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1.Expression vectors for stimulating an immune response and methods of using the same 有权
标题翻译: 用于刺激免疫应答的表达载体及其使用方法公开(公告)号:US06534482B1
公开(公告)日:2003-03-18
申请号:US09311784
申请日:1999-05-13
申请人: John D. Fikes , Gary G. Hermanson , Alessandro Sette , Glenn Y. Ishioka , Brian Livingston , Robert W. Chesnut
发明人: John D. Fikes , Gary G. Hermanson , Alessandro Sette , Glenn Y. Ishioka , Brian Livingston , Robert W. Chesnut
IPC分类号: A61K4800
CPC分类号: C07K14/70539 , A01K2217/05 , A61K38/00 , A61K39/385 , A61K2039/605 , C07K14/005 , C07K14/445 , C07K2319/00 , C07K2319/02 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要: The present invention relates to nucleic acid vaccines encoding multiple CTL and HTL epitopes and MHC targeting sequences.
摘要翻译: 本发明涉及编码多种CTL和HTL表位和MHC靶向序列的核酸疫苗。
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公开(公告)号:US08007810B2
公开(公告)日:2011-08-30
申请号:US12710836
申请日:2010-02-23
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US09394350B2
公开(公告)日:2016-07-19
申请号:US14081086
申请日:2013-11-15
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20120183598A1
公开(公告)日:2012-07-19
申请号:US13212847
申请日:2011-08-18
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20100209493A1
公开(公告)日:2010-08-19
申请号:US12710836
申请日:2010-02-23
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epi tope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或来自CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20080274129A1
公开(公告)日:2008-11-06
申请号:US10553703
申请日:2004-04-16
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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7.HLA CLASS I A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND VACCINE COMPOSITIONS 审中-公开
标题翻译: HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号:US20140147490A1
公开(公告)日:2014-05-29
申请号:US13662906
申请日:2012-10-29
申请人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
IPC分类号: A61K39/00
CPC分类号: A61K39/0011 , A61K2039/55516
摘要: A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译: 一种组合物或疫苗组合物,其包含至少一种具有小于600个连续氨基酸的肽,其具有与CEA,HER2 / neu,MAGE2,MAGE3或p53的天然序列具有100%同一性,所述肽还包含至少一个选自 表6。
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8.HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开
标题翻译: HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号:US20080279924A1
公开(公告)日:2008-11-13
申请号:US11976908
申请日:2007-10-29
申请人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
CPC分类号: A61K9/0019 , A61K9/127 , A61K38/08
摘要: A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译: 一种组合物或疫苗组合物,其包含至少一种具有小于600个连续氨基酸的肽,其具有与CEA,HER2 / neu,MAGE2,MAGE3或p53的天然序列具有100%同一性,所述肽还包含至少一个选自 表6。
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公开(公告)号:US20090169574A1
公开(公告)日:2009-07-02
申请号:US11978730
申请日:2007-10-30
申请人: Shabnam Tangri , Alessandro Sette , Glenn Ishioka , John D. Fikes
发明人: Shabnam Tangri , Alessandro Sette , Glenn Ishioka , John D. Fikes
CPC分类号: C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/555 , C07K7/06 , C07K7/08 , C07K14/70503 , C07K14/70539 , C07K14/71 , C07K2319/00
摘要: Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wildtype epitopes.
摘要翻译: 通过在这些表位的位置3和/或5和/或7处提供保守或半保守氨基酸取代来制备I类表位的异位类似物。 类似物可用于相对于相应的野生型表位引起免疫应答。
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10.HLA CLASS I A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND VACCINE COMPOSITIONS 审中-公开
标题翻译: HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号:US20110318408A1
公开(公告)日:2011-12-29
申请号:US13155307
申请日:2011-06-07
申请人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人: John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
IPC分类号: A61K9/127 , C07K7/08 , C07K14/00 , A61K39/00 , C12N5/0784
CPC分类号: A61K9/0019 , A61K9/127 , A61K38/08
摘要: A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译: 一种组合物或疫苗组合物,其包含至少一种具有小于600个连续氨基酸的肽,其具有与CEA,HER2 / neu,MAGE2,MAGE3或p53的天然序列具有100%同一性,所述肽还包含至少一个选自 表6。
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