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    Methods for treating bone tumors
    1.
    发明申请
    Methods for treating bone tumors 审中-公开
    治疗骨肿瘤的方法

    公开(公告)号：US20070249535A1

    公开(公告)日：2007-10-25

    申请号：US11715233

    申请日：2007-03-06

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/00 ,  A61P35/00

    CPC分类号： A61K38/1875 ,  A61K48/00

    摘要： The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

    摘要翻译： 本发明提供了通过施用药学有效量的骨形态发生蛋白或编码骨的核酸来治疗骨癌，诱导骨肿瘤细胞的分化，抑制骨肿瘤生长，诱导骨肿瘤消退或治疗过度增殖性细胞病症的方法 形态发生蛋白。

    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
    5.
    发明申请
    Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 审中-公开

    公开(公告)号：US20060111298A1

    公开(公告)日：2006-05-25

    申请号：US11332656

    申请日：2006-01-13

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： A61K9/0024 ,  A61K31/726 ,  A61K38/17 ,  A61K38/30 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

    Compositions and therapeutic methods using morphogenic proteins
    6.
    发明申请
    Compositions and therapeutic methods using morphogenic proteins 审中-公开
    使用形态发生蛋白的组合物和治疗方法

    公开(公告)号：US20070066525A1

    公开(公告)日：2007-03-22

    申请号：US11499775

    申请日：2006-08-03

    申请人： John Lee ,  Lee-Chuan Yeh

    发明人： John Lee ,  Lee-Chuan Yeh

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1875

    摘要： The present invention provides pharmaceutical compositions comprising at least two morphogenic proteins, particularly those belonging to the BMP protein family. This invention also provides implantable morphogenic devices comprising a first morphogenic protein and a second morphogenic protein combination disposed within a carrier, that are capable of inducing tissue formation. Methods for inducing local tissue formation from a progenitor cell in a mammal using those compositions and devices are also provided. Methods for improving the tissue inductive activity in a mammal at a target locus using the morphogenic proteins, nucleic acids encoding them, vectors comprising the nucleic acids encoding them and cells comprising the vectors are also provided.

    摘要翻译： 本发明提供包含至少两种形态发生蛋白质的药物组合物，特别是属于BMP蛋白质家族的那些。 本发明还提供了可植入形态发生装置，其包含第一形态发生蛋白和布置在载体内的能够诱导组织形成的第二形态发生蛋白组合。 还提供了使用这些组合物和装置从哺乳动物的祖细胞诱导局部组织形成的方法。 还提供了使用形态发生蛋白，编码它们的核酸，包含编码它们的核酸的载体和包含载体的细胞来改善哺乳动物在靶基因座处的组织诱导活性的方法。

    Processing method to convert oily sticky byproducts into dry products with animal blood
    9.
    发明申请
    Processing method to convert oily sticky byproducts into dry products with animal blood 审中-公开
    将油性粘性副产物转化为含有动物血液的干性产品的加工方法

    公开(公告)号：US20160302445A1

    公开(公告)日：2016-10-20

    申请号：US14690118

    申请日：2015-04-17

    申请人： John Lee

    发明人： John Lee

    IPC分类号： A23K1/04

    CPC分类号： A23K40/00 ,  A23K10/24 ,  A23K20/158 ,  A23K40/30 ,  A23K40/35 ,  A23K50/10 ,  A23L29/275

    摘要： A processing method to convert oily sticky food byproducts into non-oily and non-sticky dry products by using liquid animal blood is provided. Moisture in the food byproducts is reduced for reducing drying cost and pH is adjusted to 4-10 with preferred range at 6-8, then liquid animal blood is mixed, heated to above 65° C. for coagulation to form non-oily and non-sticky wet products after removing free water. Then related drying equipment is used to produce the non-oily and non-sticky dry products. The non-oily and non-sticky dry products are in particle or fine form with good flowability. The dry products are easy to be stored, transported and applied, which are used in food and feed industries. Besides general feed applications, the non-oily and non-sticky dry products have bypass function for ruminants.

    摘要翻译： 提供了一种通过使用液体动物血液将油状粘性食物副产品转化成非油性和非粘性干燥产品的加工方法。 减少食品副产品中的水分以降低干燥成本，并将pH调节至4-10，优选范围为6-8，然后将液体动物血液混合，加热至65℃以上以凝结形成非油性和非油性 去除自由水后粘稠的湿产品。 然后使用相关的干燥设备生产非油性和非粘性干燥产品。 非油性和非粘性干燥产品具有良好流动性的颗粒或微细形式。 干燥产品易于储存，运输和应用，用于食品和饲料行业。 除了一般的饲料应用，非油性和非粘性干燥产品具有反刍动物的旁路功能。

    Open communication method in a heterogeneous network
    10.
    发明授权
    Open communication method in a heterogeneous network 有权
    在异构网络中开放通信方式

    公开(公告)号：US08792492B2

    公开(公告)日：2014-07-29

    申请号：US13275057

    申请日：2011-10-17

    申请人： Wai Chen ,  Ratul Guha ,  John Lee ,  Junichiro Fukuyama ,  Rama Vuyyuru

    发明人： Wai Chen ,  Ratul Guha ,  John Lee ,  Junichiro Fukuyama ,  Rama Vuyyuru

    IPC分类号： H04L12/28

    CPC分类号： H04W40/06 ,  H04L45/02 ,  H04L45/741 ,  H04L45/745 ,  H04L49/355 ,  H04L67/12 ,  H04L67/327 ,  H04L69/22 ,  H04W4/025 ,  H04W4/06 ,  H04W4/90 ,  H04W88/04

    摘要： An open communication method between at least two sub-networks using a broker node. Each of the sub-networks has a different routable network addressing scheme. The method comprises receiving a packet for a specific application, the packet includes an application identifier, determining if the packet is to be relayed to another of the at least two sub-networks based upon the application identifier, determining if a node receiving the packet is a broker node, relaying the packet to a broker node if not a broker node and forwarding, by the broker node, the packet to at least one node in another of the at least two sub-networks. The node generating the packet communicates using a first of the at least two sub-networks. A broker node communicates using at least two of the at least two sub-networks via a corresponding routable network addressing schemes for each of the sub-networks.

    摘要翻译： 使用代理节点的至少两个子网络之间的开放通信方法。 每个子网络具有不同的可路由网络寻址方案。 该方法包括接收用于特定应用的分组，分组包括应用标识符，基于应用标识确定分组是否要被中继到至少两个子网络中的另一个，确定接收分组的节点是否是 代理节点，如果不是代理节点，则将所述分组中继到代理节点，并且所述代理节点将所述分组转发到所述至少两个子网络中的另一个中的至少一个节点。 生成分组的节点使用所述至少两个子网中的第一个进行通信。 代理节点通过用于每个子网络的相应的可路由网络寻址方案，使用至少两个子网络中的至少两个进行通信。