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公开(公告)号：US06649599B2
公开(公告)日：2003-11-18
申请号：US10005130
申请日：2001-12-05
IPC分类号： A61K31715
CPC分类号： C12R1/89 , A61K9/205 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , B60R21/272 , B60R2021/2633 , B60R2021/2725 , C06D5/00 , C08B37/003 , C12N5/0068 , C12N2533/70 , C12P19/26 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-&bgr;-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a &bgr;-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
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2.发明授权Methods and compositions for poly-&bgr;-1→4-N-acetylglucosamine cell therapy system 失效聚β-1-> 4-N-乙酰氨基葡萄糖细胞治疗系统的方法和组成公开(公告)号：US06610668B2
公开(公告)日：2003-08-26
申请号：US09866827
申请日：2001-05-29
IPC分类号： A61K31715
CPC分类号： C12R1/89 , A61K9/205 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , B60R21/272 , B60R2021/2633 , B60R2021/2725 , C06D5/00 , C08B37/003 , C12N5/0068 , C12N2533/70 , C12P19/26 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-&bgr;-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a &bgr;-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖以β-1→4构象连接，不含蛋白质，基本上不含单一氨基酸，以及其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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3.发明授权Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine drug delivery 失效聚-β-1-4-N-乙酰葡糖胺药物递送的方法和组合物
公开(公告)号：US5846952A
公开(公告)日：1998-12-08
申请号：US470077
申请日：1995-06-06
CPC分类号： A61K9/205 , A61K47/4823 , A61K47/48769 , A61L15/28 , A61L31/042 , C08B37/003 , C12N5/0068 , C12P19/26 , C12R1/89 , C12N2533/70
摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及可用于药物组合物的纯化的易于制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖糖以β1-> 4构象连接，并且不含蛋白质，基本上不含单一氨基酸以及其它有机和无机污染物 。 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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4.发明授权Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine biological barriers 失效聚-β-1-4-N-乙酰葡糖胺生物屏障的方法和组成
公开(公告)号：US5624679A
公开(公告)日：1997-04-29
申请号：US470083
申请日：1995-06-06
IPC分类号： A61K9/20 , A61K47/48 , A61L15/28 , A61L31/04 , C08B37/08 , C12N5/00 , C12P19/26 , C08L5/08 , A61K31/73
CPC分类号： A61K9/205 , A61K47/4823 , A61K47/48769 , A61L15/28 , A61L31/042 , C08B37/003 , C12N5/0068 , C12P19/26 , C12R1/89 , C12N2533/70
摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及一种纯化的，容易制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖物种。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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公开(公告)号：US20090247738A1
公开(公告)日：2009-10-01
申请号：US12482232
申请日：2009-06-10
IPC分类号： C08B37/00
CPC分类号： C12N5/0068 , A61K9/205 , A61K31/715 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , C06D5/00 , C08B37/003 , C12N2533/70 , C12P19/26 , C12R1/89 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-β-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a β-1→4 conformation, and which in free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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公开(公告)号：US06864245B2
公开(公告)日：2005-03-08
申请号：US10616922
申请日：2003-07-11
IPC分类号： A61K9/20 , A61K47/48 , A61L15/28 , A61L31/04 , B60R21/01 , B60R21/263 , B60R21/272 , C06D5/00 , C08B37/08 , C12N5/00 , C12P19/26 , A61K31/715
CPC分类号： C12R1/89 , A61K9/205 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , B60R21/272 , B60R2021/2633 , B60R2021/2725 , C06D5/00 , C08B37/003 , C12N5/0068 , C12N2533/70 , C12P19/26 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-β-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in β-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，并且基本上不含单一氨基酸以及其它有机和无机污染物 。 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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7.发明授权Pharmaceutical compositions comprising poly-&bgr;-1→4-N-acetylglucosamine 失效包含聚-β-1→4-N-乙酰葡糖胺的药物组合物公开(公告)号：US06743783B1
公开(公告)日：2004-06-01
申请号：US10007101
申请日：2001-12-06
IPC分类号： A61K31715
CPC分类号： C12N5/0068 , A61K9/205 , A61K31/715 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , C06D5/00 , C08B37/003 , C12N2533/70 , C12P19/26 , C12R1/89 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-&bgr;-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a &bgr;-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖以β-1→4构象连接，不含蛋白质，基本上不含单一氨基酸，以及其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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公开(公告)号：US06686342B2
公开(公告)日：2004-02-03
申请号：US10386893
申请日：2003-03-12
IPC分类号： A61K31715
CPC分类号： C12R1/89 , A61K9/205 , A61K47/61 , A61K47/69 , A61L15/28 , A61L31/042 , B60R21/272 , B60R2021/2633 , B60R2021/2725 , C06D5/00 , C08B37/003 , C12N5/0068 , C12N2533/70 , C12P19/26 , C08L5/08
摘要： The present invention relates to a purified, easily produced poly-&bgr;-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a &bgr;-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸，以及其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。
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9.发明授权Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine chemotherapeutics 失效聚-β-1-4-N-乙酰氨基葡萄糖化学治疗剂的方法和组合物
公开(公告)号：US5635493A
公开(公告)日：1997-06-03
申请号：US471545
申请日：1995-06-06
CPC分类号： A61K9/205 , A61K47/4823 , A61K47/48769 , A61L15/28 , A61L31/042 , C08B37/003 , C12N5/0068 , C12P19/26 , C12R1/89 , C12N2533/70
摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及可用于药物组合物的纯化的易于制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制剂的用途。
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10.发明授权Method of isolating poly-.beta.-1-4-N-acetylglucosamine from microalgal culture 失效从微藻培养物中分离聚-β-1-N-N-乙酰氨基葡萄糖的方法
公开(公告)号：US5622834A
公开(公告)日：1997-04-22
申请号：US160569
申请日：1993-12-01
IPC分类号： A61K9/20 , A61K31/722 , A61K36/02 , A61K47/48 , A61L31/04 , A61P7/04 , C08B37/08 , C12P19/26 , A61K31/73
CPC分类号： C12R1/89 , A61K47/48769 , A61K9/205 , A61L31/042 , C08B37/003 , C12P19/26
摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
摘要翻译： 本发明涉及一种纯化的，容易制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖物种。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制剂的用途。
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