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公开(公告)号：US20120245475A1
公开(公告)日：2012-09-27
申请号：US13479967
申请日：2012-05-24
IPC分类号： A61B5/0205
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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公开(公告)号：US08905938B2
公开(公告)日：2014-12-09
申请号：US13479967
申请日：2012-05-24
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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公开(公告)号：US08204585B2
公开(公告)日：2012-06-19
申请号：US11312278
申请日：2005-12-20
IPC分类号： A61B5/05
CPC分类号： A61B5/0535 , A61B5/0809 , A61B5/7207 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
摘要翻译： 实施了可植入的医疗设备和技术，其使用生物阻抗来测量患者生理学的方面。 信号分离方法至少部分地在可植入装置中进行。 该方法包括使用耦合到可植入装置的多个可植入电极来检测多个阻抗信号。 该方法还包括使用诸如基于算法的分离技术之类的信号分离技术来分离来自多个阻抗信号的一个或多个信号。
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4.发明授权Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance 有权使用胸部直流阻抗校正阻抗监测呼吸体积公开(公告)号：US08200326B2
公开(公告)日：2012-06-12
申请号：US12557372
申请日：2009-09-10
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译： 一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。 控制器耦合到跨胸阻抗电路。 控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子 胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。
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公开(公告)号：US08831716B2
公开(公告)日：2014-09-09
申请号：US11853590
申请日：2007-09-11
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译： 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。
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公开(公告)号：US20090069708A1
公开(公告)日：2009-03-12
申请号：US11853590
申请日：2007-09-11
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译： 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。
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7.发明申请Rapid Shallow Breathing Detection for use in Congestive Heart Failure Status Determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US20100298732A1
公开(公告)日：2010-11-25
申请号：US12847645
申请日：2010-07-30
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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8.发明授权Rapid shallow breathing detection for use in congestive heart failure status determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US07775983B2
公开(公告)日：2010-08-17
申请号：US11229316
申请日：2005-09-16
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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9.发明授权Rapid shallow breathing detection for use in congestive heart failure status determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US07993280B2
公开(公告)日：2011-08-09
申请号：US12847645
申请日：2010-07-30
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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公开(公告)号：US08936556B2
公开(公告)日：2015-01-20
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
IPC分类号： A61B5/02 , G06N5/02 , A61B5/08 , A61B5/00 , A61B5/091 , A61B5/04 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/029 , A61B5/11
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译： 检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。 使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。 基于基线阈值和重新采样的iMV信号之间的比较来检测呼吸紊乱。
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