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公开(公告)号：US08390817B2
公开(公告)日：2013-03-05
申请号：US12810867
申请日：2008-12-18
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
CPC分类号： G01N21/552
摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.
摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。
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公开(公告)号：US20120040475A1
公开(公告)日：2012-02-16
申请号：US13201927
申请日：2010-02-08
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).
摘要翻译： 本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。 感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。 感测装置（100）还包括位于参考区域（120）处的参考元件（121）。 参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响 （2）。 这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。 反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。
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公开(公告)号：US09804089B2
公开(公告)日：2017-10-31
申请号：US13201927
申请日：2010-02-08
IPC分类号： G01N21/552 , G01N33/543 , G01N21/27
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).
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公开(公告)号：US09658219B2
公开(公告)日：2017-05-23
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N33/543 , G01N27/74 , G01N21/39
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.
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公开(公告)号：US08228506B2
公开(公告)日：2012-07-24
申请号：US12670148
申请日：2008-07-17
CPC分类号： G01N21/552 , G01N21/648 , G01N27/745 , G01N2201/064 , G01N2201/0691 , G01N2201/0696
摘要： A microelectronic sensor device and a method for making optical examinations at a carrier for the detection of magnetic particles, for example, at a contact surface of the carrier by frustrated total internal reflection (FTIR), include a light source with a laser modulator for emitting an input light beam into the carrier. The input light beam is modulated such that optical interferences with reflections of the input light beam from the entrance window, or from other components of the carrier, are reduced or minimized. This can be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are induced by thermal extension, for example.
摘要翻译： 微电子传感器装置和用于在载体处用于检测磁性颗粒的光学检查的方法，例如通过沮丧的全内反射（FTIR）在载体的接触表面处，包括具有用于发射的激光调制器的光源 输入光束进入载体。 输入光束被调制成使得来自入口窗口的输入光束或者来自载体的其它部件的反射的光学干涉被减小或最小化。 这可以通过脉冲开/关调制来实现，其中当前发射的脉冲（PN）的第一弛豫最小值在光源中与反射脉冲（PN-1'）的第一弛豫最大值重合。 通过减少干扰的影响，例如，该设置不容易受到由热延伸引起的尺寸变化的干扰。
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公开(公告)号：US20100290052A1
公开(公告)日：2010-11-18
申请号：US12810867
申请日：2008-12-18
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Henricus Maria Kahlman
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G01N21/55
CPC分类号： G01N21/552
摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.
摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。
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公开(公告)号：US08670123B2
公开(公告)日：2014-03-11
申请号：US13379721
申请日：2010-06-21
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译： 本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。 为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到 一个共同的平面（P）。 由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。
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公开(公告)号：US08520211B2
公开(公告)日：2013-08-27
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.
摘要翻译： 用于样品室中的样品的光学检测的载体和设备包括用于将输入光束折射到相邻样品室中的光学结构，并且用于从输入光束收集来自样品室的光的输出光束 。 光学结构包括在载体的表面中的凹槽，其中输入光束在短距离内透射通过样品。 光学结构也可用于润湿检测。
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公开(公告)号：US08486689B2
公开(公告)日：2013-07-16
申请号：US12747529
申请日：2008-10-31
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
IPC分类号： C12M1/00
CPC分类号： G01N21/1717 , G01N21/552 , G01N21/648 , G01N2021/1721 , G01N2021/1727 , G01N2201/0691
摘要： The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (L1) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.
摘要翻译： 本发明涉及一种用于检查在载体（11）的结合表面（12）处结合到结合位点（3）的靶颗粒（1）的微电子传感器装置。 在优选实施例中，输入光束（L1）被传输到载体（11）中，其中在结合表面（12）处发生挫败的全内反射（FTIR）。 通过光检测器（31）检测所得到的输出光束（L2）中的光量，并提供关于在结合表面处存在目标颗粒的信息。 此外，致动单元（50）通过与磁场（B）或电场的相互作用（特别是给定的调制频率（COIn））的相互作用来诱导结合的目标颗粒（1）的运动，使得通过解调 目标颗粒的检测器信号（S）效应可以与背景区分开。
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公开(公告)号：US20120147377A1
公开(公告)日：2012-06-14
申请号：US13379721
申请日：2010-06-21
CPC分类号： G02B3/0068 , G01N21/552 , G01N21/648 , G01N2201/0638 , G02B27/1066 , G02B27/126
摘要： The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.
摘要翻译： 本发明涉及用于生物传感器（10）的聚焦光学器件（100），其允许以简单的方式将扩展的检测区域（13）精确地成像到检测器平面（P）上。 为此，聚焦光学器件（100）包括彼此相邻布置的至少两个聚焦小透镜（LL），使得它们将沿着主光轴（MOA）定向的入射平行光束（L2）成像到 一个共同的平面（P）。 由聚焦光学器件（100）接收的输出光束（L2）可以优选地源于透明载体的调查区域（13）处的平行输入光束（L1）的全内反射。
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