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公开(公告)号：US20080009785A1
公开(公告)日：2008-01-10
申请号：US11851956
申请日：2007-09-07
申请人： John Mikszta , John Brittingham , Jason Alarcon , Ronald Pettis , John Dekker
发明人： John Mikszta , John Brittingham , Jason Alarcon , Ronald Pettis , John Dekker
IPC分类号： A61B17/20
CPC分类号： A61K9/0021 , A61B17/205 , A61M37/00 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
摘要翻译： 本发明提供了将物质递送到皮肤中的改进方法。 已经发现，与将物质施加到先前磨损的皮肤相比，与皮肤磨损同时递送诸如核酸，氨基酸，氨基酸衍生物，肽和多肽的物质增强了递送和生物反应。
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2.发明申请Microprotrusion Arrays and Methods for Using Same to Deliver Substances into Tissue 审中-公开微量滴定阵列和使用相同方法将物质输送到组织中的方法公开(公告)号：US20080103434A1
公开(公告)日：2008-05-01
申请号：US11942138
申请日：2007-11-19
申请人： Alexander Lastovich , Jason Alarcon , John Dekker , M. Ishaq Haider , John Mikszta , Frank Martin , Scott O'Connor
发明人： Alexander Lastovich , Jason Alarcon , John Dekker , M. Ishaq Haider , John Mikszta , Frank Martin , Scott O'Connor
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.
摘要翻译： 具有流体保持或引导图案的改进的微冲击磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。 公开了这样的装置的各种构造，包括圆顶形，沟道状，图案化和阶梯状。
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3.发明申请公开(公告)号：US20060047242A1
公开(公告)日：2006-03-02
申请号：US10925670
申请日：2004-08-25
申请人： Phillipe Laurent , John Mikszta , Jason Alarcon
发明人： Phillipe Laurent , John Mikszta , Jason Alarcon
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/7023 , A61M2037/0023 , Y02A50/387
摘要： An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.
摘要翻译： 公开了一种用于将物质输送到皮肤中的用于将物质输送到皮肤中的磨损装置和方法。 还公开了具有盖的磨损装置。 这样的装置和方法可以有效地用于将生物活性物质递送到皮肤中。
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公开(公告)号：US20080065005A1
公开(公告)日：2008-03-13
申请号：US11942019
申请日：2007-11-19
申请人： Phillipe Laurent , John Mikszta , Jason Alarcon
发明人： Phillipe Laurent , John Mikszta , Jason Alarcon
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/7023 , A61M2037/0023 , Y02A50/387
摘要： An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.
摘要翻译： 公开了一种用于将物质输送到皮肤中的用于将物质输送到皮肤中的磨损装置和方法。 还公开了具有盖的磨损装置。 这样的装置和方法可以有效地用于将生物活性物质递送到皮肤中。
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公开(公告)号：US20060121055A1
公开(公告)日：2006-06-08
申请号：US11006086
申请日：2004-12-06
申请人： Robert Campbell , Kevin Dolan , Jason Alarcon , John Mikszta , Wendy Woodley , Sheetal Mehta
发明人： Robert Campbell , Kevin Dolan , Jason Alarcon , John Mikszta , Wendy Woodley , Sheetal Mehta
IPC分类号： A61K39/145 , A61K31/716
CPC分类号： A61K39/145 , A61K31/716 , A61K39/12 , A61K39/39 , A61K2039/555 , A61K2039/55511 , A61K2039/55555 , A61K2039/55583 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , Y02A50/412
摘要： The present invention relates to immunogenic compositions containing an immunogen and a specific combination of two or more traditional excipients. The excipients in the composition act in combination and enhance immune responses to the immunogen from a subject. The combination of excipients may be used as adjuvant in immunogenic compositions, regardless of route or target of delivery. The compositions can be administered, for example, intradermally, epidermally, transdermally, junctionally, nasally, or subcutaneously.
摘要翻译： 本发明涉及含有免疫原和两种或更多种传统赋形剂的特定组合的免疫原性组合物。 组合物中的赋形剂组合起作用并增强对受试者免疫原的免疫应答。 赋形剂的组合可以用作免疫原性组合物中的佐剂，而不考虑途径或递送目标。 组合物可以例如皮内，皮下，经皮，连接，鼻或皮下施用。
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6.发明申请Methods of enhancing immune response in the intradermal compartment and compounds useful thereof 审中-公开增强皮内隔室中的免疫应答的方法及其有用的化合物公开(公告)号：US20050281832A1
公开(公告)日：2005-12-22
申请号：US11006369
申请日：2004-12-06
申请人： Robert Campbell , Kevin Dolan , Jason Alarcon , John Mikszta , Wendy Woodley , Sheetal Mehta
发明人： Robert Campbell , Kevin Dolan , Jason Alarcon , John Mikszta , Wendy Woodley , Sheetal Mehta
CPC分类号： A61K39/39 , A61K31/7048 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55588 , C12N2760/16134 , Y02A50/388 , Y02A50/466
摘要： The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations
摘要翻译： 本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。 本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂，即一旦递送到受试者的皮肤的真皮内隔室，则增强对抗原或免疫原性试剂的免疫应答。 本发明的免疫原性组合物包含赋形剂，其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。 本发明的免疫原性组合物具有增强的功效，因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。 本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答，具有比常规使用的更低剂量的抗原性或免疫原性试剂，并且不需要加强免疫
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公开(公告)号：US20060018877A1
公开(公告)日：2006-01-26
申请号：US11118916
申请日：2005-04-29
申请人： John Mikszta , Jason Alarcon , Cheryl Dean , Andrea Hartley
发明人： John Mikszta , Jason Alarcon , Cheryl Dean , Andrea Hartley
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/55572 , C12N2760/16134
摘要： The present invention relates to methods and devices for administration of vaccines and therapeutic agents into the intradermal layer of the skin. The methods of the present invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery methods, e.g., intramuscular route. Furthermore, the methods of the present invention facilitate induction of an immune response by an amount of vaccine which is otherwise insufficient for inducing an immune response when delivered via conventional vaccine routes, e.g., intramuscular route.
摘要翻译： 本发明涉及将疫苗和治疗剂施用到皮肤真皮层中的方法和装置。 与常规疫苗递送方法（例如肌内途径）相比，本发明的方法引起体液和/或细胞反应增加。 此外，本发明的方法便于通过一定量的疫苗诱导免疫应答，否则疫苗不足以在通过常规疫苗途径（例如肌内途径）递送时诱导免疫应答。
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公开(公告)号：US07731968B2
公开(公告)日：2010-06-08
申请号：US11851956
申请日：2007-09-07
CPC分类号： A61K9/0021 , A61B17/205 , A61M37/00 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
摘要翻译： 本发明提供了将物质递送到皮肤中的改进方法。 已经发现，与将物质施加到先前磨损的皮肤相比，与皮肤磨损同时递送诸如核酸，氨基酸，氨基酸衍生物，肽和多肽的物质增强了递送和生物反应。
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公开(公告)号：US06595947B1
公开(公告)日：2003-07-22
申请号：US09576643
申请日：2000-05-22
IPC分类号： A61M100
CPC分类号： A61K9/0021 , A61B17/205 , A61M37/00 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： A method for delivering a substance to the epidermal tissue of skin. The method involves simultaneously disrupting only the stratum corneum of the skin and delivering the substance to the epidermal tissue of the skin.
摘要翻译： 将物质递送到皮肤表皮组织的方法。 该方法包括同时仅破坏皮肤的角质层并将物质输送到皮肤的表皮组织。
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