Polynucleotides and proteins encoded thereby
    4.
    发明授权
    Polynucleotides and proteins encoded thereby 失效
    由此编码的多核苷酸和蛋白质

    公开(公告)号:US06863889B2

    公开(公告)日:2005-03-08

    申请号:US09957187

    申请日:2001-09-19

    摘要: The present invention provides novel isolated SECX polynucleotides and the membrane-associated or selected polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provide methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

    摘要翻译: 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或选择的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽,多核苷酸或抗体的任何衍生物,变体,突变体或片段的抗体。 本发明还提供了其中SECX多肽,多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

    Treatment of inflammatory bowel disease using fibroblast growth factor CX polypeptides
    7.
    发明授权
    Treatment of inflammatory bowel disease using fibroblast growth factor CX polypeptides 失效
    使用成纤维细胞生长因子CX多肽治疗炎症性肠病

    公开(公告)号:US07189693B2

    公开(公告)日:2007-03-13

    申请号:US10321962

    申请日:2002-12-16

    IPC分类号: A61K38/00 C07K14/00

    CPC分类号: A61K38/1825 A61K38/1858

    摘要: The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. The invention includes methods of reducing the mortality rate or delaying mortality in a subject suffering from an inflammatory pathology. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotides sequences and the FGF-CX polypeptides encoded by such nucleic acid sequence, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.

    摘要翻译: 本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。 本发明包括降低患有炎性病理学的患者的死亡率或延缓死亡率的方法。 在本发明中要求使用成纤维细胞生长因子CX(FGF-CX)多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体,片段和同系物的方法。 类似地,在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽,或其变体,片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种,分别为FCTR1,FCTR2,FCTR3,FCTR4,FCTR5和FCTR6。