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公开(公告)号：US08097589B2
公开(公告)日：2012-01-17
申请号：US11942202
申请日：2007-11-19
发明人： John C. Houck , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucus release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，用于阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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2.发明申请Small Peptides And Methods For Inhibiting The Infiltration Of Eosinophils Into Airways 失效小肽和抑制嗜酸性粒细胞浸润入气道的方法公开(公告)号：US20080214478A1
公开(公告)日：2008-09-04
申请号：US11942371
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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3.发明申请Amine-based and amide-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO)enzyme activity and VAP-1 mediated adhesion useful for treatment of diseases 审中-公开氨基脲敏感性胺氧化酶（SSAO）酶活性的胺类和酰胺类抑制剂以及可用于治疗疾病的VAP-1介导的粘附公开(公告)号：US20070078157A1
公开(公告)日：2007-04-05
申请号：US11602565
申请日：2006-11-20
申请人： Luisa Salter-Cid , Eric Wang , Mary MacDonald , Jingjing Zhao
发明人： Luisa Salter-Cid , Eric Wang , Mary MacDonald , Jingjing Zhao
IPC分类号： A61K31/4745 , A61K31/4704 , A61K31/40 , A61K31/16 , A61K31/165 , A61K31/137
CPC分类号： A61K31/135 , A61K31/137 , A61K31/165 , A61K31/44 , A61K31/4406 , A61K31/47 , A61K31/4745
摘要： Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.
摘要翻译： 公开了用于抑制氨基脲敏感性胺氧化酶（SSAO），也称为血管粘附蛋白-1（VAP-1）的组合物和方法。 所公开的化合物是含胺和含酰胺的化合物。 化合物和组合物可用于治疗疾病，包括炎症，炎性疾病和自身免疫性疾病。
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4.发明授权Small peptides and methods for inhibiting the infiltration of eosinophils into airways 失效用于抑制嗜酸性粒细胞浸润到气道中的小肽和方法公开(公告)号：US07994137B2
公开(公告)日：2011-08-09
申请号：US11942371
申请日：2007-11-19
发明人： John C. Houck , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, methods for blocking IgE activation and for stabilizing the cell membrane of lymphocytes, mast cells, basophils, macrophages, monocytes, eosinophils, neutrophils, and the like, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，用于阻断IgE活化和稳定淋巴细胞，肥大细胞，嗜碱性粒细胞，巨噬细胞，单核细胞，嗜酸性粒细胞，嗜中性粒细胞等的细胞膜的方法，从而防止其 进一步参与对IgE抗原攻击的增加的炎症反应，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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5.发明申请Small Peptides And Methods For Treatment Of Chronic Obstruction Pulmonary Disease 审中-公开小肽和慢性阻塞性肺疾病治疗方法公开(公告)号：US20080214473A1
公开(公告)日：2008-09-04
申请号：US11942172
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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6.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20120058958A1
公开(公告)日：2012-03-08
申请号：US13289393
申请日：2011-11-04
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
IPC分类号： A61K38/07 , C12N5/0787 , C12N5/0786 , A61K38/06 , A61P11/00 , A61P37/08 , A61P11/02 , A61P17/00 , A61P17/06 , A61P19/02 , C12N5/078 , A61P29/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of an immune cell, a method for stabilizing the cell membrane of an immune cell, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了抑制粘液释放到患者气道中的方法，用于阻止免疫细胞的IgE活化的方法，用于稳定免疫细胞的细胞膜的方法，从而防止其进一步参与增加的炎性反应 IgE抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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公开(公告)号：US20080214477A1
公开(公告)日：2008-09-04
申请号：US11942229
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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8.发明申请Small Peptides And Methods For Blocking IgE Mediated Activation Of An Immune Cell 审中-公开小肽和阻断IgE介导的免疫细胞活化的方法公开(公告)号：US20080214476A1
公开(公告)日：2008-09-04
申请号：US11942213
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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9.发明申请公开(公告)号：US20080214475A1
公开(公告)日：2008-09-04
申请号：US11942202
申请日：2007-11-19
申请人： John C. Houck , James Clagett , Mary MacDonald
发明人： John C. Houck , James Clagett , Mary MacDonald
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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10.发明申请Small Peptides And Methods For Stabilizing The Cell Membrane Of An Immune Cell 审中-公开小肽和稳定细胞免疫细胞膜的方法公开(公告)号：US20080187994A1
公开(公告)日：2008-08-07
申请号：US11942218
申请日：2007-11-19
申请人： John C. Houck , Mary MacDonald , James Clagett
发明人： John C. Houck , Mary MacDonald , James Clagett
IPC分类号： C12N5/00
摘要： Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
摘要翻译： 描述了治疗皮肤炎症的方法。 还描述了一种抑制粘液释放到患者气道中的方法，阻断淋巴细胞IgE活化的方法，用于稳定淋巴细胞的细胞膜的方法，从而防止其进一步参与IgE增加的炎症反应 抗原攻击，以及抑制T细胞迁移的方法。 这样的方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽，其中X选自Tyr，Tyr-Phe，Phe-Phe和Phe-Tyr。
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