公开(公告)号：US20080045603A1

公开(公告)日：2008-02-21

申请号：US11826804

申请日：2007-07-18

申请人： John Devane ,  John Kelly ,  Mary Martin

发明人： John Devane ,  John Kelly ,  Mary Martin

IPC分类号： A61K31/135 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P25/00 ,  A61P35/00 ,  A61P9/12

CPC分类号： A61K31/277

摘要： The present invention is directed to methods comprising administering a composition comprising a therapeutically effective amount of (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats, prevents and/or manages at least one condition having MT1 receptor, 5-HT2B receptor and L-type calcium channel activity and releases the (R)-verapamil, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a co-primary activity on the MT1 receptor, the 5-HT2B receptor, and the L-type calcium channel.

摘要翻译： 本发明涉及包括施用包含治疗有效量的（R） - 维拉帕米，其衍生物或其药学上可接受的盐的组合物的组合物，其中所述组合物治疗，预防和/或控制至少一种具有MT1 受体，5-HT2B受体和L-型钙通道活性，并释放（R） - 维拉帕米，其衍生物或其药学上可接受的盐，以在MT1受体上显示共同活性， 2B受体和L型钙通道。

公开(公告)号：US20090023814A1

公开(公告)日：2009-01-22

申请号：US12165836

申请日：2008-07-01

申请人： John Devane ,  John Kelly ,  Mary Martin

发明人： John Devane ,  John Kelly ,  Mary Martin

IPC分类号： A61K31/137 ,  A61P1/00

CPC分类号： A61K31/00 ,  A61K31/277 ,  A61K45/06

摘要： The present invention is directed to compositions and to methods comprising a composition comprising a therapeutically effective amount of a pharmaceutically active agent such as (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats and/or manages at least one condition having MT1 receptor activity and releases the pharmaceutically active agent, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a primary activity on the MT1 receptor such as, exhibiting at least five times more activity on the MT1 receptor compared with the MT2 receptor.

摘要翻译： 本发明涉及组合物和方法，其包含包含治疗有效量的药物活性剂如（R） - 维拉帕米，其衍生物或其药学上可接受的盐的组合物，其中所述组合物治疗和/或管理 至少一种具有MT1受体活性的病症，并且释放其药物活性剂，其衍生物或其药学上可接受的盐，以在MT1受体上显示出主要活性，例如与MT1受体相比表现出至少五倍的活性 MT2受体。

公开(公告)号：US06849661B2

公开(公告)日：2005-02-01

申请号：US10294692

申请日：2002-11-15

申请人： John Kelly ,  John Devane ,  Ted G. Dinan ,  P.W. Napoleon Keeling

发明人： John Kelly ,  John Devane ,  Ted G. Dinan ,  P.W. Napoleon Keeling

IPC分类号： A61K31/277 ,  A61P1/06 ,  A61K31/275

CPC分类号： A61K31/277

摘要： The present invention is directed to methods of treating, preventing, and/or managing abnormal increases in gastrointestinal motility, and intestinal conditions that cause the same. Such conditions include, but are not limited to, irritable bowel syndrome (IBS), infectious diseases of the small and large intestines, and symptoms of any of the foregoing. In particular, the present invention discloses methods of using enriched (R)-verapamil, as well as compositions and formulations containing the same.

摘要翻译： 本发明涉及治疗，预防和/或控制胃肠蠕动异常升高和导致其的肠道病症的方法。 这些病症包括但不限于肠易激综合征（IBS），小肠和大肠的感染性疾病以及任何上述症状。 特别地，本发明公开了使用富集的（R） - 维拉帕米以及含有它们的组合物和制剂的方法。

公开(公告)号：US09124530B2

公开(公告)日：2015-09-01

申请号：US13883536

申请日：2011-11-03

申请人： Anthony Peyton ,  John Kelly

发明人： Anthony Peyton ,  John Kelly

IPC分类号： H04L12/26 ,  H04Q1/02

CPC分类号： H04L43/50 ,  H04Q1/136

摘要： An apparatus for identifying interconnections in a network. The apparatus comprises a plurality of transmitter coupling units, a plurality of receiver coupling units, and an interconnection identification means configured to identify interconnections between the transmitter coupling units and the receiver coupling units by cable lines in the network. In some embodiments, the interconnection identification means is configured to, if any one of the transmitter coupling units is coupled to the same cable line as a selected one of the receiver coupling units, identify the interconnection between the transmitter coupling unit and the selected receiver coupling unit according to by a binary tree search algorithm.

摘要翻译： 一种用于识别网络中的互连的装置。 该装置包括多个发射器耦合单元，多个接收器耦合单元和配置成通过网络中的电缆线来识别发射器耦合单元和接收器耦合单元之间的互连的互连识别装置。 在一些实施例中，互连识别装置被配置为：如果发射机耦合单元中的任何一个耦合到与接收机耦合单元中所选择的一个相同的电缆线，则识别发射机耦合单元与所选接收机耦合之间的互连 根据二叉树搜索算法的单位。

公开(公告)号：US20130263549A1

公开(公告)日：2013-10-10

申请号：US13804735

申请日：2013-03-14

申请人： John Kelly

发明人： John Kelly

IPC分类号： E04G21/32

CPC分类号： E04G21/3233 ,  E04G21/3247

摘要： A system for providing a safety barrier around a work area on a high-rise structure includes at least one vertical rail detachably connected to the structure. The system also includes a safety screen assembly detachably connected to the structure. The system further includes an adjustment mechanism operable to translate the vertical rail(s) and safety screen assembly relative to the structure at appropriate times. A method for moving a safety screen system on a high-rise structure includes detachably coupling at least one vertical rail and safety screen assembly to the structure, and actuating an adjustment mechanism at appropriate times to move the rail(s) and safety screen system upwardly relative to the structure.

摘要翻译： 用于在高层结构上围绕工作区域提供安全屏障的系统包括可拆卸地连接到结构的至少一个垂直导轨。 该系统还包括可拆卸地连接到该结构的安全屏组件。 该系统还包括调节机构，其可操作以在适当的时间相对于该结构平移垂直导轨和安全屏幕组件。 用于在高层结构上移动安全屏幕系统的方法包括将至少一个垂直导轨和安全屏幕组件可拆卸地联接到结构上，并且在适当的时间致动调节机构以使轨道和安全屏幕系统向上移动 相对于结构。

公开(公告)号：US08397058B1

公开(公告)日：2013-03-12

申请号：US09628315

申请日：2000-07-28

申请人： Kazuo J. Ezawa ,  Dave Roberts ,  Michael Foster ,  John Kelly

发明人： Kazuo J. Ezawa ,  Dave Roberts ,  Michael Foster ,  John Kelly

IPC分类号： H04L29/06 ,  H04L9/32 ,  H04L9/00 ,  G06F12/14 ,  G06F7/04

CPC分类号： G07F7/1008 ,  G06Q20/341 ,  G06Q20/4097 ,  G06Q20/40975 ,  G07F7/082

摘要： A method and system which provides communication between a first portable device and a second portable device. The first portable device stores a first sequence number and a first key, and the second portable device stores a second sequence number and a second key. Verification is performed using the first and second keys. The first sequence number is compared to the second sequence number. If the second sequence number is newer than the first sequence number, the first sequence number is set to have a value of the second sequence number if the verification succeeds. If the first sequence number is newer than the second sequence number, the second sequence number is set to have a value of the first sequence number if verification succeeds.

摘要翻译： 一种在第一便携式设备和第二便携式设备之间提供通信的方法和系统。 第一便携式设备存储第一序列号和第一密钥，并且第二便携式设备存储第二序列号和第二密钥。 使用第一和第二键执行验证。 将第一序列号与第二序列号进行比较。 如果第二序列号比第一序列号新，则如果验证成功，则将第一序列号设置为具有第二序列号的值。 如果第一序列号比第二序列号更新，则如果验证成功，则将第二序列号设置为具有第一序列号的值。

公开(公告)号：US20120271339A1

公开(公告)日：2012-10-25

申请号：US13091319

申请日：2011-04-21

申请人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

发明人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

IPC分类号： A61M29/02

CPC分类号： A61M25/104 ,  A61M2205/3306 ,  G01L1/246

摘要： An apparatus and method for determining an expanded diameter of a catheter balloon. An optical sensor includes an elongated optical fiber with at least one diffraction grating formed in a core of a distal portion thereof. The fiber distal portion is coupled to the inflatable balloon. Broadband light is transmitted to the diffraction grating by an optical interrogator. A portion of the light is reflected from the diffraction grating and is received by a wavelength detector. The wavelength of the reflected portion of light is dependent on the strain applied to the diffraction grating. The wavelength detector determines the strain in the balloon and correlates the strain to the diameter of the balloon.

摘要翻译： 一种用于确定导管球囊的扩大直径的装置和方法。 光学传感器包括细长光纤，其中至少一个衍射光栅形成在其远端部分的芯中。 纤维远端部分连接到可充气球囊。 宽光束通过光学询问器传输到衍射光栅。 一部分光从衍射光栅反射并被波长检测器接收。 光的反射部分的波长取决于施加到衍射光栅的应变。 波长检测器确定球囊中的应变并将应变与球囊的直径相关联。

公开(公告)号：US20120220705A1

公开(公告)日：2012-08-30

申请号：US13406911

申请日：2012-02-28

申请人： Andrea Hamilton ,  John Kelly

发明人： Andrea Hamilton ,  John Kelly

IPC分类号： C09D133/12 ,  C09D133/08 ,  C08K5/521 ,  C09D133/14

CPC分类号： C09D133/08 ,  C08K5/41 ,  C08K5/521 ,  C08L2201/54 ,  C08L2312/00 ,  C09D133/26

摘要： Environmentally friendly, high performance coating formulations and methods for their preparation are described. The coating formulations can be prepared as aqueous dispersions. The aqueous dispersions include a plurality of multiphase polymer particles and a C8-C18 alkyl alcohol alkoxylated phosphate ester surfactant. The multiphase particles include an acrylic-based copolymer derived from one or more (meth)acrylate monomers and at least one copolymerizable surfactant. Optionally, the acrylic-based copolymer is further derived from one or more acid monomers, one or more amide monomers, and/or one or more molecular weight regulators. Further described herein are products prepared from the aqueous dispersions, such as for high gloss and satin paint compositions, that can have a low VOC content.

摘要翻译： 描述了环保的高性能涂料配方及其制备方法。 涂料制剂可以制备成水分散体。 水分散体包括多个多相聚合物颗粒和C8-C18烷基醇烷氧基化磷酸酯表面活性剂。 多相颗粒包括衍生自一种或多种（甲基）丙烯酸酯单体和至少一种可共聚表面活性剂的丙烯酸类共聚物。 任选地，丙烯酸类共聚物进一步衍生自一种或多种酸单体，一种或多种酰胺单体和/或一种或多种分子量调节剂。 本文进一步描述的是由水分散体制备的产品，例如可以具有低VOC含量的高光泽和缎面涂料组合物。

公开(公告)号：US20120136418A1

公开(公告)日：2012-05-31

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US07569193B2

公开(公告)日：2009-08-04

申请号：US10742126

申请日：2003-12-19

申请人： Shawn Ferron ,  John Kelly ,  Robbert Vermeulen

发明人： Shawn Ferron ,  John Kelly ,  Robbert Vermeulen

IPC分类号： B01D50/00

CPC分类号： B01D53/34 ,  F23G7/061 ,  F23L7/00 ,  F23L2900/07005 ,  F23L2900/07008 ,  F23M5/00 ,  F23M2900/05004 ,  Y02E20/344

摘要： The present invention relates to systems and methods for controlled combustion of gaseous pollutants while reducing and removing deposition of unwanted reaction products from within the treatment systems. The systems employ a two-stage thermal reactor having an upper thermal reactor including at least one inlet for mixing a gaseous waste stream with oxidants and combustible fuels for thermal combustion within the upper thermal reactor. The upper thermal reactor further includes a double wall structure having an outer exterior wall and an interior porous wall that defines an interior space for holding a fluid and ejecting same, in a pulsating mode, through the interior porous wall into the upper thermal reactor to reduce deposition of the reaction products on the interior of the upper reactor chamber. The two-stage thermal reactor further includes a lower reactor chamber for flowing reaction products formed in the upper thermal reactor through a water vortex that provides a water overflow along the interior of the lower reactor chamber thereby reducing deposition of unwanted products on the interior surface of the lower reactor.

摘要翻译： 本发明涉及用于气态污染物的受控燃烧的系统和方法，同时减少和去除处理系统内不需要的反应产物的沉积。 该系统采用两级热反应器，其具有上部热反应器，该上部热反应器包括用于将气态废物流与氧化剂混合的至少一个入口和用于在上部热反应器内进行热燃烧的可燃性燃料。 上部热反应器还包括双壁结构，其具有外部外壁和内部多孔壁，其限定用于保持流体的内部空间并且以脉动模式将其喷射通过内部多孔壁进入上部热反应器以减少 反应产物沉积在上反应器室的内部。 两级热反应器还包括下反应器室，用于通过水涡流流动在上部热反应器中形成的反应产物，该水涡流沿着下反应器室的内部提供水溢流，从而减少不需要的产物在内表面上的沉积 下反应堆。