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公开(公告)号：US20120245475A1
公开(公告)日：2012-09-27
申请号：US13479967
申请日：2012-05-24
IPC分类号： A61B5/0205
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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公开(公告)号：US08905938B2
公开(公告)日：2014-12-09
申请号：US13479967
申请日：2012-05-24
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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公开(公告)号：US08204585B2
公开(公告)日：2012-06-19
申请号：US11312278
申请日：2005-12-20
IPC分类号： A61B5/05
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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4.发明授权Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance 有权使用胸部直流阻抗校正阻抗监测呼吸体积公开(公告)号：US08200326B2
公开(公告)日：2012-06-12
申请号：US12557372
申请日：2009-09-10
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译： 一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。 控制器耦合到跨胸阻抗电路。 控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子 胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。
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公开(公告)号：US08831716B2
公开(公告)日：2014-09-09
申请号：US11853590
申请日：2007-09-11
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译： 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。
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公开(公告)号：US20090069708A1
公开(公告)日：2009-03-12
申请号：US11853590
申请日：2007-09-11
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译： 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。
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7.发明申请公开(公告)号：US20110218450A1
公开(公告)日：2011-09-08
申请号：US12715503
申请日：2010-03-02
IPC分类号： A61B5/085
摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
摘要翻译： 吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。 直接测试对象呼吸测量可能仅作为示例，阻抗测量。 直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。 由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。 此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。
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公开(公告)号：US20090326408A1
公开(公告)日：2009-12-31
申请号：US12165430
申请日：2008-06-30
申请人： Loell Boyce Moon
发明人： Loell Boyce Moon
IPC分类号： A61B5/053
CPC分类号： A61B5/0809 , A61B5/0538 , A61B2503/40
摘要： A method of measuring lung impedance of a subject can include positioning current-injection electrodes on or within the subject in a configuration such that a current injected between the current-injection electrodes propagates substantially through a first lung of the subject, and not through a heart and a second lung of the subject; positioning voltage-measurement electrodes on or within the subject in a configuration such that voltage measuring fields propagate substantially through the first lung and the second lung of the subject, but not through the heart of the subject; and injecting a current between the current-injection electrodes, as positioned, and measuring a resulting voltage between the voltage-measurement electrodes, as positioned, to obtain an impedance measure across lung tissue. The method can further include injecting current and measuring the resulting voltage multiple times over a time period to monitor respiration of the subject over the time period.
摘要翻译： 测量受试者的肺阻抗的方法可以包括在被配置中或内部定位电流注入电极，使得注入电流注入电极之间的电流基本上传播通过受试者的第一肺而不通过心脏 和受试者的第二肺; 将电压测量电极定位在受试者内部或内部，使得电压测量场基本上通过受试者的第一肺和第二肺传播，但不通过受试者的心脏; 并且在定位的电流注入电极之间注入电流，并测量定位的电压测量电极之间的所得电压，以获得横跨肺组织的阻抗测量值。 该方法还可以包括在一段时间内多次注入电流并测量所得到的电压，以监测受试者在该时间段内的呼吸。
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公开(公告)号：US07848811B2
公开(公告)日：2010-12-07
申请号：US11314170
申请日：2005-12-21
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/1116 , A61N1/36535 , A61N1/36542
摘要： A system and method determines the posture of a body. The system is first calibrated by attaching it to, or implanted it into, a body, placing the body in particular postures, and generating spectral signatures for each of those postures. Thereafter, the system generates spectral signatures for particular instants in time, correlates these instant signatures with the stored signatures, from which the posture of the body at that instant in time is determined.
摘要翻译： 系统和方法确定身体的姿势。 该系统首先通过将身体附着或植入体内进行校准，将身体放置在特定姿势中，并为每个姿势产生光谱特征。 此后，系统及时地为特定时刻生成频谱特征，将这些即时签名与所存储的签名相关联，从而确定在该时刻的身体姿势。
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公开(公告)号：US20120029372A1
公开(公告)日：2012-02-02
申请号：US13271717
申请日：2011-10-12
申请人： Paul A. Haefner , Loell Boyce Moon
发明人： Paul A. Haefner , Loell Boyce Moon
IPC分类号： A61B5/0452 , A61M5/168 , A61B5/02
CPC分类号： A61M37/00 , A61B5/021 , A61B5/0402 , A61B5/4839
摘要： Drug delivery methods and systems that include a determination of whether a cardiac condition is normal or abnormal, so that a drug may be administered in accordance with that determination. In one implementation, a drug delivery device may be controlled to reduce or stop the drug administration when a normal cardiac condition is detected. In another implementation, a patient monitoring device determines the duration that a cardiac condition is normal and provides an output indicative of the determination so that the patient may alter a therapy accordingly.
摘要翻译： 包括确定心脏病状是正常还是异常的药物递送方法和系统，以便可以根据该测定来施用药物。 在一个实施方案中，当检测到正常心脏病状时，可以控制药物递送装置以减少或停止药物施用。 在另一实现中，患者监视装置确定心脏状况正常的持续时间，并提供指示确定的输出，使得患者可以相应地改变治疗。
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