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    Nitinol alloy design for improved mechanical stability and broader superelastic operating window
    1.
    发明申请
    Nitinol alloy design for improved mechanical stability and broader superelastic operating window 审中-公开
    镍钛诺合金设计提高了机械稳定性和更宽的超弹性操作窗口

    公开(公告)号：US20060086440A1

    公开(公告)日：2006-04-27

    申请号：US11019495

    申请日：2004-12-20

    申请人： John Boylan ,  Zhicheng Lin ,  Kent Stalker

    发明人： John Boylan ,  Zhicheng Lin ,  Kent Stalker

    IPC分类号： A61F2/82 ,  C22C14/00

    CPC分类号： C22C30/00 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/16 ,  C22C14/00 ,  C22C19/00 ,  C22F1/006

    摘要： A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron, aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expressed as UP=(0.66 ksi/° C.)(T)+σ0, with R2≧0.98, wherein σ0 is the upper plateau stress of the alloy at about 0° C., R2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.

    摘要翻译： 具有大的，超弹性的工作温度窗口或范围的镍钛合金。 镍 - 钛合金至少包括一种额外的元素，例如铂，钯，锰，硼，铝，钨和/或锆。 当通过热处理和面积还原步骤进行加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66 ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口 ）+σσ0，其中R 2≥0.98，其中σ0是在约0℃的合金的上平台应力。 R 2是确定系数，UP是合金的上平台应力。

    Stent delivery catheter system and method of implanting a self-expanding stent with embolic protection
    2.
    发明授权
    Stent delivery catheter system and method of implanting a self-expanding stent with embolic protection 有权
    支架输送导管系统和植入具有栓塞保护的自扩张支架的方法

    公开(公告)号：US08323327B2

    公开(公告)日：2012-12-04

    申请号：US12857467

    申请日：2010-08-16

    申请人： Nianjiong Joan Bei ,  Keif Fitzgerald ,  Patrick C. Saxton ,  Zhicheng Lin ,  Steven A. Tyler ,  Joanna Lubas

    发明人： Nianjiong Joan Bei ,  Keif Fitzgerald ,  Patrick C. Saxton ,  Zhicheng Lin ,  Steven A. Tyler ,  Joanna Lubas

    IPC分类号： A61F2/06

    CPC分类号： A61F2/958 ,  A61F2/013 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2002/9583 ,  A61F2230/0006 ,  A61F2230/008

    摘要： A catheter system for implanting an endoprosthesis at a treatment site in a patient's body lumen. The catheter includes an elongated shaft outer member and a stent sheath distal portion and a self-expanding stent radially restrained in a collapsed configuration within the stent sheath distal portion. A balloon catheter dimensioned for relative axial movement within the shaft outer member has an elongated shaft having an inflation lumen and a device receiving lumen. A stent stop secured to the balloon catheter is reversibly radially expandable to deploy from a collapsed to a radially expanded configuration. In the expanded configuration, the stent stop prevents longitudinal displacement of the stent. A balloon is located on a distal shaft section is releasably locked with respect to the shaft outer member and slidably disposed therein in an unlocked configuration.

    摘要翻译： 一种用于在患者体腔内的治疗部位植入内假体的导管系统。 导管包括细长轴外部构件和支架护套远端部分以及在扩张器护套远端部分中以收缩构型径向约束的自扩张支架。 用于在轴外部构件内进行相对轴向移动的气囊导管具有细长轴，该细长轴具有充气腔和容纳腔的装置。 固定到气囊导管的支架止动器可逆地径向展开，从展开状态展开到径向展开的构型。 在扩张结构中，支架止动件防止支架的纵向位移。 位于远侧轴部上的气囊相对于轴外部构件可释放地锁定并且以可解锁的构造可滑动地设置在其中。

    Methods for passivating metallic implantable medical devices including radiopaque markers
    4.
    发明授权
    Methods for passivating metallic implantable medical devices including radiopaque markers 有权
    用于钝化包括不透射线标记的金属可植入医疗装置的方法

    公开(公告)号：US08992761B2

    公开(公告)日：2015-03-31

    申请号：US13548908

    申请日：2012-07-13

    申请人： Zhicheng Lin

    发明人： Zhicheng Lin

    IPC分类号： C25F3/16 ,  A61F2/86

    CPC分类号： A61L31/18 ,  A61F2/86 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0054 ,  A61F2250/0098 ,  A61L31/022 ,  C25F3/16 ,  F04C2270/041

    摘要： The present disclosure is directed to methods of manufacturing and passivating stents and other implantable medical devices including one or more attached radiopaque markers. In one embodiment, the method includes providing a metallic implantable medical device body without any radiopaque marker(s) attached thereto, primary electropolishing the device body without any markers attached thereto, attaching one or more radiopaque markers to the device body, and lightly electropolishing the device including device body and attached radiopaque markers. Light electropolishing removes no more than about 5 percent by weight of the device (i.e., the device body and attached marker(s)). Light electropolishing passivates the exposed surfaces of the device body and markers, while also providing electropolishing to the region of any welds where the radiopaque marker(s) attach to the device body.

    摘要翻译： 本公开涉及制造和钝化支架和其它可植入医疗装置的方法，包括一个或多个附接的不透射线标记物。 在一个实施例中，该方法包括提供金属可植入医疗装置主体，而没有附接到其上的任何不透射线的标记，初次电抛光装置主体而没有附接到其上的任何标记，将一个或多个不透射线的标记附接到装置主体，以及轻轻电解抛光 装置包括装置主体和附接的不透射线标记。 轻质电解抛光消除不超过装置重量的约5％（即，装置主体和附着的标记）。 光电抛光钝化了器件主体和标记的暴露表面，同时还向不透射线标记附着到器件主体的任何焊缝的区域提供电抛光。

    METHODS FOR PASSIVATING METALLIC IMPLANTABLE MEDICAL DEVICES INCLUDING RADIOPAQUE MARKERS
    6.
    发明申请
    METHODS FOR PASSIVATING METALLIC IMPLANTABLE MEDICAL DEVICES INCLUDING RADIOPAQUE MARKERS 有权
    用于吞入金属可植入医疗器械的方法，包括无线电标记

    公开(公告)号：US20140014530A1

    公开(公告)日：2014-01-16

    申请号：US13548908

    申请日：2012-07-13

    申请人： Zhicheng Lin

    发明人： Zhicheng Lin

    IPC分类号： C25F3/16

    CPC分类号： A61L31/18 ,  A61F2/86 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0054 ,  A61F2250/0098 ,  A61L31/022 ,  C25F3/16 ,  F04C2270/041

    摘要： The present disclosure is directed to methods of manufacturing and passivating stents and other implantable medical devices including one or more attached radiopaque markers. In one embodiment, the method includes providing a metallic implantable medical device body without any radiopaque marker(s) attached thereto, primary electropolishing the device body without any markers attached thereto, attaching one or more radiopaque markers to the device body, and lightly electropolishing the device including device body and attached radiopaque markers. Light electropolishing removes no more than about 5 percent by weight of the device (i.e., the device body and attached marker(s)). Light electropolishing passivates the exposed surfaces of the device body and markers, while also providing electropolishing to the region of any welds where the radiopaque marker(s) attach to the device body.

    摘要翻译： 本公开涉及制造和钝化支架和其它可植入医疗装置的方法，包括一个或多个附接的不透射线标记物。 在一个实施例中，该方法包括提供金属可植入医疗装置主体，而没有附接到其上的任何不透射线的标记，初次电抛光装置主体而没有附接到其上的任何标记，将一个或多个不透射线的标记附接到装置主体，以及轻轻电解抛光 装置包括装置主体和附接的不透射线标记。 轻质电解抛光消除不超过装置重量的约5％（即，装置主体和附着的标记）。 光电抛光钝化了器件主体和标记的暴露表面，同时还向不透射线标记附着到器件主体的任何焊缝的区域提供电抛光。

    Fatigue-resistant nickel-titanium alloys and medical devices using same
    8.
    发明授权
    Fatigue-resistant nickel-titanium alloys and medical devices using same 有权
    耐疲劳镍钛合金和使用其的医疗器械

    公开(公告)号：US08398789B2

    公开(公告)日：2013-03-19

    申请号：US12324732

    申请日：2008-11-26

    申请人： Sophia L. Wong ,  Zhicheng Lin ,  Alan G. Tahran, Jr.

    发明人： Sophia L. Wong ,  Zhicheng Lin ,  Alan G. Tahran, Jr.

    IPC分类号： A61L27/06 ,  C22C14/00

    CPC分类号： B23P17/00 ,  A61L31/022 ,  A61L31/14 ,  A61L2400/16 ,  C08L2201/12 ,  C22C14/00 ,  C22C19/007 ,  C22C19/03 ,  C22F1/10 ,  Y10T29/49863

    摘要： Superelastic and/or shape memory nickel-titanium alloys having an increased fatigue life that is superior to known nickel-titanium alloys are disclosed. The nickel-titanium alloys have a minimum fatigue life that may be at least about 10 million strain cycles at a strain of at least about 0.75. The minimum fatigue life may be due, at least in part, to the nickel-titanium alloy having at least one of an oxygen concentration of less than about 200 ppm, a carbon concentration of less than about 200 ppm, the absence of oxide-based and/or carbide-based inclusions having a size greater than about 5 microns (μm), the presence of an R-phase, or combinations of the foregoing. Articles manufactured from such fatigue-resistant nickel-titanium alloys can be more durable because they are more resistant to repetitive strain and crack propagation.

    摘要翻译： 公开了具有优于已知镍 - 钛合金的疲劳寿命增加的超弹性和/或形状记忆镍钛合金。 镍钛合金具有最小的疲劳寿命，其在至少约0.75的应变下可能为至少约1000万个应变循环。 最小的疲劳寿命可能至少部分地归因于具有小于约200ppm的氧浓度，小于约200ppm的碳浓度，低于约200ppm的氧浓度的氧 - 和/或具有大于约5微米（μm）的尺寸的碳化物基夹杂物，R相的存在或前述的组合。 由这种耐疲劳镍钛合金制成的制品可以更耐用，因为它们更能抵抗重复的应变和裂纹扩展。