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23 条记录 (耗时 0.021 秒)

    Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
    1.
    发明授权
    Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules 失效
    使用氮氧化物与生物相容性大分子组合的组合物和方法

    公开(公告)号：US5824781A

    公开(公告)日：1998-10-20

    申请号：US483283

    申请日：1995-06-07

    申请人： Jen-Chang Hsia

    发明人： Jen-Chang Hsia

    IPC分类号： A61K38/00 ,  A61K38/38 ,  A61K38/42 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K49/00 ,  A61K49/20 ,  C07K14/76 ,  C07K14/805 ,  C07K16/00 ,  A61K31/27

    CPC分类号： A61K38/38 ,  A61K38/42 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48015 ,  A61K47/48307 ,  A61K47/48738 ,  A61K47/48769 ,  A61K49/0002 ,  A61K49/20 ,  A61K9/127 ,  B82Y5/00 ,  C07K14/76 ,  C07K14/805 ,  C07K16/00

    摘要： Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. Formulations are described herein that interact with free radicals, acting as antioxidant enzyme-mimics, which preserve nitroxides in their active form in vivo. Applications are described including blood substitutes, radioprotective agents, imaging agents, agents to protect against ischemia and reperfusion injury, and in vivo enzyme mimics among others.

    摘要翻译： 基于与生理上相容的大分子结合使用的氮氧化物，公开了减轻自由基毒性的组合物和方法。 特别地，描述了基于血红蛋白的红细胞替代物，其特征在于稳定的氮氧自由基用于无细胞血红蛋白溶液，包封的血红蛋白溶液，稳定的血红蛋白溶液，聚合血红蛋白溶液，共轭血红蛋白溶液，氮氧自由基标记的白蛋白和氮氧化物标记 免疫球蛋白。 本文描述了与自由基相互作用的制剂，其作为抗氧化酶模拟物，其在体内保护其活性形式的氮氧化物。 描述了应用，包括血液代用品，放射防护剂，成像剂，防止缺血和再灌注损伤的药剂，以及体内酶模拟物等。

    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine chemotherapeutics
    4.
    发明授权
    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine chemotherapeutics 失效
    聚-β-1-4-N-乙酰氨基葡萄糖化学治疗剂的方法和组合物

    公开(公告)号：US5635493A

    公开(公告)日：1997-06-03

    申请号：US471545

    申请日：1995-06-06

    申请人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    发明人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    IPC分类号： A61K9/20 ,  A61K47/48 ,  A61L15/28 ,  A61L31/04 ,  C08B37/08 ,  C12N5/00 ,  C12P19/26 ,  A61K31/73

    CPC分类号： A61K9/205 ,  A61K47/4823 ,  A61K47/48769 ,  A61L15/28 ,  A61L31/042 ,  C08B37/003 ,  C12N5/0068 ,  C12P19/26 ,  C12R1/89 ,  C12N2533/70

    摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

    摘要翻译： 本发明涉及可用于药物组合物的纯化的易于制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制剂的用途。

    Method of isolating poly-.beta.-1-4-N-acetylglucosamine from microalgal culture
    5.
    发明授权
    Method of isolating poly-.beta.-1-4-N-acetylglucosamine from microalgal culture 失效
    从微藻培养物中分离聚-β-1-N-N-乙酰氨基葡萄糖的方法

    公开(公告)号：US5622834A

    公开(公告)日：1997-04-22

    申请号：US160569

    申请日：1993-12-01

    申请人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    发明人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    IPC分类号： A61K9/20 ,  A61K31/722 ,  A61K36/02 ,  A61K47/48 ,  A61L31/04 ,  A61P7/04 ,  C08B37/08 ,  C12P19/26 ,  A61K31/73

    CPC分类号： C12R1/89 ,  A61K47/48769 ,  A61K9/205 ,  A61L31/042 ,  C08B37/003 ,  C12P19/26

    摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

    摘要翻译： 本发明涉及一种纯化的，容易制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖物种。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制剂的用途。

    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine drug delivery
    7.
    发明授权
    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine drug delivery 失效
    聚-β-1-4-N-乙酰葡糖胺药物递送的方法和组合物

    公开(公告)号：US5846952A

    公开(公告)日：1998-12-08

    申请号：US470077

    申请日：1995-06-06

    申请人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    发明人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    IPC分类号： A61K9/20 ,  A61K47/48 ,  A61L15/28 ,  A61L31/04 ,  C08B37/08 ,  C12N5/00 ,  C12P19/26 ,  A61K31/73

    CPC分类号： A61K9/205 ,  A61K47/4823 ,  A61K47/48769 ,  A61L15/28 ,  A61L31/042 ,  C08B37/003 ,  C12N5/0068 ,  C12P19/26 ,  C12R1/89 ,  C12N2533/70

    摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

    摘要翻译： 本发明涉及可用于药物组合物的纯化的易于制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖糖以β1-> 4构象连接，并且不含蛋白质，基本上不含单一氨基酸以及其它有机和无机污染物 。 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。

    Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
    9.
    发明授权
    Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules 失效
    使用氮氧化物与生物相容性大分子组合的组合物和方法

    公开(公告)号：US5807831A

    公开(公告)日：1998-09-15

    申请号：US482951

    申请日：1995-06-07

    申请人： Jen-Chang Hsia

    发明人： Jen-Chang Hsia

    IPC分类号： A61K38/00 ,  A61K38/38 ,  A61K38/42 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K49/00 ,  A61K49/20 ,  C07K14/76 ,  C07K14/805 ,  C07K16/00 ,  A61K31/04

    CPC分类号： A61K38/38 ,  A61K38/42 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48015 ,  A61K47/48307 ,  A61K47/48738 ,  A61K47/48769 ,  A61K49/0002 ,  A61K49/20 ,  A61K9/127 ,  B82Y5/00 ,  C07K14/76 ,  C07K14/805 ,  C07K16/00

    摘要： Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. Formulations are described herein that interact with free radicals, acting as antioxidant enzymemimics, which preserve nitroxides in their active form in vivo. Applications are described including blood substitutes, radioprotective agents, imaging agents, agents to protect against ischemia and reperfusion injury, and in vivo enzyme mimics among others.

    摘要翻译： 基于与生理上相容的大分子结合使用的氮氧化物，公开了减轻自由基毒性的组合物和方法。 特别地，描述了基于血红蛋白的红细胞替代物，其特征在于稳定的氮氧自由基用于无细胞血红蛋白溶液，包封的血红蛋白溶液，稳定的血红蛋白溶液，聚合血红蛋白溶液，共轭血红蛋白溶液，氮氧自由基标记的白蛋白和氮氧化物标记 免疫球蛋白。 本文描述了与自由基相互作用的制剂，其作为抗氧化酶酶学，其在体内保护其活性形式的氮氧化物。 描述了应用，包括血液代用品，放射防护剂，成像剂，防止缺血和再灌注损伤的药剂，以及体内酶模拟物等。