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公开(公告)号：US08633303B2
公开(公告)日：2014-01-21
申请号：US13165609
申请日：2011-06-21
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
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公开(公告)号：US07728117B2
公开(公告)日：2010-06-01
申请号：US11515343
申请日：2006-09-01
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：USRE44778E1
公开(公告)日：2014-02-25
申请号：US13484020
申请日：2012-05-30
IPC分类号： C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US20120004190A1
公开(公告)日：2012-01-05
申请号：US13165609
申请日：2011-06-21
IPC分类号： A61K31/7064 , A61K31/7056 , C12Q1/02 , A61P31/00 , G01N21/59 , C07H15/26 , A61P29/00
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US07989601B2
公开(公告)日：2011-08-02
申请号：US12764027
申请日：2010-04-20
IPC分类号： C07H17/04 , C07H15/224 , C07H15/22 , C07H5/04 , A61K31/715
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。
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公开(公告)号：US07790473B2
公开(公告)日：2010-09-07
申请号：US10578405
申请日：2003-11-05
IPC分类号： G01N33/547 , G01N33/543 , G01N33/24 , G01N33/548
CPC分类号： A61K49/0052 , A61K39/0011 , A61K49/0058 , A61K49/0067 , A61K2039/55555 , B82Y5/00
摘要： Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.
摘要翻译： 新的生物功能化量子点包括连接到纳米晶核的表面的巯基链烷酸和连接到表面的生物官能团。 生物功能化的量子点是通过新的合成方法制得的。 生物功能化量子点可用于成像或治疗应用。
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公开(公告)号：US20090286220A1
公开(公告)日：2009-11-19
申请号：US12437291
申请日：2009-05-07
IPC分类号： A01N1/02
CPC分类号： A01N1/0221
摘要： A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixture between about 75 mole percent to 95 mole percent. The method includes pressurizing the biological tissue, preferably isothermically, with the mixture to a pressure that will form clathrates inside the biological tissue at a desired storage temperature in a range of about +1° C. to about +5° C. The method includes a step of cooling the biological tissue, preferably isobarically, to the desired storage temperature. Optional steps for further cooling to no colder than about −20° C. and for depressurization are provided as well as steps for recovering the hypothermically preserved biological tissue to a viable state, preferably using a recovery gas mixture.
摘要翻译： 生物组织的低温保存方法以便稍后恢复到可行状态包括用六氟化硫或氙气和氧气的混合物冲洗生物组织。 六氟化硫或氙的混合浓度为约75摩尔％至95摩尔％。 该方法包括将生物组织，优选等温地加压至在约+ 1℃至约+ 5℃的范围内的所需储存温度下将在生物组织内形成包合物的压力。该方法包括 将生物组织，优选地等温地冷却至所需的储存温度的步骤。 提供进一步冷却至不低于约-20℃并用于减压的可选步骤，以及用于将低温保存的生物组织回收至可行状态的步骤，优选使用回收气体混合物。
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公开(公告)号：US08124329B2
公开(公告)日：2012-02-28
申请号：US12437291
申请日：2009-05-07
IPC分类号： A01N1/00
CPC分类号： A01N1/0221
摘要： A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixture between about 75 mole percent to 95 mole percent. The method includes pressurizing the biological tissue, preferably isothermically, with the mixture to a pressure that will form clathrates inside the biological tissue at a desired storage temperature in a range of about +1° C. to about +5° C. The method includes a step of cooling the biological tissue, preferably isobarically, to the desired storage temperature. Optional steps for further cooling to no colder than about −20° C. and for depressurization are provided as well as steps for recovering the hypothermically preserved biological tissue to a viable state, preferably using a recovery gas mixture.
摘要翻译： 生物组织的低温保存方法以便稍后恢复到可行状态包括用六氟化硫或氙气和氧气的混合物冲洗生物组织。 六氟化硫或氙的混合浓度为约75摩尔％至95摩尔％。 该方法包括将生物组织，优选等温地加压至在约+ 1℃至约+ 5℃的范围内的所需储存温度下将在生物组织内形成包合物的压力。该方法包括 将生物组织，优选地等温地冷却至所需的储存温度的步骤。 提供进一步冷却至不低于约-20℃并用于减压的可选步骤，以及用于将低温保存的生物组织回收至可行状态的步骤，优选使用回收气体混合物。
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