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公开(公告)号：US07585869B2
公开(公告)日：2009-09-08
申请号：US10849707
申请日：2004-05-20
申请人： Samit Kumar Bhattacharya , Jinshan Chen , Richard Damian Connell , John Charles Kath , Goss S. Kauffman , Blaise S. Lippa , Joel Morris
发明人： Samit Kumar Bhattacharya , Jinshan Chen , Richard Damian Connell , John Charles Kath , Goss S. Kauffman , Blaise S. Lippa , Joel Morris
IPC分类号： A61K31/517 , C07D239/94
CPC分类号： C07D401/12 , C07D239/94 , C07D405/14 , C07D471/04
摘要： The invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R11, N, Z, A, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1化合物及其药学上可接受的盐，前药和溶剂合物，其中R1，R3，R4，R11，N，Z，A，m和p如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06284764B1
公开(公告)日：2001-09-04
申请号：US09488350
申请日：2000-01-20
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31517
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06890924B2
公开(公告)日：2005-05-10
申请号：US09883752
申请日：2001-06-18
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/55 , A61K39/395 , A61K45/00 , A61P5/00 , A61P5/28 , A61P35/00 , A61P43/00 , C07D239/00 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
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公开(公告)号：US06541481B2
公开(公告)日：2003-04-01
申请号：US09834259
申请日：2001-04-12
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31505
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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5.发明授权公开(公告)号：US07332493B2
公开(公告)日：2008-02-19
申请号：US11079648
申请日：2005-03-14
IPC分类号： A61K31/517 , C07D239/84 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/538 , C07D413/12
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 3，R 4， R 5，R 11，m和p如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06927220B2
公开(公告)日：2005-08-09
申请号：US10121831
申请日：2002-04-12
申请人： Joel Morris , Samit K. Bhattacharya , John C. Kath
发明人： Joel Morris , Samit K. Bhattacharya , John C. Kath
IPC分类号： A61K31/519 , A61P9/00 , A61P9/14 , A61P35/00 , A61P35/04 , A61P43/00 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04
摘要： The invention relates to 6- or 7-bicyclic-substituted 4-amino-subsituted pyridopyrimidines and to pharmaceutically acceptable salts, prodrugs and hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating hyperproliferative disorders abnormal cell growth in a mammal by administering the compounds.
摘要翻译： 本发明涉及6-或7-双环取代的4-氨基取代的吡啶并嘧啶及其药学上可接受的盐，前药和水合物。 本发明还涉及含有这些化合物的药物组合物和通过施用化合物来治疗哺乳动物中过度增殖性疾病异常细胞生长的方法。
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公开(公告)号：US20090111805A1
公开(公告)日：2009-04-30
申请号：US11816509
申请日：2006-02-15
申请人： Joel Morris , Blaise Scott Lippa , Gonghua Pan , Goss Stryker Kauffman , Chao Li
发明人： Joel Morris , Blaise Scott Lippa , Gonghua Pan , Goss Stryker Kauffman , Chao Li
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/519 , C07D473/00 , A61K31/52 , A61K31/438 , C07D471/10
CPC分类号： C07D519/00
摘要： The invention relates to compounds of the formula I: and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, V, W, R4, R5, R6, R7, and ring B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I and to pharmaceutical compositions for treating such disorders which contain the compounds of formula I. The invention also relates to methods of preparing the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和溶剂化物，其中X，Z，V，W，R 4，R 5，R 6，R 7和环B如本文所定义。 本发明还涉及通过施用式I化合物治疗哺乳动物异常细胞生长的方法以及用于治疗含有式I化合物的这种病症的药物组合物。本发明还涉及制备式I化合物的方法。
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公开(公告)号：US07276602B2
公开(公告)日：2007-10-02
申请号：US10626406
申请日：2003-07-24
IPC分类号： C07D412/02 , C07D417/12
CPC分类号： C07D417/12
摘要： The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物或其药学上可接受的盐，前药，溶剂化物或水合物，其中X，R 1和R 2如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物中过度增殖性疾病的方法。
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9.发明申请公开(公告)号：US20050159435A1
公开(公告)日：2005-07-21
申请号：US11079648
申请日：2005-03-14
申请人： John Kath , Joel Morris , Samit Bhattacharya
发明人： John Kath , Joel Morris , Samit Bhattacharya
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/55 , A61K39/395 , A61K45/00 , A61P5/00 , A61P5/28 , A61P35/00 , A61P43/00 , C07D239/00 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D43/02
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 3，R 4， R 5，R 11，m和p如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06124306A
公开(公告)日：2000-09-26
申请号：US157975
申请日：1998-09-21
申请人： Joel Morris , Wade J. Adams , Janice M. Friis , Donn G. Wishka
发明人： Joel Morris , Wade J. Adams , Janice M. Friis , Donn G. Wishka
IPC分类号： C07D239/58 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P31/18 , C07D239/26 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/04 , C07D491/048 , C07D239/34
CPC分类号： C07D401/12 , C07D491/04
摘要： The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R.sub.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; andR.sub.6 is --S--C.sub.1-6 alkyl (preferably --SCH.sub.3);The compounds of Formula I are useful in the treatment of individuals who are HIV positive.
摘要翻译： 本发明涉及式I的嘧啶 - 硫代烷基和烷基醚化合物和式I的嘧啶 - 硫代烷基和烷基醚，其中R 4选自-H或-NR 15 R 16，其中R 15是-H且R 16是-H，C 1 -C 1-6烷基，-NH 2或R 15和R 16与-N形式的1-吡咯烷子基，1-吗啉代或1-哌啶子基一起使用; 并且R 6是-S-C 1-6烷基（优选-SCH 3）; 式I的化合物可用于治疗HIV阳性的个体。
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