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    ELECTRIC MODULATION OF SYMPATHETIC NERVOUS SYSTEM
    1.
    发明申请
    ELECTRIC MODULATION OF SYMPATHETIC NERVOUS SYSTEM 有权

    公开(公告)号：US20110319969A1

    公开(公告)日：2011-12-29

    申请号：US13230525

    申请日：2011-09-12

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36085 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36071

    摘要： A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.

    Medical procedure
    2.
    发明授权
    Medical procedure 有权
    医疗程序

    公开(公告)号：US07951183B2

    公开(公告)日：2011-05-31

    申请号：US12152160

    申请日：2008-05-13

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61F7/12

    CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0288 ,  A61F2007/126

    摘要： The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35° C., more preferably 32±2° C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37° C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35° C. using the heat transfer element.

    摘要翻译： 使用血管内冷却元件诱导与医疗过程相关的体温过低。 根据本发明的第一方面，进行冠状动脉旁路手术，其中患者的血液与患者的肺充氧，并且使用患者的心脏或使用体内泵循环血液。 该方法优选包括：（a）将热传递元件定位在患者的血管中; （b）使用传热元件将患者的身体冷却至小于35℃，更优选32±2℃; 和（c）在动脉血液供应和冠状动脉之间形成流体连通的移植物。 优选在形成流体连通移植物的步骤之后，使用传热元件将患者的身体加热至约37℃。 根据本发明的另一方面，在患者处于有意识或半自觉状态时提供低温医疗程序，其包括（a）向患者施用β-阻断药物; （b）将传热元件输送到患者的血管; 和（c）使用传热元件将患者或患者体内的区域冷却至小于35℃。

    DEVICES AND METHODS FOR ACCELEROMETER-BASED CHARACTERIZATION OF CARDIAC FUNCTION AND IDENTIFICATION OF LV TARGET PACING ZONES
    3.
    发明申请
    DEVICES AND METHODS FOR ACCELEROMETER-BASED CHARACTERIZATION OF CARDIAC FUNCTION AND IDENTIFICATION OF LV TARGET PACING ZONES 失效
    用于基于加速度计的心脏功能特征和LV目标区域识别的装置和方法

    公开(公告)号：US20100049063A1

    公开(公告)日：2010-02-25

    申请号：US12396420

    申请日：2009-03-02

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61B5/02

    CPC分类号： A61B5/02 ,  A61B5/0456 ,  A61B2562/0219 ,  A61B2562/028 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/36585 ,  A61N2001/0585

    摘要： Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and uses this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non-implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system (“IAD”) includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG.

    摘要翻译： 根据本发明的系统采用加速度传感器来表征位移和振动LV运动，并且使用该运动数据来表征用于分析LV功能的LV循环的不同相位。 系统可以使用加速度传感器来识别LV或RV中的目标起搏区域或区域，通过将相对于QRS的运动迟发性区域，或等容性收缩或二尖瓣闭合定位，或通过起搏区域和测量LV功能来定位 响应起搏。 系统还提供用于测量LV运动和表征LV功能的可植入或不可植入的加速度传感器装置。 可植入心肌加速度感测系统（“IAD”）包括至少一个加速度传感器，数据采集和处理装置以及电磁（例如RF）通信装置。 IAD可以集成到CRT设备的起搏引线中，并且可独立于CRT IPG进行操作。

    METHOD AND DEVICE FOR LIPOSUCTION
    4.
    发明申请
    METHOD AND DEVICE FOR LIPOSUCTION 审中-公开
    用于排泄的方法和装置

    公开(公告)号：US20090318899A1

    公开(公告)日：2009-12-24

    申请号：US12338941

    申请日：2008-12-18

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61M1/00

    CPC分类号： A61M1/0084 ,  A61B17/3203 ,  A61M1/0058 ,  A61M2202/08

    摘要： Systems and methods for liposuction are disclosed that use a lipid-emulsifying fluid to produce fluid jet disruption and Venturi pumping of fat tissue. The device includes a flexible or rigid probe with an inlet lumen and an outlet lumen. The inlet lumen is in fluid communication with a pump capable of producing high pressures, e.g., 250-3500 psi. The pump is in fluid communication with a volume of a liquid such as sterile saline that may or may not contain a fat emulsifier. At the end of the inlet lumen is a conical constriction or a port that accelerates the emulsification fluid to high velocities. The high velocity jet stream creates a low pressure area that draws the fat tissue into proximity with the jet stream. The jet stream directly and through turbulent vortices breaks up the fat cells. The lipid of the fat cells is subsequently emulsified by the emulsification fluid.

    摘要翻译： 公开了用于吸脂的系统和方法，其使用脂质 - 乳化液来产生流体喷射干扰和文丘里泵送脂肪组织。 该装置包括具有入口腔和出口腔的柔性或刚性探针。 入口腔与能够产生高压（例如250-3500psi）的泵流体连通。 泵与一定体积的液体流体连通，例如无菌盐水，其可以含有或不含有脂肪乳化剂。 在入口管腔的末端是锥形收缩或将乳化液加速到高速度的端口。 高速喷射流产生低压区域，其将脂肪组织吸引到喷射流附近。 喷射流直接和通过湍流涡流分解脂肪细胞。 脂肪细胞的脂质随后被乳化液乳化。

    Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
    5.
    发明申请
    Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
    用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动

    公开(公告)号：US20080300585A1

    公开(公告)日：2008-12-04

    申请号：US11978888

    申请日：2007-10-30

    申请人： John D. Dobak, III ,  Hans W. Kramer ,  Steven A. Yon

    发明人： John D. Dobak, III ,  Hans W. Kramer ,  Steven A. Yon

    IPC分类号： A61B18/02

    CPC分类号： A61F7/12 ,  A61B18/02 ,  A61B2017/22002 ,  A61B2017/22054 ,  A61B2018/00023 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/126

    摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.

    摘要翻译： 本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。 本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。 可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。 诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。 导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。