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1.发明授权Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors 有权使用拓扑异构酶抑制剂治疗炎性疾病的组合物和方法公开(公告)号：US08883856B2
公开(公告)日：2014-11-11
申请号：US10220190
申请日：2001-02-28
申请人： John Jackson , Helen M. Burt , Stephen K. Dordunoo
发明人： John Jackson , Helen M. Burt , Stephen K. Dordunoo
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/122 , A61K31/365 , A61K31/4745 , A61K31/704
摘要： Topoisomerase inhibitors are useful for the treatment of inflammatory disorders including arthritis, restenosis, surgical adhesions and other diseases. Controlled release polymeric formulations to topoisomerase inhibitors are particularly suitable for this use.
摘要翻译： 拓扑异构酶抑制剂可用于治疗炎症性疾病，包括关节炎，再狭窄，手术粘连和其他疾病。 对拓扑异构酶抑制剂的控制释放聚合物制剂特别适用于此用途。
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公开(公告)号：US08221794B2
公开(公告)日：2012-07-17
申请号：US12716854
申请日：2010-03-03
申请人： William L. Hunter , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John J. Jackson , Stephen K. Dordunoo
发明人： William L. Hunter , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John J. Jackson , Stephen K. Dordunoo
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20100292314A1
公开(公告)日：2010-11-18
申请号：US12820572
申请日：2010-06-22
申请人： William L. HUNTER , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
发明人： William L. HUNTER , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20090074830A1
公开(公告)日：2009-03-19
申请号：US11830208
申请日：2007-07-30
申请人： William L. HUNTER , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
发明人： William L. HUNTER , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
IPC分类号： A61F2/00 , A61K9/14 , A61K31/337 , A61K31/519 , A61K31/565 , A61K33/22
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20090036517A1
公开(公告)日：2009-02-05
申请号：US12098173
申请日：2008-04-04
申请人： William L. Hunter , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
发明人： William L. Hunter , Lindsay S. Machan , A. Larry Arsenault , Helen M. Burt , John K. Jackson , Stephen K. Dordunoo
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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公开(公告)号：US20200093750A1
公开(公告)日：2020-03-26
申请号：US16695498
申请日：2019-11-26
IPC分类号： A61K9/28 , A61K31/155
摘要： Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.
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7.发明申请公开(公告)号：US20110294763A1
公开(公告)日：2011-12-01
申请号：US13146572
申请日：2010-01-22
申请人： Stephen K. Dordunoo
发明人： Stephen K. Dordunoo
CPC分类号： A61K31/55 , A61K9/0014 , A61K9/08 , A61K31/155 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/415 , A61K31/416 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/44 , A61K2300/00
摘要： The invention discloses solutions of diclofenac, carbamazepine and benzydamine, at therapeutically desirable concentrations and the solutions stable for extended periods of time at room temperature.
摘要翻译： 本发明公开了治疗期望浓度的双氯芬酸，卡马西平和苯甲胺的溶液，并且溶液在室温下长时间稳定。
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