公开(公告)号：US20080234472A1

公开(公告)日：2008-09-25

申请号：US12009455

申请日：2008-01-18

申请人： Duane Leinhos ,  John Kerr ,  Bob Jansen ,  Sebastien Camborieux ,  Peter Lloyd-Jones ,  Anthony Baiada

发明人： Duane Leinhos ,  John Kerr ,  Bob Jansen ,  Sebastien Camborieux ,  Peter Lloyd-Jones ,  Anthony Baiada

IPC分类号： C07H1/00

CPC分类号： C07H5/02

摘要： There is provided a method for the production of sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, and by-products including high molecular weight coloured material, said method comprising: deacylation of the sucralose-6-acylate by treatment with a base to afford sucralose, and, before or after said deacylation, removal of the reaction vehicle and isolation of the sucralose characterised in that immediately before the removal of the reaction vehicle, the reaction stream is subjected to a precipitation step comprising treatment with a metal or ammonium hydroxide and carbon dioxide to form a precipitate of the corresponding metal or ammonium carbonate in which at least a portion of said high molecular weight coloured material is trapped, followed by separation of said precipitate.

摘要翻译： 提供了从反应载体中的蔗糖-6-酰化物氯化得到的进料流中生产三氯蔗糖的方法，所述进料流包含三氯半乳蔗糖-6-酰化物，反应载体和副产物，包括 所述方法包括：用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到三氯半乳蔗糖，并且在所述脱酰化之前或之后，除去反应载体和分离三氯半乳蔗糖，其特征在于，紧接在之前 去除反应载体，将反应物流进行沉淀步骤，包括用金属或氢氧化铵和二氧化碳处理以形成相应的金属或碳酸铵的沉淀物，其中至少部分所述高分子量着色 材料被捕获，然后分离所述沉淀物。

公开(公告)号：US20090264633A1

公开(公告)日：2009-10-22

申请号：US12345998

申请日：2008-12-30

申请人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, JR. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

发明人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, JR. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

IPC分类号： C07H15/00

CPC分类号： C07H1/06 ,  C07H5/02

摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).

摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

公开(公告)号：US08436156B2

公开(公告)日：2013-05-07

申请号：US12345998

申请日：2008-12-30

申请人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, Jr. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

发明人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, Jr. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

IPC分类号： C07H15/00

CPC分类号： C07H1/06 ,  C07H5/02

摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).

摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

公开(公告)号：US20080308505A1

公开(公告)日：2008-12-18

申请号：US12047673

申请日：2008-03-13

申请人： Robert Jansen ,  Sebastien Camborieux ,  Genevieve Kenny ,  Richard Tanner ,  Loren Luppes ,  Anthony Baiada ,  John Kerr ,  Timothy Windebank

发明人： Robert Jansen ,  Sebastien Camborieux ,  Genevieve Kenny ,  Richard Tanner ,  Loren Luppes ,  Anthony Baiada ,  John Kerr ,  Timothy Windebank

IPC分类号： B01J20/04

CPC分类号： C02F1/5254 ,  B01D9/004 ,  B01D9/005 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2103/06 ,  C02F2103/32

摘要： We disclose a process for the removal of phosphorous and ammonia from an aqueous stream by contacting the aqueous stream with magnesium and base in a first zone having a first pH, to form an (n−1)th mixed stream and a first portion of struvite; separating the (n−1)th mixed stream from the first portion of struvite; removing at least some struvite from the first portion of struvite; contacting the (n−1)th mixed stream with base in an nth zone, wherein n is an integer incrementing from 2 to nmax, wherein nmax is an integer from 2 to about 5, and wherein the nth zone has an nth pH higher than the (n−1)th pH, to form an nth mixed stream and an nth portion of struvite, except no base is added and the nth pH need not be higher than the (n−1)th pH when n=nmax; separating the nth mixed stream from the nth portion of struvite; returning the nth portion of struvite to the (n−1)th zone; and, if n

摘要翻译： 我们公开了通过在具有第一pH的第一区域中使含水物流与镁和碱接触以形成第（n-1）混合物流和第一部分的鸟粪石来从水流中除去磷和氨的方法 ; 将第（n-1）混合物流与第一部分的鸟粪分离; 从鸟粪的第一部分去除至少一些鸟粪石; 使第（n-1）混合物流与第n区的碱接触，其中n为从2增加至nm 3的整数，其中nmax为2至约5的整数，并且其中第n个区的第n个pH高于 （n-1）pH，形成第n混合物流和第n部分的鸟粪石，除了没有碱，并且当n = nmax时，第n个pH不需要高于第（n-1）个pH; 将第n个混合物流从鸟粪的第n部分分离出来; 将第n部分的鸟粪返回到第（n-1）区; 并且如果n

公开(公告)号：US20120157676A1

公开(公告)日：2012-06-21

申请号：US13262147

申请日：2010-03-24

申请人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

发明人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

IPC分类号： C07C209/86 ,  C07H1/06

CPC分类号： C07H5/02

摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

摘要翻译： 在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法 （DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。

公开(公告)号：US08912320B2

公开(公告)日：2014-12-16

申请号：US13262147

申请日：2010-03-24

申请人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

发明人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

IPC分类号： C07C209/86 ,  C07H1/06 ,  C07H5/02

CPC分类号： C07H5/02

摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

摘要翻译： 在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法 （DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。

公开(公告)号：US20100240915A1

公开(公告)日：2010-09-23

申请号：US12696083

申请日：2010-01-29

申请人： Robert Jansen ,  Anthony Baiada ,  John Kerr ,  Peter Lloyd-Jones

发明人： Robert Jansen ,  Anthony Baiada ,  John Kerr ,  Peter Lloyd-Jones

IPC分类号： C07D307/36 ,  C07C29/76

CPC分类号： C02F1/42 ,  B01D61/36 ,  B01D61/362 ,  B01D65/08 ,  B01D2311/04 ,  B01D2311/2623 ,  B01D2321/16 ,  B01J39/04 ,  B01J39/05 ,  B01J41/04 ,  C02F1/04 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2101/34 ,  C02F2103/36 ,  C07C29/76 ,  C07C31/08 ,  C07C31/12 ,  B01J41/07

摘要： We disclose a method of extracting an alcohol or furan from a predominantly liquid stream comprising the alcohol or furan, comprising removing cations from the predominantly liquid stream comprising the alcohol or furan, using a cation-exchange resin; removing anions from the predominantly liquid stream comprising the alcohol or furan, using an anion-exchange resin; and recovering alcohol or furan from the predominantly liquid stream comprising the alcohol or furan, using either a vapor permeation membrane, a perevaporation process, or both.

摘要翻译： 我们公开了从包含醇或呋喃的主要液体流中提取醇或呋喃的方法，其包括使用阳离子交换树脂从包含醇或呋喃的主要液体流中除去阳离子; 使用阴离子交换树脂从包含醇或呋喃的主要液体流中除去阴离子; 并使用蒸气渗透膜，蒸发蒸发法或二者从包含醇或呋喃的主要液体物流中回收醇或呋喃。

公开(公告)号：US20060251762A1

公开(公告)日：2006-11-09

申请号：US11121295

申请日：2005-05-03

申请人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

发明人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

IPC分类号： A23L1/10

CPC分类号： C12P7/06 ,  Y02E50/16 ,  Y02E50/17

摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and germ. The process also includes the steps of (f) further saccharifying and fermenting the screened material with a microorganism that produces ethanol, thereby producing a broth that comprises ethanol, soluble protein, and insoluble protein, and (g) separating ethanol from the broth. A protein-rich product can be recovered from the broth that comprises both gluten from the grain and microorganism from the fermenting step.

摘要翻译： （a）在水溶液中浸渍谷物以产生软化谷粒，（b）研磨软化谷物以产生碾磨的谷物，（c）可以加工全谷物如小麦，大麦，黑麦和/或米，（c） 通过使其与淀粉酶接触并将其加热到至少约50℃的温度来液化碾磨的颗粒，产生液化材料，（d）至少部分地使液化物料与淀粉葡糖苷酶接触至少部分糖化， 约50℃，产生第一糖化物质，和（e）从第一糖化物质分离纤维和胚芽，产生基本上不含纤维和细菌的筛选材料。 该方法还包括以下步骤：（f）用生产乙醇的微生物进一步对筛选的材料进行糖化和发酵，从而产生包含乙醇，可溶性蛋白质和不溶性蛋白质的肉汤，和（g）从肉汤中分离乙醇。 富含蛋白质的产物可以从含有谷物的谷蛋白和发酵步骤的微生物的肉汤中回收。

公开(公告)号：US20060251761A1

公开(公告)日：2006-11-09

申请号：US11121170

申请日：2005-05-03

申请人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

发明人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

IPC分类号： A23L1/10

CPC分类号： C12Y302/00 ,  A23J1/125 ,  A23J3/18 ,  A23K10/30 ,  A23K20/179 ,  A23K50/80 ,  A23L7/104 ,  A23L29/35 ,  C13B20/142 ,  C13K1/08 ,  Y02A40/818

摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain or at least partially dehulled grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and wheat germ. The process also includes the steps of (f) further saccharifying the screened material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a second saccharified material, (g) membrane filtering the second saccharified material, producing a permeate that comprises primarily dextrose and other soluble components and a retentate that comprises insoluble protein, and (h) purifying the permeate by chromatographic separation, producing a purified dextrose stream. The chromatographic separation can also produce a raffinate, and the process can further include the steps of (i) combining the retentate from the membrane filtration and the raffinate from the chromatographic separation to form a fermentation medium, (j) fermenting the fermentation medium aerobically with a microorganism, (k) separating a protein product that comprises insoluble protein and microorganism from the medium, and (l) drying the protein product.

摘要翻译： 可以通过（a）在水性液体中浸渍颗粒或至少部分去壳的颗粒以产生软化的颗粒，（b）研磨软化的颗粒以产生（例如，麦粒，大麦，黑麦和/或米） （c）通过使其与淀粉酶接触并将其加热到至少约50℃的温度来液化所研磨的颗粒，产生液化材料，（d）通过使液化物质与淀粉葡糖苷酶接触而至少部分地糖化 在至少约50℃的温度下，产生第一糖化材料，和（e）从第一糖化物质分离纤维和胚芽，产生基本上不含纤维和小麦胚芽的筛选材料。 该方法还包括以下步骤：（f）通过使筛选的材料与淀粉葡糖苷酶在至少约50℃的温度下接触进一步糖化，产生第二糖化物质，（g）膜过滤第二糖化物质，产生 主要包含葡萄糖和其他可溶性组分的渗透物和包含不溶性蛋白质的渗余物，和（h）通过色谱分离纯化渗透物，产生纯化的葡萄糖流。 色谱分离还可以产生萃余液，并且该方法还可以包括以下步骤：（i）将来自膜过滤的残留物和来自色谱分离的萃余液组合以形成发酵培养基，（j）有氧地发酵发酵培养基， 微生物，（k）从培养基中分离含有不溶性蛋白质和微生物的蛋白质产物，和（l）干燥蛋白质产物。

公开(公告)号：US08404109B2

公开(公告)日：2013-03-26

申请号：US13316278

申请日：2011-12-09

申请人： Robert Jansen ,  John Kerr ,  Anthony Baiada

发明人： Robert Jansen ,  John Kerr ,  Anthony Baiada

IPC分类号： B01D17/12 ,  C13K3/00 ,  B01J14/00

CPC分类号： C13K3/00 ,  C13B20/14

摘要： A method of inverting sucrose, including (i) determining an initial solids concentration of an aqueous sucrose solution, an initial bed volume of a sucrose inversion resin system, a minimum target inversion percentage, a maximum target inversion percentage, a target maximum hydroxymethylfuran (HMF) concentration, a minimum target pH, or a maximum target pH; (ii) contacting the sucrose inversion resin system with the aqueous sucrose solution under conditions of aqueous solution flow rate and aqueous solution temperature to produce an inverted sucrose solution having an inversion percentage, an HMF concentration, and a pH; (iii) observing an instantaneous inversion percentage, an instantaneous HMF concentration, or an instantaneous pH of the inverted sucrose solution; and, if appropriate; (iv) changing at least one of the aqueous solution flow rate or the aqueous solution temperature to yield a product having a desired inversion percentage, HMF concentration, and/or pH. An apparatus capable of performing the method.

摘要翻译： 一种反相蔗糖的方法，包括（i）测定蔗糖水溶液的初始固体浓度，蔗糖反转树脂体系的初始床体积，最小目标反转百分比，最大目标反转百分比，目标最大羟甲基呋喃（HMF ）浓度，最小目标pH或最大目标pH; （ii）在水溶液流动速率和水溶液温度条件下使蔗糖反转树脂体系与蔗糖溶液水溶液接触，以产生具有倒置百分比，HMF浓度和pH值的倒置蔗糖溶液; （iii）观察反转蔗糖溶液的瞬时反转百分比，瞬时HMF浓度或瞬时pH值; 并酌情; （iv）改变水溶液流速或水溶液温度中的至少一个，得到具有所需转化百分比，HMF浓度和/或pH值的产物。 一种能够执行该方法的装置。