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1.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20120058958A1
公开(公告)日：2012-03-08
申请号：US13289393
申请日：2011-11-04
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
IPC分类号： A61K38/07 , C12N5/0787 , C12N5/0786 , A61K38/06 , A61P11/00 , A61P37/08 , A61P11/02 , A61P17/00 , A61P17/06 , A61P19/02 , C12N5/078 , A61P29/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of an immune cell, a method for stabilizing the cell membrane of an immune cell, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了抑制粘液释放到患者气道中的方法，用于阻止免疫细胞的IgE活化的方法，用于稳定免疫细胞的细胞膜的方法，从而防止其进一步参与增加的炎性反应 IgE抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US20080214477A1
公开(公告)日：2008-09-04
申请号：US11942229
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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3.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20080214476A1
公开(公告)日：2008-09-04
申请号：US11942213
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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4.发明申请公开(公告)号：US20080214475A1
公开(公告)日：2008-09-04
申请号：US11942202
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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5.发明申请Small Peptides And Methods For Stabilizing The Cell Membrane Of An Immune Cell 审中-公开小肽和稳定细胞免疫细胞膜的方法公开(公告)号：US20080187994A1
公开(公告)日：2008-08-07
申请号：US11942218
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
IPC分类号： C12N5/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US06391856B1
公开(公告)日：2002-05-21
申请号：US09190043
申请日：1998-11-10
申请人： John C. Houck , James Clagett
发明人： John C. Houck , James Clagett
IPC分类号： A61K3807
摘要： Methods for treating allergies, cutaneous inflammation, arthritis, chronic obstruction pulmonary disease and treating chronic inflammatory bowel disease are described. Also described is a method for inhibiting the infiltration of eosinophils into airways of a patient, a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte; thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗过敏，皮肤炎症，关节炎，慢性阻塞性肺疾病和治疗慢性炎症性肠病的方法。 还描述了一种抑制嗜酸性粒细胞浸润到患者气道中的方法，抑制对患者气道的粘液释放的方法，用于阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法 ; 从而防止其进一步参与对IgE抗原攻击的增加的炎症反应，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US20150064163A1
公开(公告)日：2015-03-05
申请号：US14342561
申请日：2012-09-02
申请人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
CPC分类号： C07K14/51 , A61K38/1875 , A61K38/4826 , A61K38/4873 , A61K38/4886 , C07K2319/00 , C07K2319/23 , C07K2319/24 , C07K2319/50 , C07K2319/705 , C12N5/0654 , C12N5/0655 , C12N5/066 , C12N2501/155 , C12Y304/21004 , C12Y304/22008 , C12Y304/22038 , C12Y304/24004 , C12Y304/24007 , C12Y304/24019
摘要： The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
摘要翻译： 本发明涉及截短的生长因子及其变体。 本发明还涉及制备和使用截短的生长因子的方法。 本发明还涉及包含蛋白酶和包含骨形态发生蛋白（BMP）或其变体的生长因子的组合物。 本发明还涉及使用该组合物的方法。
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公开(公告)号：US20130196910A1
公开(公告)日：2013-08-01
申请号：US13636870
申请日：2011-03-24
申请人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
CPC分类号： C07K14/51 , A61K38/00 , A61K38/1875 , A61K38/48 , C12N5/0602 , C12N5/0658 , C12N9/48 , C12N2501/155
摘要： The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
摘要翻译： 本发明涉及截短的生长因子及其变体。 本发明还涉及制备和使用截短的生长因子的方法。
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公开(公告)号：US20130196909A1
公开(公告)日：2013-08-01
申请号：US13636869
申请日：2011-03-24
申请人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
CPC分类号： C07K14/51 , A61K38/1875 , A61K38/48 , C12N5/0602 , C12N9/48
摘要： The invention relates to truncated growth factors and variants thereof. The invention also relate to methods of making and using the truncated growth factors.
摘要翻译： 本发明涉及截短的生长因子及其变体。 本发明还涉及制备和使用截短的生长因子的方法。
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10.发明授权Small peptides and methods for inhibiting the infiltration of eosinophils into airways 失效用于抑制嗜酸性粒细胞浸润到气道中的小肽和方法公开(公告)号：US07994137B2
公开(公告)日：2011-08-09
申请号：US11942371
申请日：2007-11-19
发明人： John C. Houck , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, methods for blocking IgE activation and for stabilizing the cell membrane of lymphocytes, mast cells, basophils, macrophages, monocytes, eosinophils, neutrophils, and the like, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，用于阻断IgE活化和稳定淋巴细胞，肥大细胞，嗜碱性粒细胞，巨噬细胞，单核细胞，嗜酸性粒细胞，嗜中性粒细胞等的细胞膜的方法，从而防止其 进一步参与对IgE抗原攻击的增加的炎症反应，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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