公开(公告)号：US20120157676A1

公开(公告)日：2012-06-21

申请号：US13262147

申请日：2010-03-24

申请人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

发明人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

IPC分类号： C07C209/86 ,  C07H1/06

CPC分类号： C07H5/02

摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

摘要翻译： 在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法 （DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。

公开(公告)号：US08912320B2

公开(公告)日：2014-12-16

申请号：US13262147

申请日：2010-03-24

申请人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

发明人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

IPC分类号： C07C209/86 ,  C07H1/06 ,  C07H5/02

CPC分类号： C07H5/02

摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

摘要翻译： 在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法 （DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。

公开(公告)号：US20080234472A1

公开(公告)日：2008-09-25

申请号：US12009455

申请日：2008-01-18

申请人： Duane Leinhos ,  John Kerr ,  Bob Jansen ,  Sebastien Camborieux ,  Peter Lloyd-Jones ,  Anthony Baiada

发明人： Duane Leinhos ,  John Kerr ,  Bob Jansen ,  Sebastien Camborieux ,  Peter Lloyd-Jones ,  Anthony Baiada

IPC分类号： C07H1/00

CPC分类号： C07H5/02

摘要： There is provided a method for the production of sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, and by-products including high molecular weight coloured material, said method comprising: deacylation of the sucralose-6-acylate by treatment with a base to afford sucralose, and, before or after said deacylation, removal of the reaction vehicle and isolation of the sucralose characterised in that immediately before the removal of the reaction vehicle, the reaction stream is subjected to a precipitation step comprising treatment with a metal or ammonium hydroxide and carbon dioxide to form a precipitate of the corresponding metal or ammonium carbonate in which at least a portion of said high molecular weight coloured material is trapped, followed by separation of said precipitate.

摘要翻译： 提供了从反应载体中的蔗糖-6-酰化物氯化得到的进料流中生产三氯蔗糖的方法，所述进料流包含三氯半乳蔗糖-6-酰化物，反应载体和副产物，包括 所述方法包括：用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到三氯半乳蔗糖，并且在所述脱酰化之前或之后，除去反应载体和分离三氯半乳蔗糖，其特征在于，紧接在之前 去除反应载体，将反应物流进行沉淀步骤，包括用金属或氢氧化铵和二氧化碳处理以形成相应的金属或碳酸铵的沉淀物，其中至少部分所述高分子量着色 材料被捕获，然后分离所述沉淀物。