公开(公告)号：US20090221492A1

公开(公告)日：2009-09-03

申请号：US12201673

申请日：2008-08-29

申请人： William H. Velander ,  William N. Drohan ,  Henryk Lubon ,  John L. Johnson ,  Mary Ann H. Johnson

发明人： William H. Velander ,  William N. Drohan ,  Henryk Lubon ,  John L. Johnson ,  Mary Ann H. Johnson

IPC分类号： A61K38/16 ,  A01K67/027 ,  C12P21/00 ,  C12N5/00 ,  C07K14/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/108 ,  A01K2267/01 ,  A01K2267/03 ,  A61K38/36 ,  C12N9/644 ,  C12Y304/21022

摘要： Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5′-untranslated and 3′-untranslated region, which is substituted with a 5-′ and 3′-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described.

摘要翻译： 可以在掺入根据本发明的嵌合DNA分子的转基因动物的乳中获得以高百分比的活性蛋白为特征的重组因子IX。 本发明的转基因动物通过引入编码因子IX的发育中的胚胎DNA而产生，使得外源DNA稳定地并入成熟动物的种系细胞的DNA中。 使用包含乳腺特异性启动子的嵌合构建体，缺乏5'和3'非翻译区的完整或任何部分的因子IX cDNA，其被5'和3' -end的小鼠乳清酸性蛋白基因。 还描述了从本发明的转基因哺乳动物移出的细胞的体外细胞培养物和从所述培养物生产因子IX的方法和治疗血友病B的方法。

公开(公告)号：US07552074B2

公开(公告)日：2009-06-23

申请号：US11462268

申请日：2006-08-03

申请人： Heather Bruce ,  Doug Stewart ,  Margaret A. Henry ,  Jacquelyn S. Rongish ,  Gretchen L. Donlin ,  Matthew A. Rademacher ,  John L. Johnson ,  Jeffrey A. Harpenau ,  Michael B. Grear

发明人： Heather Bruce ,  Doug Stewart ,  Margaret A. Henry ,  Jacquelyn S. Rongish ,  Gretchen L. Donlin ,  Matthew A. Rademacher ,  John L. Johnson ,  Jeffrey A. Harpenau ,  Michael B. Grear

IPC分类号： G06Q40/00

CPC分类号： G06Q20/04 ,  G06Q40/00

摘要： A network for managing account addresses (such as for credit card accounts) where correspondence and other communications mailed to account holders may have different purposes (e.g., credit card statement, new credit card, marketing correspondence). The network has a database for storing addresses and a database management system for retrieving those addresses. A default address is provided when there is no address stored in the database for the intended purpose of a mailing. The addresses are in categories, with each category associated with a different communication purpose, and with multiple addresses in each category. The multiple addresses within each category may be permanent, temporary or repeating. If temporary or repeating, effective start and end dates are associated with the addresses. There may be multiple cardholders for each account, in which case the address categories (and multiple addresses within each category) are associated with each cardholder.

摘要翻译： 用于管理帐户地址（例如信用卡账户）的网络，其中邮寄给账户持有者的通信和其他通信可以具有不同的目的（例如，信用卡对帐单，新的信用卡，营销通信）。 该网络具有用于存储地址的数据库和用于检索这些地址的数据库管理系统。 当数据库中没有存储地址用于邮寄的预期目的时，将提供默认地址。 地址分类，每个类别与不同的通信目的相关联，并且每个类别中有多个地址。 每个类别中的多个地址可能是永久的，暂时的或重复的。 如果临时或重复，有效的开始和结束日期与地址相关联。 每个帐户可能有多个持卡人，在这种情况下，每个持卡人都会将地址类别（和每个类别中的多个地址）关联起来。

公开(公告)号：US5598053A

公开(公告)日：1997-01-28

申请号：US409463

申请日：1995-03-20

申请人： John L. Johnson ,  Kevin L. Landel

发明人： John L. Johnson ,  Kevin L. Landel

IPC分类号： H01J29/89 ,  H04N5/74 ,  H01J29/10 ,  G02F1/13

CPC分类号： H04N5/7441 ,  H01J29/89 ,  H01J2229/8926

摘要： An LCD projection system, located within a standard color CRT, is used to oject toward the screen decay stimulation patterns that vary dynamically from one frame to the next for each pixel based on the video signals received from external sources. This controls the output light intensity of the phosphors that are excited by a single electron gun. This system eliminates the three-electron-gun configuration of the standard CRT as well as the requirement of a shadow mask. What results is a CRT that is more rugged, easier to manufacture and that produces brighter and sharper images on its screen.

摘要翻译： 位于标准彩色CRT内的LCD投影系统用于基于从外部源接收的视频信号向每个像素的一帧向下移动的屏幕衰减刺激图案投影。 这控制了由单个电子枪激发的荧光体的输出光强度。 该系统消除了标准CRT的三电子枪配置以及荫罩的要求。 CRT的结果是更坚固，更容易制造，并在其屏幕上产生更明亮和更清晰的图像。

公开(公告)号：US5523222A

公开(公告)日：1996-06-04

申请号：US286495

申请日：1994-08-05

申请人： Raymond L. Page ,  William H. Velander ,  John L. Johnson

发明人： Raymond L. Page ,  William H. Velander ,  John L. Johnson

IPC分类号： A01K67/027 ,  C12N9/64 ,  C12N15/89 ,  C12N5/00 ,  C12N15/00

CPC分类号： A01K67/0275 ,  C12N15/89 ,  C12N9/6464 ,  C12Y304/21069 ,  A01K2217/05

摘要： The present invention provides a method of obtaining an organism which has been characterized as having cells containing exogenous genetic material which includes any sequence of DNA that can be distinguished as exogenous by known molecular biological analysis by insertion of genetic material into an animal's genetic makeup. The insertion of the genetic material is done by inserting DNA that has been complexed with molecules that allow the DNA to be inserted into the chromosomes when injected into the cytoplasm, perivitelline space, or placed in surrounding culture media to be taken up and incorporated into the genome. When the DNA is complexed into the polyelectrolyte molecules by electrostatic attraction, the electric charge of DNA of the complex is partially to substantially neutralized. The present method does not require the genetic material to be introduced into the embryo at a particular stage in development.

摘要翻译： 本发明提供了一种获得生物体的方法，其特征在于具有含有外源性遗传物质的细胞，其包括可通过已知的分子生物学分析通过将遗传物质插入到动物的遗传组合中而被区分为外源的任何DNA序列。 遗传材料的插入是通过插入已经与允许将DNA插入细胞质，细胞周围空间中的DNA插入到染色体中的分子组合的DNA来完成的，或者放置在周围的培养基中以被吸收并掺入到 基因组 当通过静电吸引将DNA复合成聚电解质分子时，络合物的DNA的电荷被部分地基本上中和。 本发明的方法不需要在发育的特定阶段将遗传物质引入胚胎。

公开(公告)号：US4923263A

公开(公告)日：1990-05-08

申请号：US247555

申请日：1988-09-22

申请人： John L. Johnson

发明人： John L. Johnson

IPC分类号： G02B26/10

CPC分类号： G02B26/10

摘要： An optical scanning device for mechanically scanning images at a high scanate over a wide field of view and under low light conditions. The device comprises a first rotating reflecting means such as mirrors for intersecting an input beam of light in a first path and for redirecting the beam of light into a second path. A second rotating reflecting means intersects the second path and reflects the beam of light into a third path, onto a detecting device for detecting the presence of predetermined images in the beam of light. In order to reflect the light beams over an elliptical path the mirrors are mounted on rotating shafts at a slight angle from the perpendicular to the axis of the rotating shaft. The mirrors are rotated at varying speed relationships to each other and varying phase relationships to each other in order to produce a variety of scan patterns.

摘要翻译： 一种用于在宽视场和低光条件下以高扫描速率机械扫描图像的光学扫描装置。 该装置包括第一旋转反射装置，例如用于与第一路径中的输入光束交叉的反射镜，并用于将光束重定向到第二路径。 第二旋转反射装置与第二路径相交并将光束反射到第三路径中，到达用于检测光束中预定图像的存在的检测装置。 为了将光束反射在椭圆形路径上，镜子以与旋转轴的轴线垂直的角度微小的角度安装在旋转轴上。 反射镜以彼此变化的速度关系旋转并且彼此改变相位关系，以便产生各种扫描图案。

公开(公告)号：US4630632A

公开(公告)日：1986-12-23

申请号：US674742

申请日：1984-11-26

申请人： John L. Johnson

发明人： John L. Johnson

IPC分类号： F16K31/42 ,  G05D16/10 ,  G05D16/20 ,  F16K31/363

CPC分类号： G05D16/2093 ,  Y10T137/2409 ,  Y10T137/86919 ,  Y10T137/87225

摘要： A regulator is provided in which the bias which urges the unseating of the regulating valve is a piston having a plurality of radial working surfaces, each in its own separate pressure chamber. The chambers are connected to the inlet selectively, singly or in combination, by solenoid valves. The unseating of the regulating valve is opposed by the outlet pressure which works on the entire back side of the piston. In the preferred form a relationship exists between the relative sizes of the individual piston working surfaces so that all the possible outlet pressures attainable by the regulator are equispaced, all the way from 0 psig to the highest regulated pressure.

摘要翻译： 提供了一种调节器，其中促使调节阀转动的偏压是具有多个径向工作表面的活塞，每个在其独立的压力室中。 这些室通过电磁阀单独或组合地连接到入口。 调节阀的脱落与在活塞的整个后侧工作的出口压力相反。 在优选形式中，各个活塞工作表面的相对尺寸之间存在关系，使得由调节器可达到的所有可能的出口压力等距，从0psig到最高调节压力。

公开(公告)号：US4624563A

公开(公告)日：1986-11-25

申请号：US558000

申请日：1983-12-05

申请人： John L. Johnson

发明人： John L. Johnson

IPC分类号： G01S3/783 ,  G01C1/00 ,  G01J4/00

CPC分类号： G01S3/783

摘要： A laser position sensor system for viewing a wide field of view for detecting the angular position of a remote laser. A laser beam directed toward the sensor from any position within a 90 degree circular field-of-view can be detected to a positional accuracy of less than 0.1 degree in a two-axis coordinate system. The system utilizes two parallel sensors having field-of-view optics that compress the field-of-view. The compressed output from each optics is directed through a polarizer and filter to a phase shifter. The phase shifter, a pair of birefringent crystals, encodes the angle of incidence of the laser beam as a phase shift between the two components of the polarized input beam. These components, the e-ray and the o-ray travel different paths through the phase shifter. Subsequently, an analyzer such as a Wollaston prism decomposes the beam into two linear components. These components are condensed through a reimager lens and coupled to a pair of intensity detectors. The detector outputs from each sensor can then be combined to provide a normalized signal proportional to a trigonometric function of the angle of incidence of the laser beam, indicative of its position in space.

摘要翻译： 一种用于观察宽视野的激光位置传感器系统，用于检测远程激光器的角位置。 可以在双轴坐标系中检测到从90度圆形视野内的任何位置朝向传感器的激光束到小于0.1度的位置精度。 该系统利用具有压缩视场的视场光学器件的两个并行传感器。 来自每个光学器件的压缩输出被引导通过偏振器和滤波器到移相器。 移相器（一对双折射晶体）将激光束的入射角编码为偏振输入光束的两个分量之间的相移。 这些组件，e-ray和o-ray通过移相器传播不同的路径。 随后，诸如Wollaston棱镜的分析仪将光束分解成两个线性分量。 这些组件通过再成像镜头被冷凝并耦合到一对强度检测器。 然后可以组合来自每个传感器的检测器输出，以提供与激光束的入射角的三角函数成比例的归一化信号，表示其在空间中的位置。

公开(公告)号：US20130105231A1

公开(公告)日：2013-05-02

申请号：US13286355

申请日：2011-11-01

申请人： James J. Oakes ,  Prakash K. Mirchandani ,  Gabriel B. Collins ,  Oladapo O. Eso ,  John L. Johnson

发明人： James J. Oakes ,  Prakash K. Mirchandani ,  Gabriel B. Collins ,  Oladapo O. Eso ,  John L. Johnson

IPC分类号： E21B10/36

CPC分类号： C22C29/067 ,  B22F2005/001 ,  B22F2998/00 ,  E21B10/5673 ,  C22C29/08

摘要： An earth boring cutting insert including a cemented carbide comprising metal carbide grains dispersed in a metallic binder including at least one of platinum, palladium, rhenium, rhodium, and ruthenium. Also disclosed is an earth boring bit such as, for example, a rotary-cone earth boring bit or a percussion bit, including at least one earth boring cutting insert comprising a cemented carbide including a metallic binder comprising at least one of platinum, palladium, rhenium, rhodium, and ruthenium

摘要翻译： 一种钻孔切削刀片，其包括硬质合金，其包含分散在包含铂，钯，铼，铑和钌中的至少一种的金属粘合剂中的金属碳化物颗粒。 还公开了一种钻孔钻头，例如旋转圆锥钻孔钻头或冲击钻头，其包括至少一个钻孔切削刀片，其包括包含金属粘结剂的硬质合金，所述金刚石粘合剂包括铂，钯， 铼，铑和钌

公开(公告)号：US06774996B2

公开(公告)日：2004-08-10

申请号：US10171570

申请日：2002-06-11

申请人： John L. Johnson

发明人： John L. Johnson

IPC分类号： G01J400

CPC分类号： G01N21/23

摘要： A method and an apparatus for measuring the density variations, static and dynamic, in substances that are at least partially transparent to electromagnetic waves is disclosed. A special birefringement crystal phase shifting assembly encodes the angle of incidence resulting from the refractive effects of the electromagnetic waves having passed through a density variation. The angle of incidence is encoded as a poralization phase shift. Specifically, the poralization phase shift is between the ordinary and the extraordinary rays. That poralization phase shift has a known and definable relationship to the gas density experienced by the electromagnetic wave during its path.

摘要翻译： 公开了一种用于测量对电磁波至少部分透明的物质中的静态和动态密度变化的方法和装置。 特殊的双折射晶体相移组件对通过密度变化的电磁波的折射效应产生的入射角进行编码。 入射角被编码为电化相移。 具体来说，通化相移在普通和非凡光线之间。 该通化相移与其在其路径中的电磁波所经历的气体密度具有已知和可定义的关系。

公开(公告)号：US06344596B1

公开(公告)日：2002-02-05

申请号：US09367087

申请日：1999-09-15

申请人： William H. Velander ,  William N. Drohan ,  Henryk Lubon ,  John L. Johnson

发明人： William H. Velander ,  William N. Drohan ,  Henryk Lubon ,  John L. Johnson

IPC分类号： A01K67027

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/108 ,  A01K2267/01 ,  A01K2267/03 ,  A61K38/36 ,  C12N9/644 ,  C12Y304/21022

摘要： Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5′-untranslated and 3′-untranslated region, which is substituted with a 5′- and 3′-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described.

摘要翻译： 可以在掺入根据本发明的嵌合DNA分子的转基因动物的乳中获得以高百分比的活性蛋白为特征的重组因子IX。 本发明的转基因动物通过引入编码因子IX的发育中的胚胎DNA而产生，使得外源DNA稳定地并入成熟动物的种系细胞的DNA中。 使用含有乳腺特异性启动子的嵌合构建体，缺乏5'和非翻译区的完整或任何部分的因子IX cDNA完成了特别有效的表达，该5'和3'非翻译区用5'和3' -end的小鼠乳清酸性蛋白基因。 还描述了从本发明的转基因哺乳动物移出的细胞的体外细胞培养物和从所述培养物生产因子IX的方法和治疗血友病B的方法。