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公开(公告)号：US08633303B2
公开(公告)日：2014-01-21
申请号：US13165609
申请日：2011-06-21
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
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公开(公告)号：US07728117B2
公开(公告)日：2010-06-01
申请号：US11515343
申请日：2006-09-01
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：USRE44778E1
公开(公告)日：2014-02-25
申请号：US13484020
申请日：2012-05-30
IPC分类号： C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US20120004190A1
公开(公告)日：2012-01-05
申请号：US13165609
申请日：2011-06-21
IPC分类号： A61K31/7064 , A61K31/7056 , C12Q1/02 , A61P31/00 , G01N21/59 , C07H15/26 , A61P29/00
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US07989601B2
公开(公告)日：2011-08-02
申请号：US12764027
申请日：2010-04-20
IPC分类号： C07H17/04 , C07H15/224 , C07H15/22 , C07H5/04 , A61K31/715
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US20090036386A1
公开(公告)日：2009-02-05
申请号：US11920499
申请日：2006-05-24
IPC分类号： A61K31/7042 , C07H17/04
CPC分类号： C07H17/04 , C07H19/056
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂包括与化合物连接的糖模拟物，例如称为BASAs的化合物类别（苄基氨基 磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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7.发明申请GLYCOMIMETIC INHIBITORS OF THE PA-IL LECTIN, PA-IIL LECTIN OR BOTH THE LECTINS FROM PSEUDOMONAS 有权PA-IL LECTIN，PA-IIL LECTIN或来自PSEUDOMONAS的胶囊的GLYCOMIMETIC INHIBITORS公开(公告)号：US20100041626A1
公开(公告)日：2010-02-18
申请号：US12370826
申请日：2009-02-13
IPC分类号： A61K31/715 , C08B37/00 , A61P31/04
CPC分类号： C07H17/04 , C07H3/06 , G01N33/56911 , G01N2333/21
摘要： Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
摘要翻译： 提供了与假单胞菌属相关的组合物和方法。 组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。 这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。 可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。 通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。
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8.发明申请GLYCOMIMETIC INHIBITORS OF THE PA-IL LECTIN, PA-IIL LECTIN OR BOTH THE LECTINS FROM PSEUDOMONAS 审中-公开PA-IL LECTIN，PA-IIL LECTIN或来自PSEUDOMONAS的胶囊的GLYCOMIMETIC INHIBITORS公开(公告)号：US20120329755A1
公开(公告)日：2012-12-27
申请号：US13566522
申请日：2012-08-03
IPC分类号： C08B37/00 , A61P31/04 , A61K31/702
CPC分类号： C07H17/04 , C07H3/06 , G01N33/56911 , G01N2333/21
摘要： Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
摘要翻译： 提供了与假单胞菌属相关的组合物和方法。 组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。 这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。 可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。 通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。
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9.发明授权Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas 有权PA-IL凝集素，PA-IIL凝集素或来自假单胞菌的凝集素的两者的模拟抑制剂公开(公告)号：US07517980B2
公开(公告)日：2009-04-14
申请号：US11501464
申请日：2006-08-08
IPC分类号： C07H3/06 , A61K31/702 , C07H3/02
CPC分类号： C07H17/04 , C07H3/06 , G01N33/56911 , G01N2333/21
摘要： Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
摘要翻译： 提供了与假单胞菌属相关的组合物和方法。 组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。 这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。 可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。 通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。
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公开(公告)号：US20080161546A1
公开(公告)日：2008-07-03
申请号：US11973891
申请日：2007-10-09
申请人： Beat Ernst , Daniel Schwizer , Arun K. Sarkar , John L. Magnani
发明人： Beat Ernst , Daniel Schwizer , Arun K. Sarkar , John L. Magnani
CPC分类号： C07H15/207
摘要： Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
摘要翻译： 提供了获得寡糖模拟物的化合物和方法。 更具体地，描述了通过在环己烷衍生物中引入或取代而获得寡糖模拟物的化合物和方法。
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