公开(公告)号：US20240085332A1

公开(公告)日：2024-03-14

申请号：US18467469

申请日：2023-09-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： William Benman ,  Lukasz Bugaj ,  Brian Chow ,  Saachi Datta ,  David Gonzalez-Martinez ,  Jose Avalos

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N2201/0446 ,  G01N2201/0627 ,  G01N2201/064

Abstract: Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

公开(公告)号：US11770596B2

公开(公告)日：2023-09-26

申请号：US16893814

申请日：2020-06-05

Applicant: CANON KABUSHIKI KAISHA

Inventor： Takeaki Itsuji ,  Noriyuki Kaifu

IPC: G01N21/3581 ,  H04N23/52 ,  H04N23/51 ,  H04N23/54

CPC classification number: H04N23/52 ,  G01N21/3581 ,  H04N23/51 ,  H04N23/54 ,  G01N2201/064

Abstract: A terahertz wave camera that acquires information on a measurement target includes: a sensor unit in which a plurality of elements having spectral sensitivity to the terahertz wave are arranged; a readout circuit unit that reads out signals from the elements; a first light-shielding portion; and an optical unit. The first light-shielding portion reduces disturbance light to which the readout circuit unit has spectral sensitivity. The optical unit guides a terahertz wave from the measurement target to the sensor unit.

公开(公告)号：US20180206739A1

公开(公告)日：2018-07-26

申请号：US15743937

申请日：2016-07-13

Applicant: Singapore University of Technology and Design ,  Changi General Hospital Pte Ltd

Inventor： Juan Pablo Forero Cortes ,  Suranga Chandima Nanayakkara ,  Shaohul Foong ,  Chang Yin Chionh

IPC: A61B5/02 ,  G01N21/31 ,  A61M1/36 ,  G01N21/3554

CPC classification number: A61B5/02042 ,  A61B5/00 ,  A61B2562/0214 ,  A61B2562/029 ,  A61M1/3656 ,  A61M2205/15 ,  A61M2205/3306 ,  G01N21/3151 ,  G01N21/3554 ,  G01N2021/3155 ,  G01N2021/3181 ,  G01N2201/064

Abstract: An on-site device for detecting presence of a liquid from a site and a method for detecting presence of a liquid from a site using the on-site device, the device comprising a moisture detector arranged to detect the presence of the liquid based on one or more electrical characteristics of the liquid; a first optical detector assembly coupled to the moisture detector, the first optical detector assembly being configured to be activated upon detection of the presence of the liquid by the moisture detector; and wherein upon activation, the first optical detector assembly is configured to detect a substance in the liquid based on one or more optical characteristics of the substance.

公开(公告)号：US20170262694A1

公开(公告)日：2017-09-14

申请号：US15456240

申请日：2017-03-10

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Audrey K. Bowden ,  Nicholas Dwork ,  Mehdi Javanmard ,  Saara Anwar Khan ,  Kiran Rana Magar ,  Matthew Alexander Millet ,  Gennifer Tanabe Smith

IPC: G06K9/00 ,  G06K9/20 ,  G06T7/90 ,  G06T7/80 ,  G01N33/18 ,  G01N21/25 ,  G01N21/27 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G02B21/36 ,  G06T7/73

CPC classification number: G01N33/18 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0267 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/50 ,  G01J3/52 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N2021/7759 ,  G01N2201/064 ,  G02B21/008 ,  G02B21/34 ,  G02B21/365 ,  G06K9/00127

Abstract: Improved colorimetric analysis of liquid samples is provided. A sample holder is used that delivers predetermined volumes of sample individually to each of several colorimetric test patches at the same time with a sliding action. An opaque housing is employed to prevent ambient light from reaching the test patches when color images of the test patches are acquired. Preferably, a mobile electronic device including a camera is attached to the opaque housing to acquire the images. Optical microscopy can be performed in addition to the colorimetric analysis.

公开(公告)号：US20170248574A1

公开(公告)日：2017-08-31

申请号：US15594978

申请日：2017-05-15

Applicant: CELLOMICS, INC.

Inventor： Richik Niloy Ghosh ,  Dirk John VandenBerg, III ,  Keith Rao Heffley ,  Monica Jo Tomaszewski ,  Jeffrey Robert Haskins

IPC: G01N33/487 ,  G01N21/31 ,  G02B5/02 ,  G02B21/16 ,  G02B21/36 ,  G01N21/64 ,  G01N35/00

CPC classification number: G01N33/487 ,  F21Y2105/10 ,  F21Y2105/14 ,  G01N21/253 ,  G01N21/255 ,  G01N21/31 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N35/00029 ,  G01N2021/6439 ,  G01N2021/6491 ,  G01N2035/00158 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/064 ,  G02B5/0278 ,  G02B5/0294 ,  G02B21/16 ,  G02B21/367

Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.

公开(公告)号：US09726604B2

公开(公告)日：2017-08-08

申请号：US14924815

申请日：2015-10-28

Applicant: Hiroyoshi Sekiguchi ,  Shintaroh Kida ,  Kohji Oshikiri ,  Izumi Itoh

Inventor： Hiroyoshi Sekiguchi ,  Shintaroh Kida ,  Kohji Oshikiri ,  Izumi Itoh

IPC: G01N21/55 ,  B60Q1/08 ,  B60S1/08 ,  B60R16/023 ,  G01N21/552 ,  G01N21/94 ,  G01N21/958

CPC classification number: G01N21/55 ,  B60Q1/085 ,  B60R16/023 ,  B60S1/0844 ,  G01N21/552 ,  G01N21/94 ,  G01N2021/945 ,  G01N2021/9586 ,  G01N2201/061 ,  G01N2201/063 ,  G01N2201/064

Abstract: An adhering detection apparatus includes a light source to emit probe light to a light translucent object during an emission period, and to stop an emission of the probe light to the light translucent object during a non-emission period, a light receiver to receive light coming from the light translucent object during the emission period and the non-emission period of the light source, and an adhering detection processor to perform an adhering detection processing for detecting a substance adhering to the light translucent object based on light quantity of the light coming from the light translucent object and received by the light receiver, and to output a detection result of the adhering detection processing. The adhering detection processor selectively performs one or more processes depending on the light quantity of the light received by the light receiver during the non-emission period of the light source.

公开(公告)号：US09638624B2

公开(公告)日：2017-05-02

申请号：US14434171

申请日：2013-10-07

Applicant: EMPA EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT

Inventor： Markus Mangold ,  Bela Tuzson ,  Lukas Emmenegger

IPC: G01N21/03 ,  G01N21/3504

CPC classification number: G01N21/031 ,  G01N21/3504 ,  G01N2201/064

Abstract: A Multi-pass optical cell (1) with an internal space (11) for laser spectroscopy is described, which is able to reduce or eliminate interference fringes appearing by performing laser absorption spectroscopy in the multi-pass optical cells (1) leading to improved absorption spectra. This is achieved by using a multi-pass optical cell (1) comprising an absorption mask (3) which is permanently or removable mountable in the internal space (11) in a rotatably fixed manner, where in a mask wall (30) a plurality of m apertures (300) is formed, in which the position of each aperture (300) is adapted to a predefinable propagation path of a main optical beam and/or the resulting reflection spot pattern (211) defined by the geometry of the multi-pass optical cell (1) and the used angle of incidence of an initial beam (20), so that each aperture (300) is traversable by the main optical beam from a first side (301) to a second side (302).

公开(公告)号：US20170115209A1

公开(公告)日：2017-04-27

申请号：US15292414

申请日：2016-10-13

Applicant: Nix Sensor Ltd.

Inventor： Matthew Sheridan

IPC: G01N21/25 ,  G01N21/01 ,  G01N33/08

CPC classification number: G01N21/251 ,  G01J3/50 ,  G01J3/501 ,  G01N21/01 ,  G01N21/03 ,  G01N21/255 ,  G01N33/08 ,  G01N2021/4757 ,  G01N2021/4769 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/064 ,  G01N2201/08

Abstract: The present concept is a method of preparing an egg to determine the color of the egg using an egg yolk cover. The egg yolk cover is dome-shaped with a base edge and inspection area. The egg yolk cover eliminates ambient light from impinging on the egg yolk and is used in combination with a light sensor to determine the color of egg yolks. The light sensor includes a single flat printed circuit board with a top and bottom side which includes at least one LED light and one color sensor, at least one light pipe receiving light from the LED and transmitting it onto a substrate at an angle theta and a tube frame including an optical tube for receiving light reflections from the substrate. The light pipes and the tube frame are compression fit between the printed circuit board and a lower housing. To determine the color of the egg yolk, the egg is first cracked onto a flat surface. The egg yolk cover is then placed over the egg yolk and the color sensor is placed onto the inspection area to measure the color.

公开(公告)号：US09506870B2

公开(公告)日：2016-11-29

申请号：US13926679

申请日：2013-06-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Makoto Ogusu

IPC: G01N21/75 ,  G01N21/05 ,  B01L3/00 ,  G01N21/00

CPC classification number: G01N21/75 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N21/05 ,  G01N2021/056 ,  G01N2201/064 ,  Y10T436/143333

Abstract: The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove.

Abstract translation: 本发明提供了一种用于检测发光的流路装置，其抑制源自不必要的发光的噪声，并且可以使用有机材料简单地结合。 具有流动通道的流动通道装置通过至少两个基板的结合而构成，其中至少一个基板具有构成流动通道的第一凹槽，以及用于在其中布置粘合剂的第二凹槽，其中包含有机材料 并且在所述第二槽的内壁上设置有遮光层，以阻挡从所述第二凹槽发射的光穿透到所述第一凹槽中。

公开(公告)号：US20160266044A1

公开(公告)日：2016-09-15

申请号：US15031866

申请日：2014-10-15

Applicant: TecSense Gmbh

Inventor： Volker RIBITSCH ,  Johannes KROTTMAIER

IPC: G01N21/77

CPC classification number: G01N21/77 ,  G01J3/0202 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/645 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2021/7796 ,  G01N2201/064

Abstract: An optochemical sensor comprises a measuring element excitable by the light of an excitation light source and in contact with a medium to be measured, and a measuring arrangement including at least one excitation light source and a detector as well as a hood separating the measuring arrangement from the measuring element, wherein the excitation light source and the detector are fixed to a base plate arranged in parallel with the measuring element, the hood, the excitation light source and the detector are separated from one another by at least a portion of the material thickness of the hood, and light from the excitation light source through an optical waveguide impinges on the measuring element at such an angle that fluorescence light emitted by the measuring element impinges perpendicularly on the detector.

Abstract translation: 光化学传感器包括由激发光源的光可激发并与待测介质接触的测量元件，以及包括至少一个激发光源和检测器的测量装置以及将测量装置与 所述测量元件，其中所述激发光源和所述检测器固定到与所述测量元件平行设置的基板，所述罩，所述激发光源和所述检测器通过所述材料厚度的至少一部分彼此分离 并且来自激发光源的通过光波导的光以这样的角度照射在测量元件上，使得由测量元件发射的荧光垂直照射在检测器上。