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公开(公告)号：US20080311080A1
公开(公告)日：2008-12-18
申请号：US12123052
申请日：2008-05-19
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎性活动，特别是胃肠道炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US20100112003A1
公开(公告)日：2010-05-06
申请号：US12479364
申请日：2009-06-05
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎性活动，特别是胃肠道炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US07390519B2
公开(公告)日：2008-06-24
申请号：US11105590
申请日：2005-04-14
申请人： John Kevin Collins , Gerald Christopher O'Sullivan , Liam O'Mahony , Fergus Shanahan , Barry Kiely
发明人： John Kevin Collins , Gerald Christopher O'Sullivan , Liam O'Mahony , Fergus Shanahan , Barry Kiely
CPC分类号： A61K35/747 , A23L33/135 , A23Y2220/79 , C12N1/20 , C12R1/225
摘要： A Lactobacillus salivarius strain, AH102, AH103, AH105, AH109 or AH110 or mutants or variants thereof are useful in the prophylaxis and/or treatment of inflammatory activity especially undesirable gastrointestinal inflammatory activity, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译： A唾液乳杆菌菌株AH102，AH103，AH105，AH109或AH110或其突变体或变体可用于预防和/或治疗炎性活动，特别是不期望的胃肠炎症活动，例如炎性肠病或肠易激综合征。
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公开(公告)号：US07195906B2
公开(公告)日：2007-03-27
申请号：US10783020
申请日：2004-02-23
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎症活性，特别是胃肠炎症活动如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US06872411B1
公开(公告)日：2005-03-29
申请号：US09701358
申请日：1999-05-26
申请人： Reynolds Paul Ross , Gerald Francis Fitzgerald , John Kevin Collins , Gerald Christopher O'Sullivan , Catherine Gerardine Stanton
发明人： Reynolds Paul Ross , Gerald Francis Fitzgerald , John Kevin Collins , Gerald Christopher O'Sullivan , Catherine Gerardine Stanton
IPC分类号： A23C19/032 , C12N1/20 , C12R1/245 , A23C9/12
CPC分类号： A23C19/072 , A23C19/0323 , A23Y2220/77 , C12R1/245
摘要： A process for the manufacture of a probiotic cheese, such as Cheddar cheese, comprises adding a 0.0-5.5% inoculum of a strain of Lactobacillus paracasei, which is non-pathogenic, acid and bile tolerant and adherent to human epithelial cells, as a starter adjunct to cheese milk, said L. paracasei strain being capable of growing during the ripening phase to a level of 107 cfu/g or greater. The L. paracasei strains are found to grow and proliferate to high cell numbers (in excess of 108 cfu/g) in the cheese over eight months of ripening, even when added at a relatively low inoculum. The presence of the L. paracasei strains is found to have negligible effects on cheese composition, flavor and aroma.
摘要翻译： 用于制造益生菌干酪例如切达干酪的方法包括将非致病性，酸和胆汁耐受性和粘附于人上皮细胞的副干酪乳杆菌菌株的0.0-5.5％接种物作为起始物 所述副干酪乳杆菌菌株能够在成熟阶段生长至10 7 cfu / g或更高的水平。 发现副干酪乳杆菌菌株在八个月的成熟期间在奶酪中生长和增殖至高细胞数（超过10 8 cfu / g），即使在相对较低的接种物中加入。 发现副干酪乳杆菌菌株的存在对奶酪成分，风味和香气的影响可以忽略不计。
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6.发明授权Probiotic strains from Lactobacillus salivarius and antimicrobial agents obtained therefrom 有权来自唾液乳杆菌的益生菌菌株和由其获得的抗微生物剂公开(公告)号：US07186545B2
公开(公告)日：2007-03-06
申请号：US10606114
申请日：2003-06-26
申请人： John Kevin Collins , Gerald Christopher O'Sullivan , Gerardine Mary Thornton , Marian Mary Geraldine O'Sullivan
发明人： John Kevin Collins , Gerald Christopher O'Sullivan , Gerardine Mary Thornton , Marian Mary Geraldine O'Sullivan
IPC分类号： C12N1/20
CPC分类号： C12R1/225 , A23L29/065 , A23Y2220/77 , A61K35/747 , C07K14/335
摘要： A strain of Lactobacillus salivarius isolated from resected and washed human gastrointestinal tract inhibits a broad range of Gram positive and Gram negative microorganisms and secretes a product having antimicrobial activity into a cell-free supernatant. The activity is produced only by, growing cells and is destroyed by proteinase K and pronase E, the inhibitory properties of the strain and its secretory products being maintained in the presence of physiological concentrations of human bile and human gastric juice. The strain exhibits a broad-spectrum of activity against bacteria including Listeria, Staphylococcus, including methocillin resistant St. aureus (MRSA), and Bacillus, but does not inhibit many closely related lactobacilli. An antimicrobial agent is obtained from the strain which has bacteriocin-like properties.
摘要翻译： 从切除和洗涤的人类胃肠道分离的唾液乳杆菌菌株抑制广泛的革兰氏阳性和革兰氏阴性微生物，并将具有抗微生物活性的产物分泌到无细胞上清液中。 该活性仅由生长细胞产生并被蛋白酶K和链霉蛋白酶E破坏，菌株及其分泌产物的抑制性质在生理浓度的人胆汁和人胃液存在下保持。 该菌株对李斯特菌，葡萄球菌（包括耐甲氧西林金黄色葡萄球菌（MRSA））和芽孢杆菌（Bacillus）具有广谱的活性，但不抑制许多密切相关的乳杆菌。 从具有细菌素样性质的菌株获得抗微生物剂。
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