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    Method and apparatus for performing assays
    2.
    发明授权
    Method and apparatus for performing assays 有权
    用于进行测定的方法和装置

    公开(公告)号：US09229001B2

    公开(公告)日：2016-01-05

    申请号：US13511593

    申请日：2010-11-23

    申请人： Martin A. Putnam ,  Alan D. Kersey

    发明人： Martin A. Putnam ,  Alan D. Kersey

    IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N35/10

    CPC分类号： G01N33/54366 ,  B01L3/502715 ,  B01L3/502784 ,  B01L3/527 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2400/0633 ,  G01N35/1097

    摘要： An apparatus is provided for performing an chemical, biochemical, or biological assay on a sample comprising: a microfluidic assay cartridge (1) that contains at least one sample inlet well (2) configured to receive a sample; and a microfluidic sub-unit (3) associated with the microfluidic assay cartridge (1) and comprising microfluidic channels (8), micro-valves (4, 4a, 9) and at least one separate and fluidicly-isolated isolation channel (5), and at least one hollow element (14); the at least one hollow element (14) being functionalized with a capture moiety or molecules (15) so as to form at least one reaction vessel (19); the microfluidic channels (8) and micro-valves (4, 4a, 9) configured to respond to signaling containing information about performing the assay and to controllably receive the sample and at least one reagent in the at least one reaction vessel (19), and to provide from the at least one reaction vessel (19) light containing information about the assay performed on the sample inside the at least one reaction vessel (19) as a result of said at least one reagent.

    摘要翻译： 提供了一种用于对样品进行化学，生化或生物测定的装置，包括：微流体测定盒（1），其包含至少一个被配置为接收样品的样品入口孔（2） 和与微流体测定盒（1）相关联并且包括微流体通道（8），微阀（4,4a，9）和至少一个单独和流体隔离的隔离通道（5）的微流体子单元（3） ，和至少一个中空元件（14）; 所述至少一个中空元件（14）被捕获部分或分子（15）功能化，以形成至少一个反应容器（19）; 微流体通道（8）和微阀（4,4a，9）被配置为对包含关于进行测定的信息的信号进行响应并且可控制地接收样品和至少一个反应容器（19）中的至少一个试剂， 并且从所述至少一个反应容器（19）提供含有关于由所述至少一种试剂的结果对所述至少一个反应容器（19）内的样品进行的测定的信息的光。

    Acoustic Standing Wave Particle Size or Distribution Detection
    3.
    发明申请
    Acoustic Standing Wave Particle Size or Distribution Detection 审中-公开
    声波波粒度或分布检测

    公开(公告)号：US20140318225A1

    公开(公告)日：2014-10-30

    申请号：US14005581

    申请日：2012-03-19

    申请人： Alan D. Kersey

    发明人： Alan D. Kersey

    IPC分类号： G01N15/02

    CPC分类号： G01N15/0255 ,  G01N2015/0053

    摘要： Apparatus features an acoustic comb filter module configured to receive signaling containing information about different frequencies F1 and F2 to create a selected comb spacing D to capture certain particles having a selected size X in a flow stream in a flow pipe, and to provide an acoustic standing wave via ultrasonic excitation based at least partly on the two different frequencies F1 and F2 to create the selected comb spacing D to capture the certain particles having the selected size X in the flow stream in the flow pipe. The apparatus may also include a particle size or distribution determination module configured to receive the certain particles for off-stream analysis via a detection port that forms part of the flow pipe and determine the particle size or distribution of the certain particles in the flow stream in the flow pipe.

    摘要翻译： 声学梳状滤波器模块被配置为接收包含关于不同频率F1和F2的信息的信号，以产生所选择的梳齿间隔D以在流管中的流动流中捕获具有选定尺寸X的某些粒子，并且提供声场 通过至少部分地基于两个不同频率F1和F2的超声波激发波形，以产生所选择的梳齿间隔D，以在流管中的流动流中捕获具有选定尺寸X的某些粒子。 该装置还可以包括粒度或分布确定模块，其被配置为经由形成流管的一部分的检测端口接收用于离线分析的某些颗粒，并且确定流动流中某些颗粒的粒度或分布 流管。

    Side-hole cane waveguide sensor
    6.
    发明授权
    Side-hole cane waveguide sensor 有权
    侧孔拐杖波导传感器

    公开(公告)号：US08494322B2

    公开(公告)日：2013-07-23

    申请号：US12716035

    申请日：2010-03-02

    申请人： Alan D. Kersey ,  John L. Maida

    发明人： Alan D. Kersey ,  John L. Maida

    IPC分类号： G02B6/26

    CPC分类号： G02B6/02314 ,  E21B47/123 ,  G01L1/242 ,  G01L1/245 ,  G01L1/246 ,  G01L11/025 ,  G02B6/021 ,  G02B6/022 ,  G02B6/02338 ,  G02B6/024 ,  G02B6/028 ,  G02B6/0281 ,  G02B6/262

    摘要： A side-hole optical cane for measuring pressure and/or temperature is disclosed. The side-hole cane has a light guiding core containing a sensor and a cladding containing symmetrical side-holes extending substantially parallel to the core. The side-holes cause an asymmetric stress across the core of the sensor creating a birefringent sensor. The sensor, preferably a Bragg grating, reflects a first and second wavelength each associated with orthogonal polarization vectors, wherein the degree of separation between the two is proportional to the pressure exerted on the core. The side-hole cane structure self-compensates and is insensitive to temperature variations when used as a pressure sensor, because temperature induces an equal shift in both the first and second wavelengths. Furthermore, the magnitude of these shifts can be monitored to deduce temperature, hence providing the side-hole cane additional temperature sensing capability that is unaffected by pressure. Additionally, the side-hole cane can be used to measure a differential pressure between a first pressure ported to the side-holes and a second external pressure.

    摘要翻译： 公开了用于测量压力和/或温度的侧孔光学手杖。 侧孔拐杖具有包含传感器和包含基本上平行于芯延伸的对称侧壁的包层的导光芯。 侧孔在传感器的核心上产生不对称应力，产生双折射传感器。 传感器，优选布拉格光栅，反射与正交偏振矢量相关联的第一和第二波长，其中两者之间的分离度与施加在芯上的压力成比例。 当用作压力传感器时，侧孔手杖结构自我补偿并且对温度变化不敏感，因为温度在第一和第二波长两者中都产生相等的移动。 此外，可以监测这些位移的大小以推断温度，从而提供不受压力影响的侧孔拐角附加温度检测能力。 此外，侧孔手杖可用于测量端口与侧孔的第一压力和第二外部压力之间的差压。

    Optical reader system for substrates having an optically readable code
    7.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US08333325B2

    公开(公告)日：2012-12-18

    申请号：US13014298

    申请日：2011-01-26

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译： 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

    LARGE DIAMETER OPTICAL WAVEGUIDE, GRATING AND LASER
    8.
    发明申请
    LARGE DIAMETER OPTICAL WAVEGUIDE, GRATING AND LASER 有权
    大直径光波导，光栅和激光

    公开(公告)号：US20120082175A1

    公开(公告)日：2012-04-05

    申请号：US13316069

    申请日：2011-12-09

    申请人： Martin A. Putnam ,  Robert N. Brucato ,  Paul E. Sanders ,  Timothy J. Bailey ,  James M. Sullivan ,  Alan D. Kersey

    发明人： Martin A. Putnam ,  Robert N. Brucato ,  Paul E. Sanders ,  Timothy J. Bailey ,  James M. Sullivan ,  Alan D. Kersey

    IPC分类号： H01S3/30 ,  G02B6/036 ,  H01S3/08 ,  G02B6/02

    CPC分类号： G02B6/022 ,  G02B6/02 ,  G02B6/02042 ,  H01S3/06708 ,  H01S3/06729 ,  H01S3/06754

    摘要： A large diameter optical waveguide, grating, and laser includes a waveguide having at least one core surrounded by a cladding, the core propagating light in substantially a few transverse spatial modes; and having an outer waveguide dimension of said waveguide being greater than about 0.3 mm. At least one Bragg grating may be impressed in the waveguide. The waveguide may be axially compressed which causes the length of the waveguide to decrease without buckling. The waveguide may be used for any application where a waveguide needs to be compression tuned. Also, the waveguide exhibits lower mode coupling from the core to the cladding and allows for higher optical power to be used when writing gratings without damaging the waveguide. The waveguide may resemble a short “block” or a longer “cane” type, depending on the application and dimensions used.

    摘要翻译： 大直径光波导，光栅和激光器包括具有由包层围绕的至少一个核的波导，所述核以基本上几个横向空间模式传播光; 并且具有所述波导的外波导尺寸大于约0.3mm。 至少一个布拉格光栅可以印在波导中。 波导可以被轴向压缩，这导致波导的长度减小而没有弯曲。 波导可以用于波导需要被压缩调谐的任何应用。 此外，波导表现出从芯到包层的较低模式耦合，并且允许在写入光栅时使用更高的光功率而不损坏波导。 根据使用的应用和尺寸，波导可能类似于短的“块”或更长的“手杖”类型。

    Optical reader system for substrates having an optically readable code
    10.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US07900836B2

    公开(公告)日：2011-03-08

    申请号：US12174490

    申请日：2008-07-16

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。