公开(公告)号：US07211106B2

公开(公告)日：2007-05-01

申请号：US10763542

申请日：2004-01-23

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F7/00

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126 ,  A61M25/00 ,  A61M25/0023 ,  A61M2025/0004 ,  A61M2025/006 ,  A61M2205/3606

摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

公开(公告)号：US06679907B2

公开(公告)日：2004-01-20

申请号：US10210819

申请日：2002-07-31

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/0056 ,  A61F2007/126

摘要： The invention provides a method and device for heating or cooling a surrounding fluid in a feeding vessel. The device includes a catheter assembly capable of insertion to a selected feeding vessel in the vascular system of a patient. The assembly includes a heat transfer element at a distal end of the catheter assembly, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid, the surface irregularities having a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The assembly also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element, a return catheter to return a working fluid from the interior of the heat transfer element, and a drug delivery catheter running substantially parallel to the axis of the catheter assembly. The method includes selectively controlling the temperature of a selected volume of blood in a patient by introducing a catheter assembly into a blood vessel feeding a selected volume of blood in a patient and delivering a working fluid through a supply catheter in the catheter assembly and returning the working fluid through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. A liquid, such as a drug, is delivered through a drug delivery catheter to the volume of blood in the feeding vessel.

摘要翻译： 本发明提供一种用于加热或冷却进料容器中的周围流体的方法和装置。 该装置包括能够插入患者血管系统中的选定进料容器的导管组件。 所述组件包括在所述导管组件的远端处的传热元件，所述传热元件具有多个外表面凹凸，其形状和布置成在周围流体中产生湍流，所述表面凹凸具有至少等于边界的深度 进料容器中周围流体的流动层厚度。 该组件还包括供应导管，用于将工作流体输送到传热元件的内部;返回导管，用于从工作流体从传热元件的内部返回;以及药物输送导管，其基本上平行于 导管组件。 该方法包括通过将导管组件引入供给患者中选定体积的血液的血管中并通过导管组件中的供应导管输送工作流体来选择性地控制患者中所选体积的血液的温度， 工作流体通过导管组件中的返回导管。 在形成导管组件的远端的传热元件和进料容器中的血液体积之间传递热量。 诸如药物的液体通过药物输送导管递送到进料容器中的血液体积。

公开(公告)号：US08163000B2

公开(公告)日：2012-04-24

申请号：US11983946

申请日：2007-11-13

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126 ,  G05D23/1919 ,  G05D23/22 ,  G05D23/24

摘要： A guidable catheter for heating or cooling fluid in a feeding vessel in a vasculature of a patient includes a heat transfer element having exterior surface irregularities to create turbulence in a surrounding fluid. A supply catheter delivers a working fluid to an interior of the heat transfer element, and a return catheter returns a working fluid from the interior of the heat transfer element. A guidewire tube is provided adjacent one of the supply catheter or the return catheter and runs substantially parallel to the axis of the guidable catheter to receive a guidewire disposed within the guidewire tube. A temperature-monitoring device is disposed at the distal tip of the guidewire. Feedback is provided to control the temperature of a source of working fluid.

摘要翻译： 用于在患者脉管系统中的供给容器中加热或冷却流体的可引导导管包括具有外表面不规则性以在周围流体中产生湍流的传热元件。 供应导管将工作流体输送到传热元件的内部，并且返回导管从传热元件的内部返回工作流体。 在导管或返回导管之一附近提供导丝管，并且基本上平行于可导引导管的轴线延伸，以接纳设置在导丝管内的导丝。 温度监视装置设置在导丝的远端。 提供反馈来控制工作流体源的温度。

公开(公告)号：US06576001B2

公开(公告)日：2003-06-10

申请号：US10005056

申请日：2001-12-03

申请人： Randell L. Werneth ,  Kevin P. Gilmartin ,  Steven A. Yon ,  Juan C Lasheras ,  John D Dobak, III

发明人： Randell L. Werneth ,  Kevin P. Gilmartin ,  Steven A. Yon ,  Juan C Lasheras ,  John D Dobak, III

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/126

摘要： The invention provides a device for heating or cooling a surrounding fluid in a feeding vessel and a method of manufacturing the same. The device includes a catheter assembly capable of insertion to a selected blood vessel in the vascular system of a patient. The assembly includes an elongated catheter body, a heat transfer element located at a distal portion of the catheter body and including an interior, an elongated supply lumen adapted to deliver a working fluid to the interior of the heat transfer element and having a hydraulic diameter, an elongated return lumen adapted to return a working fluid from the interior of the heat transfer element and having a hydraulic diameter, and wherein the ratio of the hydraulic diameter of the return lumen to the hydraulic diameter of the supply lumen is substantially equal to 0.75. The method of manufacturing the catheter assembly involves extruding an elongated catheter body; locating a heat transfer element including an interior at a distal portion of the catheter body; extruding an integrated elongated bi-lumen member including a first lumen adapted to receive a guide wire and a second lumen having a hydraulic diameter, the second lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element; and providing the integrated bi-lumen member substantially within the elongated catheter body so that a third lumen having a hydraulic diameter is formed, the third lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element and the ratio of the second lumen hydraulic diameter to the third lumen hydraulic diameter is substantially equal to 0.75.

公开(公告)号：US06475231B2

公开(公告)日：2002-11-05

申请号：US09755919

申请日：2001-01-05

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/126

摘要： The invention provides a method and device for selectively controlling the temperature of a selected organ of a patient for performance of a specified application. The method includes introducing a guide catheter into a blood vessel. The guide catheter may have a soft tip and a retaining flange, and may be used to provide treatments such as administration of thrombolytic drug therapies, stenting procedures, angiographic procedures, etc. A supply tube is provided having a heat transfer element attached to a distal end thereof. The heat transfer element having a plurality of exterior surface irregularities, these surface irregularities having a depth greater than the boundary layer thickness of flow in the feeding artery of the selected organ. The supply tube and heat transfer element may be inserted through the guide catheter to place the heat transfer element in the feeding artery of the selected organ. Turbulence is created around the surface irregularities at a distance from the heat transfer element greater than the boundary layer thickness of flow in the feeding artery, thereby creating turbulence throughout the blood flow in the feeding artery. A working fluid is circulated into the heat transfer element via the supply tube and via an internal lumen of the heat transfer element. The fluid may be circulated out of the heat transfer element via an external lumen of the heat transfer element and through the guide catheter. Heat is thereby transferred between the heat transfer element and the blood in the feeding artery to selectively control the temperature of the selected organ during or soon before or after the specified application.

摘要翻译： 本发明提供一种用于选择性地控制患者的选定器官的温度以执行特定应用的方法和装置。 该方法包括将引导导管引入血管。 引导导管可以具有柔软的尖端和保持凸缘，并且可以用于提供诸如溶栓药物治疗的施用，支架植入程序，血管造影术等的治疗。提供了一种供应管，其具有附接到远端的传热元件 结束。 所述传热元件具有多个外表面凹凸，这些表面凹凸具有大于所选器官的供给动脉中的流动的边界层厚度的深度。 供应管和传热元件可以通过引导导管插入，以将传热元件放置在所选器官的进食动脉中。 在距离传热元件一定距离的表面不规则处产生湍流大于供给动脉中的流动的边界层厚度，从而在进食动脉中的整个血流中产生湍流。 工作流体经由供给管和传热元件的内腔循环到传热元件中。 流体可以经由传热元件的外腔并通过引导导管从传热元件循环出来。 因此，热量在传送元件和供给动脉中的血液之间转移，以在特定应用之前或之后选择性地控制所选器官的温度。

公开(公告)号：US06905509B2

公开(公告)日：2005-06-14

申请号：US09908642

申请日：2001-07-18

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61B17/00 ,  A61B18/02 ,  A61F7/00 ,  A61F7/12 ,  G05D23/22 ,  G05D23/24

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126 ,  G05D23/1919 ,  G05D23/22 ,  G05D23/24

摘要： A catheter and method are provided for modifying a temperature of a patient. The catheter includes a heat transfer element (“HTE”) having surface irregularities shaped to create turbulence in a surrounding fluid. The catheter also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element and a return catheter to return a working fluid from the HTE. A guidewire lumen is provided to receive a guidewire. The guidewire may have a temperature-monitoring device disposed at its distal tip from which feedback may be provided to control the temperature of a source of the working fluid.

摘要翻译： 提供导管和方法来改变患者的温度。 导管包括具有形状以在周围流体中产生湍流的表面凹凸的传热元件（“HTE”）。 导管还包括供给导管，用于将工作流体输送到传热元件的内部，以及返回导管以使来自HTE的工作流体返回。 提供导丝管腔以接收导丝。 导线可以具有设置在其远侧尖端处的温度监视装置，从该尖端可以提供反馈以控制工作流体源的温度。

公开(公告)号：US06478812B2

公开(公告)日：2002-11-12

申请号：US09755834

申请日：2001-01-05

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/126

摘要： The invention provides a method and device for selectively controlling the temperature of a selected organ of a patient for performance of a specified application. The method includes introducing a guide catheter into a blood vessel. The guide catheter may have a soft tip and a retaining flange, and may be used to provide treatments such as administration of thrombolytic drug therapies, stenting procedures, angiographic procedures, etc. A supply tube is provided having a heat transfer element attached to a distal end thereof. The heat transfer element having a plurality of exterior surface irregularities, these surface irregularities having a depth greater than the boundary layer thickness of flow in the feeding artery of the selected organ. The supply tube and heat transfer element may be inserted through the guide catheter to place the heat transfer element in the feeding artery of the selected organ. Turbulence is created around the surface irregularities at a distance from the heat transfer element greater than the boundary layer thickness of flow in the feeding artery, thereby creating turbulence throughout the blood flow in the feeding artery. A working fluid is circulated into the heat transfer element via the supply tube and via an internal lumen of the heat transfer element. The fluid may be circulated out of the heat transfer element via an external lumen of the heat transfer element and through the guide catheter. Heat is thereby transferred between the heat transfer element, and the blood in the feeding artery to selectively control the temperature of the selected organ during or soon before or after the specified application.

摘要翻译： 本发明提供一种用于选择性地控制患者的选定器官的温度以执行特定应用的方法和装置。 该方法包括将引导导管引入血管。 引导导管可以具有柔软的尖端和保持凸缘，并且可以用于提供诸如溶栓药物治疗的施用，支架植入程序，血管造影术等的治疗。提供了一种供应管，其具有附接到远端的传热元件 结束。 所述传热元件具有多个外表面凹凸，这些表面凹凸具有大于所选器官的供给动脉中的流动的边界层厚度的深度。 供应管和传热元件可以通过引导导管插入，以将传热元件放置在所选器官的进食动脉中。 在距离传热元件一定距离的表面不规则处产生湍流大于供给动脉中的流动的边界层厚度，从而在进食动脉中的整个血流中产生湍流。 工作流体经由供给管和传热元件的内腔循环到传热元件中。 流体可以经由传热元件的外腔并通过引导导管从传热元件循环出来。 因此，热量在传热元件和供给动脉中的血液之间转移，以在特定应用之前或之后选择性地控制所选择的器官的温度。

公开(公告)号：US06312452B1

公开(公告)日：2001-11-06

申请号：US09262805

申请日：1999-03-04

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F700

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126 ,  G05D23/1919 ,  G05D23/22 ,  G05D23/24

摘要： A guidable catheter for heating or cooling a surrounding fluid in a feeding vessel in a vasculature of a patient. The catheter includes a heat transfer element, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid. The surface irregularities have a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The catheter assembly also includes a supply catheter having a portion disposed within the heat transfer element to deliver a working fluid to an interior of the heat transfer element. The catheter assembly further includes a return catheter to return a working fluid from the interior of the heat transfer element. A guidewire tube is provided adjacent one of the supply catheter or the return catheter and runs substantially parallel to the axis of the guidable catheter to receive a guidewire disposed within the guidewire tube. The guidable catheter may further have a temperature-monitoring device disposed at the distal tip of the guidewire. The temperature-monitoring device may be a thermocouple or a thermistor. Feedback may further be provided to control the temperature of a source of working fluid. A method is also provided for selectively controlling the temperature of a selected volume of blood in a patient. The method includes introducing a guidewire into a blood vessel feeding a selected volume of blood in a patient and introducing a catheter assembly into the blood vessel feeding a selected volume of blood in a patient by inserting the guidewire into a guidewire tube in the catheter assembly. A working fluid is delivered from a source of working fluid through a supply catheter in the catheter assembly and returned through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. The temperature is monitored of the volume of blood in the feeding vessel by measuring the temperature with a temperature-monitoring device disposed at or near the distal tip of the guidewire.

公开(公告)号：US06251130B1

公开(公告)日：2001-06-26

申请号：US09215040

申请日：1998-12-16

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/126

摘要： The invention provides a method and device for selectively controlling the temperature of a selected organ of a patient for performance of a specified application. The method includes introducing a guide catheter into a blood vessel. The guide catheter may have a soft tip and a retaining flange, and may be used to provide treatments such as administration of thrombolytic drug therapies, stenting procedures, angiographic procedures, etc. A supply tube is provided having a heat transfer element attached to a distal end thereof. The heat transfer element having a plurality of exterior surface irregularities, these surface irregularities having a depth greater than the boundary layer thickness of flow in the feeding artery of the selected organ. The supply tube and heat transfer element may be inserted through the guide catheter to place the heat transfer element in the feeding artery of the selected organ. Turbulence is created around the surface irregularities at a distance from the heat transfer element greater than the boundary layer thickness of flow in the feeding artery, thereby creating turbulence throughout the blood flow in the feeding artery. A working fluid is circulated into the heat transfer element via the supply tube and via an internal lumen of the heat transfer element. The fluid may be circulated out of the heat transfer element via an external lumen of the heat transfer element and through the guide catheter. Heat is thereby transferred between the heat transfer element and the blood in the feeding artery to selectively control the temperature of the selected organ during or soon before or after the specified application.

摘要翻译： 本发明提供一种用于选择性地控制患者的选定器官的温度以执行特定应用的方法和装置。 该方法包括将引导导管引入血管。 引导导管可以具有柔软的尖端和保持凸缘，并且可以用于提供诸如溶栓药物治疗的施用，支架植入程序，血管造影术等的治疗。提供了一种供应管，其具有附接到远端的传热元件 结束。 所述传热元件具有多个外表面凹凸，这些表面凹凸具有大于所选器官的供给动脉中的流动的边界层厚度的深度。 供应管和传热元件可以通过引导导管插入，以将传热元件放置在所选器官的进食动脉中。 在距离传热元件一定距离的表面不规则处产生湍流大于供给动脉中的流动的边界层厚度，从而在进食动脉中的整个血流中产生湍流。 工作流体经由供给管和传热元件的内腔循环到传热元件中。 流体可以经由传热元件的外腔并通过引导导管从传热元件循环出来。 因此，热量在传送元件和供给动脉中的血液之间转移，以在特定应用之前或之后选择性地控制所选器官的温度。

公开(公告)号：US07294142B2

公开(公告)日：2007-11-13

申请号：US10218432

申请日：2002-08-13

申请人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

发明人： John D. Dobak, III ,  Juan C. Lasheras ,  Randell L. Werneth

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126 ,  G05D23/1919 ,  G05D23/22 ,  G05D23/24

摘要： A catheter and method for heating or cooling a surrounding fluid in a feeding vessel in a vasculature of a patient. The catheter includes a heat transfer element shaped and arranged to create turbulence in a surrounding fluid. A guidewire tube runs substantially parallel to the axis of the catheter to receive a guidewire. The catheter may further have a temperature-monitoring device disposed at the distal tip of the guidewire. Feedback may further be provided to control the temperature of a source of working fluid. A method is also provided for selectively controlling the temperature of a selected volume of blood in a patient.

摘要翻译： 一种用于加热或冷却患者脉管系统中的进料容器中的周围流体的导管和方法。 导管包括形状和布置成在周围流体中产生湍流的传热元件。 导丝管基本上平行于导管的轴线运行以接收导丝。 导管还可以具有设置在导丝的远端的温度监测装置。 可进一步提供反馈以控制工作流体源的温度。 还提供了一种用于选择性地控制患者体内选定体积血液的温度的方法。