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    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
    1.
    发明授权
    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 失效

    公开(公告)号：US07026292B1

    公开(公告)日：2006-04-11

    申请号：US09287500

    申请日：1999-04-07

    申请人： John C. Lee ,  Lee-Chuan C. Yeh

    发明人： John C. Lee ,  Lee-Chuan C. Yeh

    IPC分类号： A61K31/726 ,  A61K38/18 ,  A61K38/30 ,  C07K14/51 ,  C07K14/65

    CPC分类号： A61K9/0024 ,  A61K31/726 ,  A61K38/17 ,  A61K38/30 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

    Therapeutic methods using Smads
    2.
    发明申请
    Therapeutic methods using Smads 审中-公开
    使用Smads的治疗方法

    公开(公告)号：US20080293654A1

    公开(公告)日：2008-11-27

    申请号：US11499750

    申请日：2006-08-03

    申请人： John C. Lee ,  Lee-Chuan C. Yeh

    发明人： John C. Lee ,  Lee-Chuan C. Yeh

    IPC分类号： A61K31/7088 ,  C12N5/00 ,  A61P43/00

    CPC分类号： A61K38/1841 ,  A61K38/179 ,  A61K38/1875 ,  A61K2300/00

    摘要： Methods of inducing the expression of a Smad in a cell or tissue comprising the step of contacting the cell or tissue capable of expressing the Smad with a bone morphogenic protein are provided. Methods of inducing tissue formation and repairing a tissue defect or regenerating tissue, at a target locus in a mammal comprising the step of administering to the target locus a Smad are also provided.

    摘要翻译： 提供诱导细胞或组织中Smad表达的方法，包括使能够表达Smad的细胞或组织与骨形态发生蛋白接触的步骤。 还提供了在哺乳动物的靶标位点诱导组织形成和修复组织缺陷或再生组织的方法，所述方法包括向目标基因座施用Smad的步骤。

    Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements
    3.
    发明授权
    Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements 有权
    使用形态发生蛋白质反应性抑制元件鉴定形态发生蛋白类似物的方法和组合物

    公开(公告)号：US06368787B1

    公开(公告)日：2002-04-09

    申请号：US09465353

    申请日：1999-12-16

    申请人： Lee-Chuan C. Yeh ,  John C. Lee

    发明人： Lee-Chuan C. Yeh ,  John C. Lee

    IPC分类号： C12Q160

    CPC分类号： C12N15/1086 ,  C12Q1/6897 ,  Y10S530/84

    摘要： The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to the identified morphogenic protein analogs which can mimic the biological effects of morphogenic proteins, particularly those relating to the BMP family such as osteogenic protein (OP-1), on the regulation of gene expression and tissue inductive capabilities.

    摘要翻译： 本发明一般涉及用于鉴定形态发生蛋白类似物的方法和组合物。 在一个实施方案中，本发明涉及成骨蛋白反应转录抑制元件。 本发明还涉及可以模拟形态发生蛋白质，特别是与BMP家族（例如成骨蛋白质（OP-1）相关的那些）对调节基因表达和组织诱导能力的生物学效应的鉴定的形态发生蛋白类似物。

    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
    8.
    发明授权
    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 失效
    使用形态发生蛋白和刺激因子的组合物和治疗方法

    公开(公告)号：US6048964A

    公开(公告)日：2000-04-11

    申请号：US570752

    申请日：1995-12-12

    申请人： John C. Lee ,  Lee-Chuan C. Yeh

    发明人： John C. Lee ,  Lee-Chuan C. Yeh

    IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/20 ,  A61K31/202 ,  A61K31/565 ,  A61K31/57 ,  A61K31/573 ,  A61K31/59 ,  A61K38/00 ,  A61K38/18 ,  A61K38/27 ,  A61K38/28 ,  A61K38/30 ,  A61L24/10 ,  A61L27/00 ,  A61L27/22 ,  A61P19/00 ,  A61P43/00 ,  C12N5/10 ,  C12N7/00 ,  C12P21/02

    CPC分类号： A61L27/227 ,  A61K38/1875 ,  A61K38/30 ,  A61L24/108

    摘要： The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

    摘要翻译： 本发明提供包含形态发生蛋白质刺激因子（MPSF）的药物组合物，用于改善形态发生蛋白质，特别是属于BMP蛋白质家族的组织诱导活性。 提供了使用这些组合物改善哺乳动物中形态发生蛋白的组织诱导活性的方法。 本发明还提供了可植入形态发生装置，其包含形态发生蛋白和设置在载体内的MPSF，其能够诱导同种异体和异种植入物中的组织形成。 还提供了使用这些装置从哺乳动物的祖细胞诱导局部组织形成的方法。 提供了使用形态发生装置促进哺乳动物同种异体移植修复的方法。 本发明还提供了一种假体装置，其包括涂覆有形态发生蛋白质和MPSF的假体，以及用于促进可植入假体装置的体内整合以增强假体和接合部位的现有靶组织之间的结合强度的方法。 还提供了使用药物组合物治疗哺乳动物的组织退行病症的方法。