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25 条记录 (耗时 0.044 秒)

    Novel compositions and methods for the identification, assessment, prevention, and therapy of human cancers
    2.
    发明申请
    Novel compositions and methods for the identification, assessment, prevention, and therapy of human cancers 审中-公开
    用于鉴定，评估，预防和治疗人类癌症的新型组合物和方法

    公开(公告)号：US20070190550A1

    公开(公告)日：2007-08-16

    申请号：US11634620

    申请日：2006-12-06

    申请人： Natalia Iartchouk ,  Mark Ayers ,  Jeffrey Brown ,  Robert Bast ,  Karen Lu ,  Gordon Mills

    发明人： Natalia Iartchouk ,  Mark Ayers ,  Jeffrey Brown ,  Robert Bast ,  Karen Lu ,  Gordon Mills

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12N5/06 ,  C07K16/30

    CPC分类号： A61K31/337 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57449 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明具有许多“灵敏度标记”。 这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。 本发明还具有许多“电阻标记”。 这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。

    Wood-burning boiler
    7.
    发明申请
    Wood-burning boiler 失效
    燃木锅炉

    公开(公告)号：US20070089733A1

    公开(公告)日：2007-04-26

    申请号：US11583998

    申请日：2006-10-19

    申请人： Robert Bast

    发明人： Robert Bast

    IPC分类号： F23L15/00

    CPC分类号： F23B90/00 ,  F23B1/26 ,  F23B1/34 ,  F23B60/02 ,  F23B80/00 ,  F23L1/02 ,  F23L9/02 ,  F23L15/04 ,  Y02E20/348

    摘要： A wood-burning boiler is provided, comprising a combustion chamber having a first air intake, and being adapted for holding combustible wood. An exhaust chamber is fluidly coupled to the combustion chamber, and is adapted to receive burnt gases from the combustion chamber. A preheat chamber is included, having a second air intake, and the preheat chamber is fluidly coupled to the combustion chamber and is conductively proximate to the exhaust chamber such that the burnt gases in the exhaust chamber heat the air within the preheat chamber prior to the air in the preheat chamber entering the combustion chamber. The boiler also includes a water jacket conductively proximate the combustion chamber.

    摘要翻译： 提供了一种燃木锅炉，其包括具有第一进气口的燃烧室，并且适于容纳可燃木材。 排气室流体地联接到燃烧室，并且适于接收来自燃烧室的燃烧气体。 包括预热室，具有第二空气入口，并且预热室流体地联接到燃烧室并且导电地靠近排气室，使得排气室内的燃烧气体在预热室之前加热预热室内的空气 进入燃烧室的预热室内的空气。 锅炉还包括导电接近燃烧室的水套。

    Biomaker for ovarian and endometrial cancer: hepcidin
    9.
    发明申请
    Biomaker for ovarian and endometrial cancer: hepcidin 审中-公开
    卵巢和子宫内膜癌的生物制剂：铁调素

    公开(公告)号：US20100068724A1

    公开(公告)日：2010-03-18

    申请号：US12381218

    申请日：2009-03-09

    申请人： Eric T. Fung ,  Robert Bast ,  Daniel W. Chan ,  Jin Song ,  Valdimir Podust ,  Zhen Zhang

    发明人： Eric T. Fung ,  Robert Bast ,  Daniel W. Chan ,  Jin Song ,  Valdimir Podust ,  Zhen Zhang

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/6851 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/68 ,  G01N33/74 ,  G01N2500/00

    摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers, including hepcidin, transthyretin and optionally other markers are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

    摘要翻译： 本发明提供了可用于鉴定卵巢癌状态以及患者中子宫内膜癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，已经发现，铁调素是卵巢癌和子宫内膜癌的生物标志物，并且一组生物标志物，包括铁调素，转甲状腺素蛋白和任选的其他标记物可用于将受试者样品分类为卵巢癌或非卵巢癌。 生物标志物可以通过SELDI质谱检测。