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    Methods of identifying analytes and using encoded particles
    1.
    发明授权
    Methods of identifying analytes and using encoded particles 有权
    识别分析物和使用编码的粒子的方法

    公开(公告)号：US08049893B2

    公开(公告)日：2011-11-01

    申请号：US12941568

    申请日：2010-11-08

    申请人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G01N21/25

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method of identifying analytes that react with probes on encoded particles. The method includes providing a support substrate that has a plurality of the particles randomly distributed on the support substrate. The particles have elongated bodies with codes that extend along the corresponding bodies. The codes identify probes that are attached to the corresponding bodies, wherein at least some of the probes include fluorescent labels from reactions with the analytes. The method also includes detecting fluorescent signals that are emitted from the fluorescent labels. The fluorescent signals emit from random spatial locations along the support substrate. The method also includes detecting the codes of the particles at the random spatial locations along the support substrate and analyzing the codes and the fluorescent signals to identify the analytes that react with the probes on the particles.

    摘要翻译： 识别与编码粒子上的探针反应的分析物的方法。 该方法包括提供具有随机分布在支撑衬底上的多个颗粒的支撑衬底。 颗粒具有细长体，其具有沿相应体部延伸的代码。 代码识别附着于相应体的探针，其中至少一些探针包括与分析物反应的荧光标记。 该方法还包括检测从荧光标记物发射的荧光信号。 荧光信号沿着支撑衬底从随机空间位置发射。 该方法还包括沿着支撑衬底的随机空间位置检测颗粒的代码并分析代码和荧光信号以识别与颗粒上的探针反应的分析物。

    Optical reader system for substrates having an optically readable code
    2.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US08333325B2

    公开(公告)日：2012-12-18

    申请号：US13014298

    申请日：2011-01-26

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译： 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

    Optical reader system for substrates having an optically readable code
    3.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US07900836B2

    公开(公告)日：2011-03-08

    申请号：US12174490

    申请日：2008-07-16

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

    Methods of identifying an analyte and nucleic acid analysis
    4.
    发明授权
    Methods of identifying an analyte and nucleic acid analysis 有权
    识别分析物和核酸分析的方法

    公开(公告)号：US07843567B2

    公开(公告)日：2010-11-30

    申请号：US12644255

    申请日：2009-12-22

    申请人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G01N21/25

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

    摘要翻译： 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

    Optical reader for diffraction grating-based encoded optical identification elements
    6.
    发明授权
    Optical reader for diffraction grating-based encoded optical identification elements 有权
    用于衍射光栅编码光学识别元件的光学读取器

    公开(公告)号：US07441703B2

    公开(公告)日：2008-10-28

    申请号：US10956791

    申请日：2004-10-01

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  B01J2219/005 ,  B01J2219/0056 ,  G06K7/1094 ,  G06K19/06009 ,  G06K2019/06225 ,  G06K2019/06234 ,  G06K2019/0629 ,  G07D7/0032 ,  G07D7/004

    摘要： An optical reader system 7 for diffraction grating-based encoded microbeads (or bead reader system), comprises a reader box 100, which accepts a bead cell (or cuvette) 102 that holds the microbeads 8, having an embedded code therein. The reader box 100 interfaces along lines 103 with a known computer system 104. The reader box 100 interfaces with a stage position controller 112 and the controller 112 interfaces along a line 115 with the computer system 104 and a manual control device (or joy stick) 116 along a line 117. The reader interrogates the microbeads to determine the embedded code and/or the fluorescence level on the beads. The reader provides information similar to a bead flow cytometer but in a planar format, i.e., a virtual cytometer.

    摘要翻译： 用于基于衍射光栅的编码微珠（或珠读取器系统）的光学读取器系统7包括读取器盒100，其接收保持微珠8的珠细胞（或比色杯）102，其中具有嵌入代码。 读取器箱100沿着线103与已知的计算机系统104相接口。读取箱100与平台位置控制器112连接，并且控制器112沿着线115与计算机系统104和手动控制装置（或操纵杆） 读取器询问微珠以确定珠上的嵌入代码和/或荧光水平。 读者提供类似于珠流式细胞仪的信息，但是以平面格式，即虚拟血细胞计数器。

    Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
    7.
    发明授权
    Method and apparatus for labeling using diffraction grating-based encoded optical identification elements 有权
    使用基于衍射光栅的编码光学识别元件进行标记的方法和设备

    公开(公告)号：US07126755B2

    公开(公告)日：2006-10-24

    申请号：US10661082

    申请日：2003-09-12

    申请人： John A. Moon ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li ,  James Dunphy ,  F. Kevin Didden

    发明人： John A. Moon ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li ,  James Dunphy ,  F. Kevin Didden

    IPC分类号： G02B5/18

    CPC分类号： G03H1/0272 ,  B01J2219/00459 ,  B01J2219/00463 ,  B01J2219/0047 ,  B01J2219/005 ,  B01J2219/00547 ,  B01J2219/00576 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0636 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0487 ,  G03H2210/53 ,  G03H2230/10 ,  G03H2270/20 ,  G03H2270/24

    摘要： A method and apparatus for labeling an item using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The encoded element 8 may be used to label any desired item, such as large or small objects, products, solids, powders, liquids, gases, plants, minerals, cells and/or animals, or any combination of or portion of one or more thereof. The label may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products.

    摘要翻译： 使用基于衍射光栅的编码光学识别元件8来标记物品的方法和设备包括具有设置在其中的至少一个衍射光栅12的光学基板10。 光栅12具有一个或多个共同定位的间距Lambda，其表示当被入射光24照射时检测到的唯一识别数字码。 入射光24可以从具有窄带（单波长）或多个波长源的基板10的一侧（或从一端）横向引导，并且代码由光或波长光谱的空间分布表示， 或其组合。 元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。 编码元件8可以用于标记任何期望的物品，例如大的或小的物体，产品，固体，粉末，液体，气体，植物，矿物，细胞和/或动物，或者一个或多个的任何组合或部分 其中。 该标签可用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。 在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。

    Hybrid random bead/chip based microarray
    9.
    发明授权
    Hybrid random bead/chip based microarray 有权
    混合随机珠/芯片基微阵列

    公开(公告)号：US07164533B2

    公开(公告)日：2007-01-16

    申请号：US10763995

    申请日：2004-01-22

    申请人： John Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G02B5/18

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method and apparatus f or performing an assay process, featuring providing microbeads in a solution; placing the microbeads on an alignment substrate; reading codes of the microbeads and the position thereof on the alignment substrate; reading the fluorescence on each microbead and the position order thereof on the alignment substrate; and determining an assay result based on bead position order and bead code of the earlier reading steps, where the microbead is an encoded particle having a particle substrate; a portion of the substrate being made of a substantially single material and having at least one diffraction grating embedded therein, the grating having a resultant refractive index variation within the single material at a grating location; and the grating providing an optical output signal indicative of a code when illuminated by an incident light signal propagating from outside said substrate, the optical output signal being a result of passive, non-resonant scattering from said grating when illuminated by said incident light signal.

    摘要翻译： f或执行测定过程的方法和装置，其特征在于在溶液中提供微珠; 将微珠放置在取向基板上; 读取微珠的代码及其位置; 读取每个微珠上的荧光及其在取向基板上的位置顺序; 并且基于早期阅读步骤的珠粒位置顺序和珠粒码确定测定结果，其中微珠是具有颗粒底物的编码颗粒; 衬底的一部分由基本上单一的材料制成并且具有嵌入其中的至少一个衍射光栅，所述光栅在光栅位置处具有单个材料内的折射率变化; 并且所述光栅提供指示当通过从所述衬底外部传播的入射光信号照射时的代码的光学输出信号，所述光学输出信号是当被所述入射光信号照亮时来自所述光栅的被动的非共振散射的结果。

    Diffraction grating-based encoded microparticle assay stick
    10.
    发明授权
    Diffraction grating-based encoded microparticle assay stick 有权
    基于衍射光栅的编码微粒测定棒

    公开(公告)号：US07901630B2

    公开(公告)日：2011-03-08

    申请号：US11226914

    申请日：2005-09-13

    申请人： Martin A. Putnam ,  John A. Moon ,  Tuo Li

    发明人： Martin A. Putnam ,  John A. Moon ,  Tuo Li

    IPC分类号： G01N33/00 ,  G01N33/556 ,  G03H1/00 ,  C12M1/34 ,  C12M3/00

    CPC分类号： G01N21/4788 ,  G01N21/6428 ,  G03H1/26 ,  G03H2001/0033

    摘要： An assay stick 7 includes a transparent reaction vessel or tube 14 having one or more microbeads 8 disposed therein. The microbeads 8 have a plurality of unique identification digital codes based on a diffraction grating 12 disposed therein that are detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the tube 14 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The assay stick 7 may be reused or disposed upon completion of the assay. Alternatively, the beads may be attached to a strip or planar surface. The encoded beads can also provide traceability, quality-control, and authenticity of each bead 8 to its source and/or to the chemistry on each bead 8. Also, the low sample volume of the assay stick allows for faster reactions and better sensitivity.

    摘要翻译： 测定棒7包括其中设置有一个或多个微珠8的透明反应容器或管14。 微珠8具有基于设置在其中的衍射光栅12的多个独特的识别数字代码，其被入射光24照射时检测。入射光24可以横向地被引导到管14的一侧或一端上，其中 窄带（单波长）或多波长源，在这种情况下，码分别由光或波长光谱的空间分布表示。 测定棒7可以在测定完成后重复使用或放置。 或者，珠可以附接到条或平面表面。 编码的珠粒还可以提供每个珠粒8到其来源和/或每个珠粒8上的化学物质的可追溯性，质量控制和真实性。而且，测定棒的低样本体积允许更快的反应和更好的灵敏度。