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1.发明申请Small Peptides And Methods For Treatment Of Chronic Inflammatory Bowel Disease 审中-公开小肽和治疗慢性炎症性肠病的方法公开(公告)号：US20120094938A1
公开(公告)日：2012-04-19
申请号：US13338990
申请日：2011-12-28
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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2.发明申请Small Peptides And Methods For Treatment Of Chronic Inflammatory Bowel Disease 审中-公开小肽和治疗慢性炎症性肠病的方法公开(公告)号：US20080214474A1
公开(公告)日：2008-09-04
申请号：US11942189
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Try-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Try-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US20080214472A1
公开(公告)日：2008-09-04
申请号：US11942160
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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4.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20120058958A1
公开(公告)日：2012-03-08
申请号：US13289393
申请日：2011-11-04
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
IPC分类号： A61K38/07 , C12N5/0787 , C12N5/0786 , A61K38/06 , A61P11/00 , A61P37/08 , A61P11/02 , A61P17/00 , A61P17/06 , A61P19/02 , C12N5/078 , A61P29/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of an immune cell, a method for stabilizing the cell membrane of an immune cell, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了抑制粘液释放到患者气道中的方法，用于阻止免疫细胞的IgE活化的方法，用于稳定免疫细胞的细胞膜的方法，从而防止其进一步参与增加的炎性反应 IgE抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US20080214477A1
公开(公告)日：2008-09-04
申请号：US11942229
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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6.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20080214476A1
公开(公告)日：2008-09-04
申请号：US11942213
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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7.发明申请公开(公告)号：US20080214475A1
公开(公告)日：2008-09-04
申请号：US11942202
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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8.发明申请Small Peptides And Methods For Stabilizing The Cell Membrane Of An Immune Cell 审中-公开小肽和稳定细胞免疫细胞膜的方法公开(公告)号：US20080187994A1
公开(公告)日：2008-08-07
申请号：US11942218
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
IPC分类号： C12N5/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US06391856B1
公开(公告)日：2002-05-21
申请号：US09190043
申请日：1998-11-10
申请人： John C. Houck , James Clagett
发明人： John C. Houck , James Clagett
IPC分类号： A61K3807
摘要： Methods for treating allergies, cutaneous inflammation, arthritis, chronic obstruction pulmonary disease and treating chronic inflammatory bowel disease are described. Also described is a method for inhibiting the infiltration of eosinophils into airways of a patient, a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte; thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗过敏，皮肤炎症，关节炎，慢性阻塞性肺疾病和治疗慢性炎症性肠病的方法。 还描述了一种抑制嗜酸性粒细胞浸润到患者气道中的方法，抑制对患者气道的粘液释放的方法，用于阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法 ; 从而防止其进一步参与对IgE抗原攻击的增加的炎症反应，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US08097589B2
公开(公告)日：2012-01-17
申请号：US11942202
申请日：2007-11-19
发明人： John C. Houck , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucus release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，用于阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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