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公开(公告)号：US07253266B2
公开(公告)日：2007-08-07
申请号：US10174394
申请日：2002-06-17
申请人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
发明人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
CPC分类号： C07K14/50 , A61K38/1825 , A61K48/00 , A61K2039/505 , Y10S435/975
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US07056885B1
公开(公告)日：2006-06-06
申请号：US09609543
申请日：2000-07-03
申请人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods of use for the FGF-CX polypeptide, polynucleotide and antibody.
摘要翻译： 本发明提供FGF-CX多肽和多核苷酸，以及免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明另外提供了用于FGF-CX多肽，多核苷酸和抗体的方法。
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公开(公告)号：US20080287349A1
公开(公告)日：2008-11-20
申请号：US10980458
申请日：2004-11-03
申请人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
发明人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
IPC分类号： A61K38/17 , A61K31/711 , C07H21/04 , C12N15/63 , C12N5/06 , C12N1/00 , C12P21/00 , C07K14/00 , A61P19/00 , A61P19/02
CPC分类号： A61K38/1825 , A61K31/711 , C07K14/50
摘要： The present invention relates to compositions and methods for preventing and treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases). More particularly, the present invention provides methods for preventing and/or treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases) by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译： 本发明涉及用于预防和治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的组合物和方法。 更具体地，本发明通过使用包含FGF的组合物提供了预防和/或治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的方法 -20，片段，衍生物，变体，同系物或其类似物。
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公开(公告)号：US06863889B2
公开(公告)日：2005-03-08
申请号：US09957187
申请日：2001-09-19
摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or selected polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provide methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或选择的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。
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5.发明授权Assay and kit for the detection of .alpha. platelet derived growth factor receptor 失效用于检测α血小板衍生生长因子受体的测定和试剂盒
公开(公告)号：US5863739A
公开(公告)日：1999-01-26
申请号：US460069
申请日：1995-06-02
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K51/00 , A61K51/10 , C07K14/71 , C07K16/22 , C07K16/28 , C07K16/46 , C12N5/20 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/566 , G01N33/577 , G01N33/74
CPC分类号： C07K14/71 , A61K51/103 , C07K16/22 , C07K16/2863 , G01N33/566 , G01N33/74 , A61K2123/00 , A61K38/00 , C07K2317/77 , C07K2319/30 , G01N2333/49 , G01N2333/71
摘要： Potent neutralizing monoclonal antibodies to the human .alpha. PDGF receptor (.alpha. PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on .alpha. PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind .beta. PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing .alpha. PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of .alpha. PDGFR and for evaluating the binding affinity of a test compound are also described.
摘要翻译： 描述了对人αPDGF受体（αPDGFR）及其片段的强中和单克隆抗体。 这些单克隆抗体特异性结合αPDGFR上的表位，抑制PDGF与PDGF的结合，拮抗PDGF，并且不结合β-PDGFR受体。 还描述了使用这些单克隆抗体的产生这种单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的体内成像病理学条件和抑制表达αPDGFR的瘤形成的方法的方法。 还描述了用于检测αPDGFR的存在和用于评估测试化合物的结合亲和力的体外测定。
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6.发明授权Method for making a monoclonal antibody, monoclonal antibodies to .alpha. P D 失效制备单克隆抗体的方法，针对α-PDGFR的单克隆抗体和体内成像方法
公开(公告)号：US5468468A
公开(公告)日：1995-11-21
申请号：US81216
申请日：1993-06-25
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K51/00 , A61K51/10 , C07K14/71 , C07K16/22 , C07K16/28 , C07K16/46 , C12N5/20 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/566 , G01N33/577 , G01N33/74 , G01N33/58 , C12N5/12
CPC分类号： C07K14/71 , A61K51/103 , C07K16/22 , C07K16/2863 , G01N33/566 , G01N33/74 , A61K2123/00 , A61K38/00 , C07K2317/77 , C07K2319/30 , G01N2333/49 , G01N2333/71
摘要： Potent neutralizing monoclonal antibodies to the human .alpha. PDGF receptor (.alpha. PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on .alpha. PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind .beta. PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing .alpha. PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of .alpha. PDGFR and for evaluating the binding affinity of a test compound are also described.
摘要翻译： 描述了对人αPDGF受体（αPDGFR）及其片段的强中和单克隆抗体。 这些单克隆抗体特异性结合αPDGFR上的表位，抑制PDGF与PDGF的结合，拮抗PDGF，并且不结合β-PDGFR受体。 还描述了使用这些单克隆抗体的产生这种单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的体内成像病理学条件和抑制表达αPDGFR的瘤形成的方法的方法。 还描述了用于检测αPDGFR的存在和用于评估测试化合物的结合亲和力的体外测定。
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7.发明授权Treatment of inflammatory bowel disease using fibroblast growth factor CX polypeptides 失效使用成纤维细胞生长因子CX多肽治疗炎症性肠病公开(公告)号：US07189693B2
公开(公告)日：2007-03-13
申请号：US10321962
申请日：2002-12-16
CPC分类号： A61K38/1825 , A61K38/1858
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. The invention includes methods of reducing the mortality rate or delaying mortality in a subject suffering from an inflammatory pathology. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotides sequences and the FGF-CX polypeptides encoded by such nucleic acid sequence, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译： 本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。 本发明包括降低患有炎性病理学的患者的死亡率或延缓死亡率的方法。 在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。 类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。
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8.发明授权Methods of inhibiting the growth of neoplasia using a monoclonal antibody against .alpha. platelet derived growth factor receptor 失效使用针对α血小板衍生生长因子受体的单克隆抗体抑制肿瘤生长的方法
公开(公告)号：US5833986A
公开(公告)日：1998-11-10
申请号：US460279
申请日：1995-06-02
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K51/00 , A61K51/10 , C07K14/71 , C07K16/22 , C07K16/28 , C07K16/46 , C12N5/20 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/566 , G01N33/577 , G01N33/74 , C07K16/30
CPC分类号： C07K14/71 , A61K51/103 , C07K16/22 , C07K16/2863 , G01N33/566 , G01N33/74 , A61K2123/00 , A61K38/00 , C07K2317/77 , C07K2319/30 , G01N2333/49 , G01N2333/71
摘要： Potent neutralizing monoclonal antibodies to the human .alpha. PDGF receptor (.alpha. PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on .alpha. PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind .beta. PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing .alpha. PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of .alpha. PDGFR and for evaluating the binding affinity of a test compound are also described.
摘要翻译： 描述了对人αPDGF受体（αPDGFR）及其片段的强中和单克隆抗体。 这些单克隆抗体特异性结合αPDGFR上的表位，抑制PDGF与PDGF的结合，拮抗PDGF，并且不结合β-PDGFR受体。 还描述了使用这些单克隆抗体的产生这种单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的体内成像病理学条件和抑制表达αPDGFR的瘤形成的方法的方法。 还描述了用于检测αPDGFR的存在和用于评估测试化合物的结合亲和力的体外测定。
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