Klaus Fortschegger , Regina Grillari
IPC: C07C229/52 , C07D231/14 , C07C65/24 , C07D231/18
CPC classification number: C07C229/52 , C07C65/24 , C07C69/78 , C07C69/94 , C07D231/14 , C07D231/18 , C12Q1/44
Abstract: The invention provides a compound of formula (I) as defined herein that is useful in the treatment and prevention of a disorder such as cachexia, stroke, atherosclerosis, coronary artery disease, or diabetes and disorders and conditions associated therewith. The invention also provides a method of screening for lipase inhibitors using a compound of formula (I) and determining its lipase inhibitory activity. activity.
Abstract translation: 本发明提供了本文定义的式（I）化合物，其可用于治疗和预防诸如恶病质，中风，动脉粥样硬化，冠状动脉疾病或糖尿病以及与之相关的疾病和病症的病症。 本发明还提供使用式（I）化合物筛选脂肪酶抑制剂并测定其脂肪酶抑制活性的方法。 活动。
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公开(公告)号：US09926532B2
公开(公告)日：2018-03-27
申请号：US13997976
申请日：2011-12-23
Applicant: Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
Inventor： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
IPC: C12N5/00 , C12N5/02 , C12N5/074 , C12N5/0789
CPC classification number: C12N5/0696 , C12N5/0647
Abstract: Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.
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5.发明申请公开(公告)号：US20130323782A1
公开(公告)日：2013-12-05
申请号：US13997976
申请日：2011-12-23
Applicant: Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
Inventor： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
IPC: C12N5/074
CPC classification number: C12N5/0696 , C12N5/0647
Abstract: Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.
Abstract translation: 通过重新编程以非侵入性方式获得的供体细胞产生iPSC和分化细胞的方法。 特别地，供体细胞是脱落的上皮细胞。 分化的细胞可以通过重新编程的iPSC的分化或通过直接重新编程尿细胞获得。
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6.发明申请公开(公告)号：US20130108687A1
公开(公告)日：2013-05-02
申请号：US13699272
申请日：2011-05-23
Applicant: Johannes Grillari , Elisabeth Schraml , Klaus Fortschegger , Regina Grillari
Inventor： Johannes Grillari , Elisabeth Schraml , Klaus Fortschegger , Regina Grillari
IPC: A61K31/7105 , A61K9/127 , C12N15/113
CPC classification number: C12N15/113 , A61K9/127 , A61K31/7105 , C12N15/1138 , C12N2310/113 , C12N2310/141 , C12Q1/6881
Abstract: Compositions of an inhibitor of a polynucleotide for use in treating or preventing bone disorders such as osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against miR-31 and derivatives thereof. Also, methods for diagnosing and compositions for use in diagnosing bone disorders. Compounds to be employed in these diagnostic methods and uses include compounds such as miR-31.
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公开(公告)号：US07202352B2
公开(公告)日：2007-04-10
申请号：US10181059
申请日：2001-01-22
Applicant: Hermann Katinger , Johannes Grillari , Reingard Grabherr
Inventor： Hermann Katinger , Johannes Grillari , Reingard Grabherr
CPC classification number: C07K14/4747
Abstract: The present invention relates to cell-regulatory proteins and to nucleotide sequences encoding said proteins wherein the proteins have been found to be potential tumor and/or senescense markers useful for medical diagnostics and additionally having therapeutical potential as well as antiapoptotic properties useful for improving cell viability in cell culture technology. The invention further relates to antibodies directed against the cell-regulatory proteins and to their use in medical diagnostics and therapy. The invention further relates to methods for the manufacture and application of the cell-regulatory proteins and of the corresponding nucleotide sequences.
Abstract translation: 本发明涉及细胞调节蛋白和编码所述蛋白质的核苷酸序列，其中所述蛋白质已经被发现是潜在的肿瘤和/或用于医学诊断的并且具有治疗潜力的抗衰老标记物，以及可用于改善细胞活力的抗细胞凋亡性质 在细胞培养技术中。 本发明还涉及针对细胞调节蛋白的抗体及其在医学诊断和治疗中的应用。 本发明还涉及制造方法
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