公开(公告)号：US20090215853A1

公开(公告)日：2009-08-27

申请号：US11579608

申请日：2005-05-19

申请人： John L. Hall ,  Sylvie Beljanski

发明人： John L. Hall ,  Sylvie Beljanski

IPC分类号： A61K31/405

CPC分类号： A61K36/24 ,  A61K31/475 ,  A61K2300/00

摘要： A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and/or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.

摘要翻译： 通过施用有效量的黄曲霉素和阿尔斯汀的混合物，预防前列腺癌和/或降低PSA水平和/或减轻BPH（良性前列腺增生症）或PIN（前列腺上皮内瘤变）的症状的方法和组合物。 用于治疗低级前列腺癌并预防转移性疾病发作和/或减少具有阳性活组织检查的男性PSA水平倍增时间的方法和组合物显示出相对较低的格列森评分和非侵入性，缓慢进展的前列腺特征的形态 癌症。 黄曲霉素和阿司匹林可以分别是由派佩雷拉（Pao Pereira）和萝维（Rauwolfia Vomitoria）衍生的天然提取物。 或者，这两种活性化合物可以以纯化形式施用。 组合物可以包含在试剂盒中以及用于治疗方案的说明书中。

公开(公告)号：US5614157A

公开(公告)日：1997-03-25

申请号：US361585

申请日：1994-12-22

申请人： John L. Hall

发明人： John L. Hall

IPC分类号： A61L11/00 ,  B09B3/00 ,  A61L2/04

CPC分类号： A61L11/00 ,  B09B3/0025 ,  B09B3/0075 ,  Y10S241/606

摘要： Apparatus for treating infectious wastes from hospitals, medical clinics or the like integrates sterilizing, fragmentizing and compaction steps within a single waste processor. Wastes which are deposited in a sterilization chamber are made non-infectious by exposure to pressurized steam. An outflow of wastes from the sterilization chamber is fed through one or more on-line shredders or the like and then into a compactor which compresses the processed material into a transportable container that may be hauled to a dump site.

摘要翻译： 用于治疗来自医院，医疗诊所等的感染性废物的装置在单个废物处理器内集成消毒，分段和压实步骤。 沉积在灭菌室中的废物通过暴露于加压蒸汽而变得不感染。 来自灭菌室的废物流出通过一个或多个在线破碎机等进料，然后进入压实机，压实机将经处理的材料压缩成可以运送到倾倒场所的运输容器。

公开(公告)号：US5389347A

公开(公告)日：1995-02-14

申请号：US130189

申请日：1993-10-01

申请人： John L. Hall

发明人： John L. Hall

IPC分类号： A61L11/00 ,  B09B3/00 ,  A61L2/04

CPC分类号： B09B3/0025 ,  A61L11/00 ,  B09B3/0075 ,  Y10S241/606

摘要： Hospital wastes or the like are sterilized and compressed for disposal by apparatus having a waste receptacle with a waste receiving opening at the top and having a sterilizer casing, the receptacle and casing being in telescoping relationship. The receptacle initially protrudes from the casing in order to receive the wastes and is then translated into the casing to close the casing and thereby enable sterilization of the contents by admission of pressurized steam. A helical rotary conveyer extends along the axis of the receptacle and has several functions. The conveyer moves wastes from the receptacle into the casing and precompacts such wastes prior to the sterilization cycle and may be used to stir the wastes during sterilization. After opening of a casing door, the conveyer operates to discharge the sterile wastes from the casing and a translatable ram forces the material into an adjacent compactor container.

摘要翻译： 医院废物等被灭菌和压缩以便通过具有在顶部具有废物接收开口的废物容器的设备进行处理并具有灭菌器壳体，所述容器和壳体处于伸缩关系。 容器最初从壳体突出以便接收废物，然后被翻译成壳体以封闭壳体，由此允许加压蒸汽进入内容物进行灭菌。 螺旋式旋转输送机沿着插座的轴线延伸并具有多种功能。 输送机将废物从容器移动到壳体中，并在灭菌周期之前预先混合这些废物，并可用于在灭菌期间搅拌废物。 在打开套管门之后，输送机操作以从壳体排出无菌废物，并且可平移的压头迫使材料进入相邻的压实容器。

公开(公告)号：US4589535A

公开(公告)日：1986-05-20

申请号：US650951

申请日：1984-09-17

申请人： John L. Hall ,  Dennis R. Shamine ,  James P. Koenig

发明人： John L. Hall ,  Dennis R. Shamine ,  James P. Koenig

IPC分类号： F01P7/08 ,  F16D25/0638 ,  F16D43/25 ,  F16D13/70 ,  F16D13/74

CPC分类号： F16D25/0638 ,  F01P7/085 ,  F16D43/25

摘要： A clutch assembly includes an input member, an output member, and clutch plates connected to the input and output members which are driven into drive engagement with one another when the clutch is engaged to connect the output member for rotation with the input member. The clutch plates carried on the input member are mounted on a separate clutch plate carrying member, which is machined before installation on the input member to thereby facilitate manufacture and assembly of the device. A fluid pressure responsive piston operates the clutch plates, and has an outer diameter slidingly and sealingly engaged with the wall to bore of the housing of the input or driving member, and its inner diameter slidingly engaged with an annular retainer which is mounted for rotation with the input member. A pair of roller bearings mount the input or driving member on a fixed spindle and on the output member, and bypass passages are provided around the bearings to assure that fluid pressure can be relieved from oil seals sealing the bore and the bearings within the housing defined by the input or driving member.

摘要翻译： 离合器组件包括输入构件，输出构件和连接到输入和输出构件的离合器板，当离合器接合以将输出构件与输入构件旋转连接时，离合器板被彼此驱动接合。 承载在输入构件上的离合器片安装在单独的离合器片承载构件上，其在安装之前在输入构件上被加工，从而有助于装置的制造和组装。 流体压力响应活塞操作离合器片，并且具有与输入或驱动构件的壳体的壁滑动并密封地接合的外径，并且其内径与环形保持器滑动接合，环形保持器安装成与 输入成员。 一对滚子轴承将输入或驱动构件安装在固定的主轴和输出构件上，旁路通道设置在轴承周围，以确保流体压力可以从密封孔中的油封和轴承内部定义 由输入或驱动构件。

公开(公告)号：US3985214A

公开(公告)日：1976-10-12

申请号：US529412

申请日：1974-12-04

申请人： John L. Hall ,  Gilbert A. Pataky

发明人： John L. Hall ,  Gilbert A. Pataky

IPC分类号： F01P7/08 ,  F16D25/08 ,  F16D43/25

CPC分类号： F16D43/25 ,  F01P7/085 ,  F16D25/082

摘要： A clutched fan drive for a vehicle engine is disclosed which couples the engine cooling fan to a member driven by the vehicle engine when the engine coolant temperature exceeds a predetermined level, and which uncouples the fan when the engine temperature level falls below the predetermined level. The fan drive includes a driving member which is rotatably mounted on a fixed spindle, a ram piston which is slidably mounted on the spindle, and a driven member which is rotatably mounted on the ram piston and which is movable therewith. The engine coolant fan is coupled to the driven member, and both the driven member and the driving member are provided with a clutching mechanism which is engaged by a resilient spring which acts against the ram piston. Consequently, the disclosed clutch fan drive requires no complicated and expensive load transmitting splines between the clutch elements and further requires no rotating pressure seals or complicated bearings which must accommodate both rotation and translatory movement.

摘要翻译： 公开了一种用于车辆发动机的离合器风扇驱动器，其在发动机冷却剂温度超过预定水平时将发动机冷却风扇耦合到由车辆发动机驱动的构件，并且当发动机温度水平低于预定水平时，将风扇分流。 风扇驱动器包括可旋转地安装在固定主轴上的驱动构件，可滑动地安装在主轴上的活塞活塞，以及可旋转地安装在压头活塞上并随其移动的从动构件。 发动机冷却风扇联接到从动构件，并且从动构件和驱动构件都设置有离合机构，该离合机构由抵靠活塞活塞的弹性弹簧接合。 因此，所公开的离合器风扇驱动器不需要离合器元件之间的复杂和昂贵的负载传递花键，并且不需要旋转的压力密封或必须适应旋转和平移运动的复杂的轴承。

公开(公告)号：US07341749B2

公开(公告)日：2008-03-11

申请号：US11132183

申请日：2005-05-19

申请人： John L. Hall ,  Sylvie P. Beljanski

发明人： John L. Hall ,  Sylvie P. Beljanski

IPC分类号： A61K36/00 ,  A61K36/89 ,  A61K31/535 ,  A61K31/50

CPC分类号： A61K36/24 ,  A61K31/475 ,  A61K2300/00

摘要： A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and/or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.

摘要翻译： 通过施用有效量的黄曲霉素和阿尔斯汀的混合物，预防前列腺癌和/或降低PSA水平和/或减轻BPH（良性前列腺增生症）或PIN（前列腺上皮内瘤变）症状的方法和组合物。 用于治疗低级前列腺癌并预防转移性疾病发作和/或减少具有阳性活组织检查的男性PSA水平倍增时间的方法和组合物显示出相对较低的格列森评分和非侵入性，缓慢进展的前列腺特征的形态 癌症。 黄曲霉素和阿司匹林可以分别是由派佩雷拉（Pao Pereira）和萝维（Rauwolfia Vomitoria）衍生的天然提取物。 或者，这两种活性化合物可以以纯化形式施用。 组合物可以包含在试剂盒中以及用于治疗方案的说明书中。

公开(公告)号：US5470546A

公开(公告)日：1995-11-28

申请号：US264988

申请日：1994-06-24

申请人： John L. Hall

发明人： John L. Hall

IPC分类号： A61L11/00 ,  A61L2/06

CPC分类号： A61L11/00 ,  Y10S588/90

摘要： A fluid tight waste materials receptacle is located within a housing which has an upper access opening through which infectious wastes from medical clinics or the like may be deposited in the receptacle. A lower access opening enables entry and withdrawal of a sterilized waste receiver which may, for example, be a wheeled cart. The receptacle has an open end and a closed end and is pivotable between a first orientation at which the open end is coincident with the upper access opening in order to receive wastes and a second orientation at which the open end is turned downward to discharge wastes into the receiver. A closure pivoted to the housing seats in and seals the open end of the receptacle when it is at the first orientation. The receptacle is periodically evacuated and steam is admitted to sterilize the contents prior to discharge into the receiver.

摘要翻译： 流体密封的废物容器位于壳体内，该壳体具有上部进入开口，来自医疗诊所等的传染性废物可以通过该入口开口沉积在容器中。 下部进入开口使得能够进入和取出例如可以是轮式推车的灭菌废物接收器。 容器具有开口端和封闭端，并且可在第一方向和第二方向之间枢转，第一方位与开口端与上通道开口重合，以便接收废物，第二方向可转动，开口端向下转动以将废物排放到 收件人。 当容器处于第一方向时，闭合件枢转到壳体座部并密封容器的开口端。 定期抽吸容器，并允许蒸汽在放入接收器之前对内容物进行消毒。

公开(公告)号：US4830161A

公开(公告)日：1989-05-16

申请号：US102051

申请日：1987-09-25

申请人： John L. Hall ,  David T. Fenzel ,  Dennis R. Shamine

发明人： John L. Hall ,  David T. Fenzel ,  Dennis R. Shamine

IPC分类号： F01P7/08 ,  F16D25/0632 ,  F16D25/08

CPC分类号： F01P7/085 ,  F16D25/082

摘要： A clutch drive for a vehicle engine cooling fan includes a pulley portion which is driven by the vehicle engine, a fan plate which rotatably mounts the engine cooling fan, and a pressure plate which engages the fan plate to drive the latter when the clutch is engaged. Torque transmission from the pulley to the pressure plate is through a series of circumferentially spaced coiled springs which also yieldabel urge the pressure plate into driving engagement with the fan plate. A spring stabilizer defines a circumferentially extending cavity which receives several coils of the spring to stabilize the latter and to prevent displacement of the coils circumferentially with respect to each other during engagement and disengagement of the clutch. The stabilizer also slidably engages both the pressure plate and the pulley, thereby taking up clearances between the various members to prevent rattling and also to assist in the transmission of torque to the pressure plate.

摘要翻译： 用于车辆发动机冷却风扇的离合器驱动器包括由车辆发动机驱动的滑轮部分，可旋转地安装发动机冷却风扇的风扇板和当离合器接合时与风扇板接合以驱动风扇板的压力板 。 从滑轮到压板的扭矩传递是通过一系列周向间隔开的螺旋弹簧，其也使压力板促使压板与风扇板驱动接合。 弹簧稳定器限定了周向延伸的空腔，其容纳弹簧的若干线圈以稳定弹簧，并且在接合和离合离合器期间防止线圈相对于彼此周向相对移动。 稳定器还可滑动地接合压板和皮带轮，从而吸收各个构件之间的间隙，以防止发出咔嗒声，并且还有助于将扭矩传递到压力板。

公开(公告)号：US4590597A

公开(公告)日：1986-05-20

申请号：US612291

申请日：1984-05-21

申请人： Ma Long-sheng ,  Leo Hollberg ,  Jon H. Shirley ,  John L. Hall

发明人： Ma Long-sheng ,  Leo Hollberg ,  Jon H. Shirley ,  John L. Hall

IPC分类号： H01S3/139 ,  H01S3/13

CPC分类号： H01S3/1392 ,  H01S3/1398

摘要： A method and apparatus are disclosed for precisely stabilizing a laser to a sub-Doppler resonance of an absorbing gas contained in a cell located external to the laser resonator. Stabilization is based on the detection of modulation transferred onto a previously unmodulated probe beam by the non-linear interactions of the absorbing gas located in a cell which is subject to a counter-running, frequency-modulated saturation beam. Alternatively, the further modulation of the saturation beam can be detected.

摘要翻译： 公开了一种用于将激光精确地稳定在包含在位于激光谐振器外部的单元中的吸收气体的亚多普勒共振的方法和装置。 稳定是基于通过位于经受反向运行的频率调制的饱和波束的小区中的吸收气体的非线性相互作用来检测传输到先前未调制的探测光束的调制。 或者，可以检测饱和光束的进一步调制。

公开(公告)号：US06850543B2

公开(公告)日：2005-02-01

申请号：US10240380

申请日：2001-03-29

申请人： Steven T. Cundiff ,  John L. Hall ,  Scott A. Diddams ,  David J. Jones

发明人： Steven T. Cundiff ,  John L. Hall ,  Scott A. Diddams ,  David J. Jones

IPC分类号： H01S3/098 ,  H01S3/139 ,  H01S3/16 ,  H01S3/10

CPC分类号： H01S3/1112 ,  H01S3/0805 ,  H01S3/0811 ,  H01S3/1307 ,  H01S3/139 ,  H01S3/1398 ,  H01S3/1625 ,  H01S3/1636

摘要： Disclosed is a system and method for stabilizing the carrier-envelope phase of the pulses emitted by a femtosecond mode-locked laser by using the powerful tools of frequency-domain laser stabilization. Control of the pulse-to-pulse carrier-envelope phases was confirmed using temporal cross correlation. This phase stabilization locks the absolute frequencies emitted by the laser, which is used to perform absolute optical frequency measurements that were directly referenced to a stable microwave clock.

摘要翻译： 公开了一种通过使用强大的频域激光稳定工具来稳定由飞秒锁模激光器发射的脉冲的载波包络相位的系统和方法。 使用时间互相关确认脉冲到脉冲载波包络相的控制。 该相位稳定锁定激光器发射的绝对频率，用于执行直接参考稳定微波时钟的绝对光频率测量。