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公开(公告)号：US20050208514A1
公开(公告)日：2005-09-22
申请号：US10980659
申请日：2004-11-03
申请人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
发明人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译： 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。
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公开(公告)号：US20060094647A1
公开(公告)日：2006-05-04
申请号：US09992840
申请日：2001-11-06
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
IPC分类号： A61K38/17
CPC分类号： A61K38/1825 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译： 本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。 在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。 类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。
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公开(公告)号：US20050063971A1
公开(公告)日：2005-03-24
申请号：US10948588
申请日：2004-09-23
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P7/06 , A61P9/00 , A61P17/02 , A61P17/14 , A61P35/00 , A61P43/00 , C07K14/50 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07K16/28
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20050256039A1
公开(公告)日：2005-11-17
申请号：US10842206
申请日：2004-05-10
申请人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
发明人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
CPC分类号： A61K38/1825 , C07K14/50
摘要： The present invention relates to compositions and methods of treatment of various conditions, including but are not limited to, stroke, wound healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis). More particularly, the present invention relates to compositions comprising a member of the fibroblast growth factor family, FGF-CX (also known as CG53135-05 or FGF-20), its related polypeptides, nucleic acids encoding such polypeptides, and their uses for treating a condition, such as but is not limited to, stroke, would healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis).
摘要翻译： 本发明涉及治疗各种病症的组合物和方法，包括但不限于中风，伤口愈合和关节疾病（例如骨关节炎和类风湿性关节炎）。 更具体地，本发明涉及包含成纤维细胞生长因子家族成员，FGF-CX（也称为CG53135-05或FGF-20）的成员，其相关多肽，编码这些多肽的核酸及其用于治疗 一种情况，例如但不限于中风，会愈合，以及关节疾病（例如骨关节炎和类风湿性关节炎）。
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公开(公告)号：US07253266B2
公开(公告)日：2007-08-07
申请号：US10174394
申请日：2002-06-17
申请人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
发明人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
CPC分类号： C07K14/50 , A61K38/1825 , A61K48/00 , A61K2039/505 , Y10S435/975
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20080287349A1
公开(公告)日：2008-11-20
申请号：US10980458
申请日：2004-11-03
申请人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
发明人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
IPC分类号： A61K38/17 , A61K31/711 , C07H21/04 , C12N15/63 , C12N5/06 , C12N1/00 , C12P21/00 , C07K14/00 , A61P19/00 , A61P19/02
CPC分类号： A61K38/1825 , A61K31/711 , C07K14/50
摘要： The present invention relates to compositions and methods for preventing and treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases). More particularly, the present invention provides methods for preventing and/or treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases) by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译： 本发明涉及用于预防和治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的组合物和方法。 更具体地，本发明通过使用包含FGF的组合物提供了预防和/或治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的方法 -20，片段，衍生物，变体，同系物或其类似物。
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公开(公告)号：US20050171020A1
公开(公告)日：2005-08-04
申请号：US11096308
申请日：2005-04-01
摘要： Disclosed are novel nucleic acids encoding proteins and polypeptides related to bone morphogenetic protein-1 (BMF1) and to vascular endothelial growth factor E (VEGF-E).
摘要翻译： 公开了编码与骨形态发生蛋白-1（BMF1）和血管内皮生长因子E（VEGF-E）相关的蛋白质和多肽的新型核酸。
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公开(公告)号：US07056885B1
公开(公告)日：2006-06-06
申请号：US09609543
申请日：2000-07-03
申请人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods of use for the FGF-CX polypeptide, polynucleotide and antibody.
摘要翻译： 本发明提供FGF-CX多肽和多核苷酸，以及免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明另外提供了用于FGF-CX多肽，多核苷酸和抗体的方法。
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公开(公告)号：US20050164929A1
公开(公告)日：2005-07-28
申请号：US10980764
申请日：2004-11-03
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52 , A61K48/00 , A61K38/17
摘要： The present invention relates to compositions and methods for preventing and treating an inflammatory disorder of a mucosa, including but is not limited to, inflammatory bowel disease and irritable bowel syndrome. More particularly, the present invention relates to compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof, and their uses in preventing and treating an inflammatory disorder of a mucosa, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译： 本发明涉及用于预防和治疗粘膜炎症性疾病的组合物和方法，包括但不限于炎性肠病和肠易激综合征。 更具体地，本发明涉及包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物，以及它们在预防和治疗粘膜炎症性疾病如炎症性肠病中的用途 或肠易激综合征。
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公开(公告)号：US20050256042A1
公开(公告)日：2005-11-17
申请号：US10980459
申请日：2004-11-03
申请人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
发明人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
摘要： The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for preventing and/or treating alimetary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译： 本发明涉及预防和治疗消化性粘膜炎的组合物和方法。 更具体地，本发明提供了通过使用包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物来预防和/或治疗哺乳动物粘膜炎的方法。
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