公开(公告)号：US20050277685A1

公开(公告)日：2005-12-15

申请号：US10524697

申请日：2003-08-27

申请人： John Acton III ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

发明人： John Acton III ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

IPC分类号： C07D209/12 ,  A61K31/404 ,  A61K31/405 ,  A61K31/42 ,  A61P3/10 ,  C07D209/10 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/02 ,  C07D413/04 ,  C07D43/02

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：US20070161689A1

公开(公告)日：2007-07-12

申请号：US11714341

申请日：2007-03-06

申请人： John Acton ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

发明人： John Acton ,  Sheryl Debenham ,  Kun Liu ,  Peter Meinke ,  Harold Wood ,  Regina Black

IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/416 ,  A61K31/405 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：US20050272788A1

公开(公告)日：2005-12-08

申请号：US10525470

申请日：2003-08-28

申请人： John Acton ,  Peter Meinke ,  Harold Wood ,  Regina Black

发明人： John Acton ,  Peter Meinke ,  Harold Wood ,  Regina Black

IPC分类号： A61K31/403 ,  A61K31/415 ,  C07D209/36 ,  C07D413/04 ,  C07D413/14 ,  C07D43/02

CPC分类号： C07D413/14 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

摘要翻译： 具有芳氧基链烷酸取代基或芳基链烷酸取代基的吲哚是PPARγ的激动剂或部分激动剂，并且可用于治疗和控制II型糖尿病症状的高血糖，以及血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症和肥胖症 经常与2型糖尿病相关。

公开(公告)号：US20050256117A1

公开(公告)日：2005-11-17

申请号：US10511636

申请日：2003-06-11

申请人： Meng Hsin Chen ,  Luping Liu ,  Peter Meinke ,  Ravi Natarajan ,  William Parsons ,  Dong-Ming Shen ,  Min Shu ,  John Stelmach ,  Harold Wood ,  Fengqi Zhang ,  David Wisnoski ,  James Doherty

发明人： Meng Hsin Chen ,  Luping Liu ,  Peter Meinke ,  Ravi Natarajan ,  William Parsons ,  Dong-Ming Shen ,  Min Shu ,  John Stelmach ,  Harold Wood ,  Fengqi Zhang ,  David Wisnoski ,  James Doherty

IPC分类号： A61K9/08 ,  A61K9/10 ,  A61K31/404 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/7056 ,  A61K45/00 ,  A61K47/36 ,  A61P3/10 ,  A61P9/06 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P27/12 ,  A61P43/00 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/18 ,  C07D401/06 ,  C07D403/10 ,  C07D409/12 ,  C07D413/02 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07H15/26 ,  C07D43/02

CPC分类号： C07D401/06 ,  C07D209/12 ,  C07D209/18 ,  C07D403/10 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07H15/26

摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

公开(公告)号：US4475731A

公开(公告)日：1984-10-09

申请号：US450806

申请日：1982-12-17

申请人： Harold Wood

发明人： Harold Wood

IPC分类号： B65H3/00 ,  B41J13/00 ,  B41J13/10 ,  B65H3/06 ,  B65H3/44 ,  B65H31/22 ,  G06K15/16 ,  B65H5/26

CPC分类号： B65H31/22 ,  B41J13/103 ,  B65H3/44 ,  B65H2301/42328

摘要： A mechanical system for feeding cut sheet paper to a printer from one of several cassettes. A mechanical selector is mounted in each cassette so that it can drive a paper feed roll mounted in that cassette. The cassettes include insert guides which allow each cassette to be replaceably mounted in at least one side rail secured on the printer. The side rail has guides that receive and automatically locate each cassette on the printer with a simple "drop in" engagement. The side rail supports a gear train or an equivalent power transmission arrangement that has a common drive and extends to all of the cassettes. A power input gear of each selector engages an associated gear of the gear train. The selectors each include a combination mechanism that allows the selector to transmit power only after the drive shaft has supplied a programmed pattern of rotations and counter-rotations to the selectors. A unique association between the programmed pattern of rotations and the selection of a given cassette is established either by varying the "combinations" of the selectors or by using the same combination but varying the gear ratio between the drive shaft and the power input gear of the selector.

摘要翻译： 一种用于从多个盒中的一个将打印纸送入打印机的机械系统。 机械选择器安装在每个盒中，以便它可以驱动安装在该盒中的送纸辊。 盒带包括插入引导件，其允许每个盒可更换地安装在固定在打印机上的至少一个侧轨中。 侧轨具有引导，可以简单地“下降”接合并自动定位打印机上的每个卡带。 侧轨支撑齿轮系或具有公共驱动并延伸到所有盒的等效动力传动装置。 每个选择器的动力输入齿轮接合齿轮系的相关齿轮。 选择器各自包括组合机构，其允许选择器仅在驱动轴向选择器提供编程的旋转和反向旋转模式之后才发射功率。 通过改变选择器的“组合”或通过使用相同的组合但改变驱动轴和动力输入齿轮之间的传动比来建立编程的旋转模式和给定盒的选择之间的独特关联 选择器。