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公开(公告)号:US08007810B2
公开(公告)日:2011-08-30
申请号:US12710836
申请日:2010-02-23
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20120183598A1
公开(公告)日:2012-07-19
申请号:US13212847
申请日:2011-08-18
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20100209493A1
公开(公告)日:2010-08-19
申请号:US12710836
申请日:2010-02-23
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epi tope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或来自CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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公开(公告)号:US20080274129A1
公开(公告)日:2008-11-06
申请号:US10553703
申请日:2004-04-16
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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5.Expression vectors for stimulating an immune response and methods of using the same 有权
标题翻译: 用于刺激免疫应答的表达载体及其使用方法公开(公告)号:US06534482B1
公开(公告)日:2003-03-18
申请号:US09311784
申请日:1999-05-13
申请人: John D. Fikes , Gary G. Hermanson , Alessandro Sette , Glenn Y. Ishioka , Brian Livingston , Robert W. Chesnut
发明人: John D. Fikes , Gary G. Hermanson , Alessandro Sette , Glenn Y. Ishioka , Brian Livingston , Robert W. Chesnut
IPC分类号: A61K4800
CPC分类号: C07K14/70539 , A01K2217/05 , A61K38/00 , A61K39/385 , A61K2039/605 , C07K14/005 , C07K14/445 , C07K2319/00 , C07K2319/02 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要: The present invention relates to nucleic acid vaccines encoding multiple CTL and HTL epitopes and MHC targeting sequences.
摘要翻译: 本发明涉及编码多种CTL和HTL表位和MHC靶向序列的核酸疫苗。
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公开(公告)号:US09394350B2
公开(公告)日:2016-07-19
申请号:US14081086
申请日:2013-11-15
CPC分类号: A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/47
摘要: A peptide or composition comprising at least one HLA-A2 epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
摘要翻译: 包含至少一种HLA-A2表位或CEA,HER2 / neu,MAGE2,MAGE3或p53的类似物的肽或组合物。
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7.Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 失效
标题翻译: 使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号:US06689363B1
公开(公告)日:2004-02-10
申请号:US09239043
申请日:1999-01-27
申请人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
IPC分类号: A61K3800
CPC分类号: C07K7/06 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/705 , C07K14/70539 , C07K14/82 , C12N2730/10122 , C12N2740/16022 , C12N2760/16122 , C12N2770/24222
摘要: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译: 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说,本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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8.Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开
标题翻译: 使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号:US20090311283A1
公开(公告)日:2009-12-17
申请号:US11976998
申请日:2007-10-30
申请人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号: C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译: 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说,本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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9.Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开
标题翻译: 使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号:US20110097352A9
公开(公告)日:2011-04-28
申请号:US11976998
申请日:2007-10-30
申请人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人: Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号: C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译: 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说,本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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10.PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS 审中-公开
标题翻译: 用于诱导针对HEPATITIS C病毒的CTL和/或HTL反应的肽公开(公告)号:US20100099613A1
公开(公告)日:2010-04-22
申请号:US12574214
申请日:2009-10-06
申请人: Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert W. Chesnut , Mark Newman , Alessandra Sette , John Sidney , Scott Southwood
发明人: Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert W. Chesnut , Mark Newman , Alessandra Sette , John Sidney , Scott Southwood
IPC分类号: A61K38/16 , A61K31/7052 , A61P37/00 , A61K38/10 , A61K38/08
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要: The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译: 本发明涉及衍生自丙型肝炎病毒(HCV)的肽和编码它们的核酸。 肽是在宿主中引起CTL和/或HTL应答的肽。 本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。
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