公开(公告)号：US20170238808A1

公开(公告)日：2017-08-24

申请号：US15434758

申请日：2017-02-16

申请人： John B. SIMPSON ,  Himanshu N. PATEL ,  Michael ZUNG ,  Charles W. MCNALL ,  Priyanshu GUPTA ,  Maegan K. SPENCER ,  Christopher B. WHITE ,  Dennis W. JACKSON ,  John F. BLACK

发明人： John B. SIMPSON ,  Himanshu N. PATEL ,  Michael ZUNG ,  Charles W. MCNALL ,  Priyanshu GUPTA ,  Maegan K. SPENCER ,  Christopher B. WHITE ,  Dennis W. JACKSON ,  John F. BLACK

IPC分类号： A61B5/00 ,  A61B90/00 ,  A61B8/08 ,  A61B6/12 ,  A61B6/00 ,  A61B17/3207 ,  A61B5/02

CPC分类号： A61B5/0084 ,  A61B5/0035 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/4836 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/485 ,  A61B6/487 ,  A61B8/0841 ,  A61B17/32002 ,  A61B17/320758 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00057 ,  A61B2017/003 ,  A61B2017/00778 ,  A61B2017/22068 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2090/3735 ,  A61B2090/376 ,  A61B2090/3966 ,  A61B2090/3983 ,  A61B2217/007 ,  A61B2562/0233 ,  F04C2270/0421

摘要： A catheter device for crossing occlusions includes an elongate body, a central lumen extending within the elongate body from the proximal end to the distal end, a rotatable tip at the distal end of the elongate body, and an OCT imaging sensor. The rotatable tip is configured to rotate relative to the elongate body. The OCT imaging sensor includes an optical fiber coupled with the rotatable tip and configured to rotate therewith. A distal end of the elongate body includes one or more markers configured to occlude the OCT imaging sensor as it rotates. A fixed jog in the elongate body proximal to the distal end of the catheter positions the distal end of the catheter at an angle relative to the region of the catheter proximal to the fixed jog and is aligned with the one or more markers on the elongate body.

公开(公告)号：US20140213893A1

公开(公告)日：2014-07-31

申请号：US14171583

申请日：2014-02-03

申请人： John B. SIMPSON ,  Himanshu N. PATEL ,  Michael ZUNG ,  Charles W. MCNALL ,  Priyanshu GUPTA ,  Maegan K. SPENCER ,  Christopher B. WHITE ,  Dennis W. JACKSON ,  John F. BLACK

发明人： John B. SIMPSON ,  Himanshu N. PATEL ,  Michael ZUNG ,  Charles W. MCNALL ,  Priyanshu GUPTA ,  Maegan K. SPENCER ,  Christopher B. WHITE ,  Dennis W. JACKSON ,  John F. BLACK

IPC分类号： A61B5/00 ,  A61B17/32 ,  A61B6/00 ,  A61B19/00 ,  A61B17/3207 ,  A61B6/12

CPC分类号： A61B5/0084 ,  A61B5/0035 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/4836 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/485 ,  A61B6/487 ,  A61B8/0841 ,  A61B17/32002 ,  A61B17/320758 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00057 ,  A61B2017/003 ,  A61B2017/00778 ,  A61B2017/22068 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2090/3735 ,  A61B2090/376 ,  A61B2090/3966 ,  A61B2090/3983 ,  A61B2217/007 ,  A61B2562/0233 ,  F04C2270/0421

摘要： A catheter device for crossing occlusions includes an elongate body, a central lumen extending within the elongate body from the proximal end to the distal end, a rotatable tip at the distal end of the elongate body, and an OCT imaging sensor. The rotatable tip is configured to rotate relative to the elongate body. The OCT imaging sensor includes an optical fiber coupled with the rotatable tip and configured to rotate therewith. A distal end of the elongate body includes one or more markers configured to occlude the OCT imaging sensor as it rotates. A fixed jog in the elongate body proximal to the distal end of the catheter positions the distal end of the catheter at an angle relative to the region of the catheter proximal to the fixed jog and is aligned with the one or more markers on the elongate body.

摘要翻译： 用于穿过闭塞的导管装置包括细长主体，在细长主体内从近端延伸到远端延伸的中心腔，在细长主体的远端处的可旋转尖端，以及OCT成像传感器。 可旋转尖端构造成相对于细长主体旋转。 OCT成像传感器包括与可旋转尖端连接并被配置为随其旋转的光纤。 细长体的远端包括一个或多个标记，其构造成在OCT旋转时封闭OCT成像传感器。 在靠近导管远端的细长体中的固定慢跑将导管的远端相对于导管的邻近固定点动的区域以一定角度定位，并与细长体上的一个或多个标记对准 。

公开(公告)号：US20130296695A1

公开(公告)日：2013-11-07

申请号：US13939161

申请日：2013-07-10

申请人： Maegan K. SPENCER ,  Christopher B. WHITE ,  Charles W. MCNALL ,  Dennis W. JACKSON ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Benjamin NGO ,  Evangeline LUMABAS ,  Kin F. CHAN ,  John F. BLACK ,  Michael H. ROSENTHAL ,  John B. SIMPSON

发明人： Maegan K. SPENCER ,  Christopher B. WHITE ,  Charles W. MCNALL ,  Dennis W. JACKSON ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Benjamin NGO ,  Evangeline LUMABAS ,  Kin F. CHAN ,  John F. BLACK ,  Michael H. ROSENTHAL ,  John B. SIMPSON

IPC分类号： A61B5/00

摘要： A system for imaging a body lumen includes a controller and a display. The controller is configured to connect to a proximal end of a catheter having an optical fiber extending along the length of an elongate catheter body. The controller is further configured to rotate a distal end of the optical fiber from a location near a proximal end of the elongate catheter body, acquire optical coherence tomography (OCT) images using the optical fiber as the distal end of the optical fiber rotates, and determine a rotational lag of the distal end of the optical fiber. The display is configured to display one or more OCT images corrected for the rotational lag.

摘要翻译： 用于对体腔成像的系统包括控制器和显示器。 控制器被配置为连接到具有沿着细长导管主体的长度延伸的光纤的导管的近端。 所述控制器进一步构造成从所述细长导管主体的近端附近的位置旋转所述光纤的远端，当所述光纤的远端旋转时，使用所述光纤采集光学相干断层摄影（OCT）图像;以及 确定光纤远端的旋转滞后。 显示器被配置为显示针对旋转滞后校正的一个或多个OCT图像。

公开(公告)号：US20160262791A1

公开(公告)日：2016-09-15

申请号：US15162330

申请日：2016-05-23

申请人： Himanshu N. PATEL ,  John B. SIMPSON ,  Charles W. McNALL ,  Maegan K. SPENCER ,  Michael ZUNG ,  Priyanshu GUPTA

发明人： Himanshu N. PATEL ,  John B. SIMPSON ,  Charles W. McNALL ,  Maegan K. SPENCER ,  Michael ZUNG ,  Priyanshu GUPTA

IPC分类号： A61B17/3207

CPC分类号： A61B17/320783 ,  A61B1/00165 ,  A61B1/00179 ,  A61B1/00183 ,  A61B1/3137 ,  A61B5/0066 ,  A61B17/320725 ,  A61B17/320758 ,  A61B90/37 ,  A61B2017/00292 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61B2090/3735

摘要： Described herein are atherectomy catheters, systems and methods that include longitudinally displaceable drive shafts that drive actuation of one or more cutters at the distal end of the catheter. The catheters described herein may include one or more imaging sensors for imaging before, during or after cutting tissue. In some variations the imaging sensor may be rotated around the perimeter of the catheter independently of the rotation of the cutter. Also describe herein are imaging catheters that may be used without cutters.

摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括在导管的远端驱动一个或多个切割器的致动的可纵向移位的驱动轴。 本文所述的导管可以包括用于在切割组织之前，期间或之后成像的一个或多个成像传感器。 在一些变型中，成像传感器可以围绕导管的周边旋转，而与切割器的旋转无关。 这里还描述了可以在没有切割器的情况下使用的成像导管。

公开(公告)号：US20180049700A1

公开(公告)日：2018-02-22

申请号：US15783800

申请日：2017-10-13

申请人： John F. BLACK ,  Maegan K. SPENCER ,  Michael ZUNG ,  Charles W. MCNALL ,  Evangeline LUMABAS ,  Michael H. ROSENTHAL ,  John B. SIMPSON

发明人： John F. BLACK ,  Maegan K. SPENCER ,  Michael ZUNG ,  Charles W. MCNALL ,  Evangeline LUMABAS ,  Michael H. ROSENTHAL ,  John B. SIMPSON

IPC分类号： A61B5/00

CPC分类号： A61B5/6852 ,  A61B5/0066

摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.

公开(公告)号：US20170065293A1

公开(公告)日：2017-03-09

申请号：US15354898

申请日：2016-11-17

申请人： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

发明人： Michael H. ROSENTHAL ,  Michael ZUNG ,  Nicholas J. SPINELLI ,  Charles W. McNALL ,  John B. SIMPSON ,  John F. BLACK

IPC分类号： A61B17/3207 ,  A61B90/00

CPC分类号： A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

公开(公告)号：US20130123615A1

公开(公告)日：2013-05-16

申请号：US13675867

申请日：2012-11-13

申请人： Maegan K. SPENCER ,  John B. SIMPSON ,  Stephen C. DAVIES

发明人： Maegan K. SPENCER ,  John B. SIMPSON ,  Stephen C. DAVIES

IPC分类号： A61B5/00 ,  A61B17/3207

CPC分类号： A61B34/20 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/487 ,  A61B17/00234 ,  A61B17/320725 ,  A61B17/320758 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00296 ,  A61B2017/22068 ,  A61B2034/2055 ,  A61B2034/2065 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2090/3735 ,  A61B2217/007 ,  A61B2562/0233

摘要： Described herein are methods for producing and identifying characteristic (“crescent shaped”) regions indicative of an atherectomy plaque within a vessel, and systems and devices adapted to take advantage of this characteristic region.

摘要翻译： 这里描述的是用于产生和识别指示血管内的粥样斑块切除斑块的特征（“新月形”）区域的方法，以及适于利用该特征区域的系统和装置。

公开(公告)号：US20160262839A1

公开(公告)日：2016-09-15

申请号：US15162353

申请日：2016-05-23

申请人： Maegan K. SPENCER ,  John B. SIMPSON ,  Stephen C. DAVIES

发明人： Maegan K. SPENCER ,  John B. SIMPSON ,  Stephen C. DAVIES

IPC分类号： A61B34/20 ,  A61B17/00 ,  A61B17/3207

CPC分类号： A61B34/20 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/487 ,  A61B17/00234 ,  A61B17/320725 ,  A61B17/320758 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00296 ,  A61B2017/22068 ,  A61B2034/2055 ,  A61B2034/2065 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2090/3735 ,  A61B2217/007 ,  A61B2562/0233

摘要： Described herein are methods for producing and identifying characteristic (“crescent shaped”) regions indicative of an atherectomy plaque within a vessel, and systems and devices adapted to take advantage of this characteristic region.

摘要翻译： 本文描述了用于产生和识别指示血管内斑块的特征（“新月形”）区域的方法，以及适于利用该特征区域的系统和装置。

公开(公告)号：US20180256187A1

公开(公告)日：2018-09-13

申请号：US15922058

申请日：2018-03-15

申请人： Himanshu N. PATEL ,  John B. SIMPSON

发明人： Himanshu N. PATEL ,  John B. SIMPSON

IPC分类号： A61B17/32 ,  A61B17/3207 ,  A61B17/00 ,  A61B17/22 ,  A61B18/14 ,  A61B18/24

CPC分类号： A61B17/32002 ,  A61B17/22012 ,  A61B17/32075 ,  A61B17/320758 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00336 ,  A61B2017/00398 ,  A61B2017/22094

摘要： A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheter's rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheath's helical grooves or slots against the cutting head's protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.

公开(公告)号：US20180042520A1

公开(公告)日：2018-02-15

申请号：US15480238

申请日：2017-04-05

申请人： Himanshu N. PATEL ,  John B. SIMPSON

发明人： Himanshu N. PATEL ,  John B. SIMPSON

IPC分类号： A61B5/06 ,  A61M25/01 ,  A61B17/3207 ,  A61B17/22 ,  A61B17/00

摘要： A catheter for positioning a guidewire across an occluded portion of a vessel includes an elongate catheter body, an integrated rotatable distal tip, a proximal handle region, and a catheter lumen extending through the elongate catheter body. The elongate body has a distal region configured to be bent to a set angle. The integrated rotatable distal tip includes one or more channeled flutes extending around the distal tip that are configured to be rotated in a first direction to dissect tissue and a second direction for bluntly contacting tissue. A proximal handle region includes a control for rotating the distal tip in either the first or second directions. The catheter lumen is configured to pass a guidewire.