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公开(公告)号：US07048716B1
公开(公告)日：2006-05-23
申请号：US09448720
申请日：1999-11-24
CPC分类号： A61M25/0043 , A61M25/0108 , A61M25/0127 , G01R33/285
摘要： A catheter is used for medical treatments within an organism. The catheter comprises at least one lumen. Within the at least one lumen are at least two microcatheters, with at least one of the at least two microcatheters being connected to a source of liquid material to be delivered to the organism and another of the at least two microcatheters being connected to a system capable of effecting a medical treatment other than delivery of the liquid.
摘要翻译： 导管用于生物体内的医疗治疗。 导管包括至少一个内腔。 所述至少一个腔内至少有两个微导管，所述至少两个微导管中的至少一个微小导管连接到待传递给所述生物的液体材料源，并且所述至少两个微导管中的另一个连接到能够 除了输送液体之外进行医疗。
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公开(公告)号：US06994841B1
公开(公告)日：2006-02-07
申请号：US09189043
申请日：1998-11-09
IPC分类号： A61B5/055
CPC分类号： G01R33/563 , A61B5/0263 , A61B5/0275 , G01R33/5601 , G01R33/56366
摘要： The invention shows a method for obtaining temporally spaced images of tissues, including blood vessels, to reveal blood flow abnormalities within those tissues and vessels.
摘要翻译： 本发明示出了用于获得包括血管在内的组织的时间间隔图像以显示那些组织和血管内的血流异常的方法。
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公开(公告)号：US5833947A
公开(公告)日：1998-11-10
申请号：US604778
申请日：1996-02-23
IPC分类号： A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method comprising the steps of: administering said substance into said body; administering into the systemic vasculature of said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent; subjecting said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, said procedure being a fast imaging procedure having an image acquisition time of less than five seconds; and detecting temporal variations in said signals or images whereby to monitor the vasoconstriction or vasodilation induced by said substance.
摘要翻译： 本发明提供了监测施用于人或非人动物体的生理活性物质的血管扩张或血管收缩作用的方法，所述方法包括以下步骤：将所述物质施用于所述体内; 对所述体内的系统性脉管系统施用对比度增加量的含血管内顺磁性金属的磁共振成像造影剂; 对所述身体进行磁共振成像程序，所述磁共振成像程序能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述过程是具有图像采集的快速成像过程 时间少于5秒; 以及检测所述信号或图像中的时间变化，从而监测由所述物质引起的血管收缩或血管舒张。
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4.发明授权Imaging methods for early detection of brain tumors following embryonic stem cell implants 失效用于早期检测胚胎干细胞植入物后脑肿瘤的成像方法公开(公告)号：US08706187B2
公开(公告)日：2014-04-22
申请号：US11386394
申请日：2006-03-22
IPC分类号： A61B5/055
CPC分类号： A61B5/413 , A61B5/055 , A61B5/14532 , A61B5/4082 , G01R33/54
摘要： Non-invasive imaging methods and minimally invasive sensing methods are used for assessing the viability of cells implanted in the central nervous system for therapeutic purposes and for detecting the transformation of such cells, including embryonic stem cells, into brain tumors. In particular, the present invention provides an imaging means for differentiating normal cell proliferation and angiogenesis following a cell implant from abnormal tumor growth and neovascularization associated with teratoma-inducing implanted embryonic stem cells.
摘要翻译： 非侵入性成像方法和微创感测方法用于评估植入中枢神经系统中用于治疗目的的细胞的存活力，并用于检测这些细胞（包括胚胎干细胞）转化入脑肿瘤。 特别地，本发明提供了一种用于区分正常细胞增殖和细胞植入之后的异常肿瘤生长和与引起畸胎瘤的植入胚胎干细胞相关的新生血管形成的成像装置。
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5.发明授权Magnetic resonance apparatus for use with active electrode and drug deliver catheter 有权用于活性电极和药物输送导管的磁共振装置公开(公告)号：US07505807B1
公开(公告)日：2009-03-17
申请号：US09566798
申请日：2000-05-08
IPC分类号： A61B5/055
CPC分类号： A61M31/005 , A61B5/14525 , A61B17/3421 , A61B90/11 , A61B2034/2051 , A61B2090/3954 , A61B2090/3958 , A61B2562/17 , A61M2025/0057 , A61M2025/0073 , A61M2210/06 , A61M2210/0693 , G01R33/281 , G01R33/285 , G01R33/286 , G01R33/287 , G01R33/5601 , G01R33/563 , G01R33/56341
摘要： The invention is an apparatus and method for treatments and targeted drug delivery into a living patient, particularly but not exclusively using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spinal distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译： 本发明是一种用于治疗和靶向药物递送到生命患者中的装置和方法，特别但不排他地使用磁共振（MR）成像。 该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。 定位在靶位点（例如，颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。 使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药物的脊髓分布动力学，以确定靶向位置的药物递送的功效。
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公开(公告)号：US6061587A
公开(公告)日：2000-05-09
申请号：US856894
申请日：1997-05-15
CPC分类号： G01R33/5601 , A61M31/005 , A61B2034/2051 , A61B2090/365 , A61B2090/3958 , A61B90/11 , A61M2025/0057 , A61M2025/0073 , A61M2210/0693 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
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公开(公告)号：US6026316A
公开(公告)日：2000-02-15
申请号：US857043
申请日：1997-05-15
IPC分类号： A61M25/00 , A61M31/00 , G01R33/28 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61M31/005 , A61M2025/0036 , A61M2025/004 , A61M2025/0057 , A61M2025/0073 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译： 本发明是使用磁共振（MR）成像将靶向药物递送至生活患者的装置和方法。 该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。 定位在靶位点（例如颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。 使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药剂的空间分布动力学，以确定靶向位置的药物递送的功效。
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8.发明授权Methods for detecting blood perfusion variations by magnetic resonance imaging 失效通过磁共振成像检测血液膨胀变化的方法
公开(公告)号：US5190744A
公开(公告)日：1993-03-02
申请号：US490859
申请日：1990-03-09
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of detecting blood flow abnormality or variation in a human or non-human body, said method comprising administering into the cardiovascular system of a said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent, subject said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, and detecting temporal variations in said signals or images whereby to identify regions of abnormal or modified blood flow in said body and to indicate the degree of blood flow abnormality or modification therein.
摘要翻译： 本发明提供一种检测人体或非人体血流异常或变异的方法，所述方法包括向所述体内的心血管系统施用对比度增加量的含有血管内顺磁性金属的磁共振成像造影剂，对象 所述身体到磁共振成像程序，其能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述代理人通过该图像，并且检测所述信号或图像中的时间变化，从而识别 所述身体中异常或改变的血流的区域，并指示其中的血流异常或改变的程度。
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公开(公告)号：US20220054153A1
公开(公告)日：2022-02-24
申请号：US17460210
申请日：2021-08-28
IPC分类号： A61B17/221
摘要： An intravascular thrombus retraction device and method utilizing wires compressible into a compact form within a catheter and are self-expandable into a wire mesh web with fluid-penetrable openings in the wire mesh small enough to filter clot particles. A base of the wire mesh web is connected to a radially ring-shaped structure supporting and maintaining an opening in the base of the wire mesh and forming a thrombus capture volume. The ring-shaped structure is compressible into the catheter and is self-expandable when free of compressive forces within the catheter to open up into the open, expanded ring-shaped structure, maintaining the opening in the opening in the base of the wire mesh.
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公开(公告)号：US20110230909A1
公开(公告)日：2011-09-22
申请号：US13152004
申请日：2011-06-02
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/1219 , A61B17/221 , A61B17/32056 , A61B2017/22034 , A61B2017/2212 , A61F2002/016 , A61F2230/0078 , A61F2230/0091
摘要： A device capable of capturing and facilitating the removal of a thrombus in blood vessels (or stones in biliary or urinary ducts, or foreign bodies) uses a soft coil mesh with the aid of a pull wire or string to engage the surface of a thrombus, and remove the captured thrombus. The soft coil mesh is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical elements forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. The use of multiple coil mesh elements, delivered through a single lumen or multiple lumens, preferably with separate control of at least one end of each coil, provides a firm grasp on a distal side of a thrombus, assisting in non-disruptive or minimally disrupted removal of the thrombus upon withdrawal of the device.
摘要翻译： 能够捕获和促进血管（或胆管或泌尿道或异物中的石块）的去除的装置使用软线圈网，借助于拉丝或绳子来接合血栓的表面， 并取出捕获的血栓。 软线圈网由形成大量线圈元件的螺旋元件的细长的微线圈元件形成。 微线圈元件对形成大螺线管的螺旋元件提供相对弹性的效果，并且允许控制血栓上的夹持力，同时减少装置与动脉壁的非刚性接触。 使用通过单个腔或多个流明递送的多个线圈网状元件，优选地具有每个线圈的至少一个端部的单独控制，在血栓的远端侧提供牢固的抓握，辅助非破坏性或最小程度的破坏 取出装置时取出血栓。
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