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1.发明申请Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation 审中-公开新型小分子对人微血管内皮细胞增殖具有选择性细胞毒性公开(公告)号：US20070254894A1
公开(公告)日：2007-11-01
申请号：US11651406
申请日：2007-01-09
申请人： John Kane , Bradford Hirth , Christopher Yee , Mark Staveski , Hans-Peter Biemann , Marko Pregel
发明人： John Kane , Bradford Hirth , Christopher Yee , Mark Staveski , Hans-Peter Biemann , Marko Pregel
IPC分类号： A61K31/4709 , A61K31/497 , A61P9/00 , C07D215/38 , C07D243/08 , C07D401/14 , C07D413/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed herein are angiogenesis inhibitors represented by formula (I) or formula (II): The variables for formulas (I) and (II) are defined herein.
摘要翻译： 本文公开了由式（I）或式（II）表示的血管生成抑制剂：式（I）和（II）的变量在本文中定义。
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2.发明申请Tetrahydroisoquinoline derivatives for treating protein trafficking diseases 有权用于治疗蛋白质运输疾病的四氢异喹啉衍生物公开(公告)号：US20050176761A1
公开(公告)日：2005-08-11
申请号：US11006042
申请日：2004-12-07
申请人： Marko Pregel , Bradford Hirth , John Kane , Shuang Qiao , Jill Gregory , Lisa Cuff
发明人： Marko Pregel , Bradford Hirth , John Kane , Shuang Qiao , Jill Gregory , Lisa Cuff
IPC分类号： A61K31/47 , A61K31/4709
CPC分类号： A61K31/4709 , A61K31/47
摘要： Tetrhydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.
摘要翻译： 本文公开了四氢异喹啉衍生物，包含它们的药物组合物和治疗疾病的方法。 所公开的化合物可用于治疗和预防由氯离子通道活性和/或蛋白质运输介导的疾病，包括但不限于与粘液纤毛清除障碍相关的疾病，例如囊性纤维化，支气管炎，肺气肿等。
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公开(公告)号：US20060173010A1
公开(公告)日：2006-08-03
申请号：US11292325
申请日：2005-12-01
申请人： Scott Sneddon , John Kane , Bradford Hirth , Fred Vinick , Shuang Qiao , Sharon Nahill , John Williams , Hans-Peter Biemann
发明人： Scott Sneddon , John Kane , Bradford Hirth , Fred Vinick , Shuang Qiao , Sharon Nahill , John Williams , Hans-Peter Biemann
IPC分类号： A61K31/498 , A61K31/497 , A61K31/4965 , A61K31/4439 , A61K31/4172 , C07D403/02
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
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公开(公告)号：US20110275673A1
公开(公告)日：2011-11-10
申请号：US13119386
申请日：2009-09-17
申请人： Yibin Xiang , Bradford Hirth , John L. Kane , Junkai Liao , Kevin Noson , Christopher Yee
发明人： Yibin Xiang , Bradford Hirth , John L. Kane , Junkai Liao , Kevin Noson , Christopher Yee
IPC分类号： A61K31/454 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/4192 , A61K31/4155 , A61K31/404 , A61K31/4025 , C07D413/12 , C07D211/22 , C07D401/12 , C07D417/12 , A61K31/4196 , C07D403/12 , C07D405/12 , A61P35/00 , A61P3/10 , A61P31/18 , A61P31/12 , A61K31/45
CPC分类号： C07D211/60 , C07C215/18 , C07C237/04 , C07D207/16 , C07D213/40 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of Formula (I). Compounds of the present invention are inhibitors of sphingosine kinase 3, and are useful in the treatment of various disorders and conditions, such as inflammatory disorders.
摘要翻译： 本发明涉及式（I）的化合物。 本发明的化合物是鞘氨醇激酶3的抑制剂，可用于治疗各种疾病和病症，例如炎症性疾病。
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公开(公告)号：US20070015793A1
公开(公告)日：2007-01-18
申请号：US11019659
申请日：2004-12-22
申请人： Bradford Hirth , Glen Rennie
发明人： Bradford Hirth , Glen Rennie
IPC分类号： A61K31/445
CPC分类号： C07D211/46
摘要： Disclosed are methods of preparing substituted nojirimycins represented by the following formula, comprising reacting 1-deoxynojirimycin with a reagent prepared by reacting an oxidizing agent with the compound represented by the following formula.
摘要翻译： 公开了制备由下式表示的取代的异头孢霉素的方法，其包括使1-脱氧野尻霉素与通过氧化剂与下式表示的化合物反应制备的试剂反应。
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6.发明申请SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS 有权UDP-葡萄糖的合成：N-乙酰鞘氨醇葡糖苷酶抑制剂公开(公告)号：US20080058514A1
公开(公告)日：2008-03-06
申请号：US11895632
申请日：2007-08-24
申请人： Bradford Hirth , Craig Siegel
发明人： Bradford Hirth , Craig Siegel
IPC分类号： C07D405/10 , C07D265/36
CPC分类号： C07D405/06 , A61K31/4025 , C07D295/185 , C07D319/18 , C07D498/04
摘要： Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
摘要翻译： 公开了UDP-葡萄糖：N-酰基鞘氨醇葡糖基转移酶的新型对映体合成神经酰胺样抑制剂。 还公开了在合成过程中形成的新型中间体。
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公开(公告)号：US20050009872A1
公开(公告)日：2005-01-13
申请号：US10916824
申请日：2004-08-12
申请人： Bradford Hirth , Craig Siegel
发明人： Bradford Hirth , Craig Siegel
IPC分类号： C07D295/12 , A61K31/40 , A61K31/4025 , A61P1/16 , A61P7/06 , A61P17/02 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07B53/00 , C07B61/00 , C07D295/18 , C07D295/185 , C07D319/18 , C07D498/04 , C07D211/56 , A61K31/137 , A61K31/445
CPC分类号： C07D405/06 , A61K31/4025 , C07D295/185 , C07D319/18 , C07D498/04
摘要： Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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公开(公告)号：US08633168B2
公开(公告)日：2014-01-21
申请号：US12664628
申请日：2008-06-13
申请人： Yibin Xiang , Bradford Hirth , Cassandra Celatka
发明人： Yibin Xiang , Bradford Hirth , Cassandra Celatka
摘要： Novel mechanism-based inhibitors of S-adenosyl-L-methionine decarboxylase are provided. These compounds of formula (1) inhibit the life cycle of trypanosomes, and are useful to treat subjects infected with African trypanosomes. The invention includes pharmaceutical compositions and methods of using the compounds of formula (1).
摘要翻译： 提供了新的基于机制的S-腺苷-L-甲硫氨酸脱羧酶抑制剂。 这些式（1）化合物抑制锥虫的生命周期，并且可用于治疗感染非洲锥虫的受试者。 本发明包括药物组合物和使用式（1）化合物的方法。
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公开(公告)号：US20100261668A1
公开(公告)日：2010-10-14
申请号：US12664628
申请日：2008-06-13
申请人： Yibin Xiang , Bradford Hirth , Cassandra Celatka
发明人： Yibin Xiang , Bradford Hirth , Cassandra Celatka
摘要： Novel mechanism-based inhibitors of S-adenosyl-L-methionine decarboxylase are provided. These compounds of formula (1) inhibit the life cycle of trypanosomes, and are useful to treat subjects infected with African trypanosomes. The invention includes pharmaceutical compositions and methods of using the compounds of formula (1).
摘要翻译： 提供了新的基于机制的S-腺苷-L-甲硫氨酸脱羧酶抑制剂。 这些式（1）化合物抑制锥虫的生命周期，并且可用于治疗感染非洲锥虫的受试者。 本发明包括药物组合物和使用式（1）化合物的方法。
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10.发明申请Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors 有权UDP-葡萄糖的非对称选择性合成：N-酰基鞘氨醇葡糖基转移酶抑制剂公开(公告)号：US20050075381A1
公开(公告)日：2005-04-07
申请号：US10997474
申请日：2004-11-23
申请人： Bradford Hirth
发明人： Bradford Hirth
IPC分类号： C07D263/16 , C07D295/185 , C07D413/04 , A61K31/422 , C07D413/14
CPC分类号： C07D263/16 , C07D295/185 , C07D413/04
摘要： Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound represented by Structural Formula (II):
摘要翻译： 公开了一种制备包含结构式（I）的化合物的组合物的方法：该方法包括使醛化合物R10CHO与由结构式（II）表示的异腈化合物反应的步骤：
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