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    Methods for treating bone tumors
    1.
    发明申请
    Methods for treating bone tumors 审中-公开
    治疗骨肿瘤的方法

    公开(公告)号：US20070249535A1

    公开(公告)日：2007-10-25

    申请号：US11715233

    申请日：2007-03-06

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/00 ,  A61P35/00

    CPC分类号： A61K38/1875 ,  A61K48/00

    摘要： The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

    摘要翻译： 本发明提供了通过施用药学有效量的骨形态发生蛋白或编码骨的核酸来治疗骨癌，诱导骨肿瘤细胞的分化，抑制骨肿瘤生长，诱导骨肿瘤消退或治疗过度增殖性细胞病症的方法 形态发生蛋白。

    Compositions and therapeutic methods using morphogenic proteins
    3.
    发明申请
    Compositions and therapeutic methods using morphogenic proteins 审中-公开
    使用形态发生蛋白的组合物和治疗方法

    公开(公告)号：US20070066525A1

    公开(公告)日：2007-03-22

    申请号：US11499775

    申请日：2006-08-03

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1875

    摘要： The present invention provides pharmaceutical compositions comprising at least two morphogenic proteins, particularly those belonging to the BMP protein family. This invention also provides implantable morphogenic devices comprising a first morphogenic protein and a second morphogenic protein combination disposed within a carrier, that are capable of inducing tissue formation. Methods for inducing local tissue formation from a progenitor cell in a mammal using those compositions and devices are also provided. Methods for improving the tissue inductive activity in a mammal at a target locus using the morphogenic proteins, nucleic acids encoding them, vectors comprising the nucleic acids encoding them and cells comprising the vectors are also provided.

    摘要翻译： 本发明提供包含至少两种形态发生蛋白质的药物组合物，特别是属于BMP蛋白质家族的那些。 本发明还提供了可植入形态发生装置，其包含第一形态发生蛋白和布置在载体内的能够诱导组织形成的第二形态发生蛋白组合。 还提供了使用这些组合物和装置从哺乳动物的祖细胞诱导局部组织形成的方法。 还提供了使用形态发生蛋白，编码它们的核酸，包含编码它们的核酸的载体和包含载体的细胞来改善哺乳动物在靶基因座处的组织诱导活性的方法。

    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
    7.
    发明申请
    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 审中-公开

    公开(公告)号：US20060111298A1

    公开(公告)日：2006-05-25

    申请号：US11332656

    申请日：2006-01-13

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： A61K9/0024 ,  A61K31/726 ,  A61K38/17 ,  A61K38/30 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.