公开(公告)号：US4713372A

公开(公告)日：1987-12-15

申请号：US796139

申请日：1985-11-08

申请人： John P. Schaumberg ,  Gerard C. Hokanson ,  James C. French ,  Josefino B. Tunac ,  Marjorie A. Underhill

发明人： John P. Schaumberg ,  Gerard C. Hokanson ,  James C. French ,  Josefino B. Tunac ,  Marjorie A. Underhill

IPC分类号： C07H19/052 ,  C12P19/38 ,  A61K31/70 ,  C07H17/02

CPC分类号： C12R1/01 ,  C07H19/052 ,  C12P19/38

摘要： 2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.

摘要翻译： 2'-Chloropostostatin是腺苷脱氨酶的有效抑制剂，并且具有用作增强抗病毒剂用于治疗DNA病毒活性的药剂的用途，所述药物含有腺嘌呤部分，例如9-（β-D-阿拉伯糖基） 腺嘌呤 还公开了一种能够产生2'-氯生物素抑制素的命名为ATCC 39365的放线菌纯化菌株，通过需氧发酵生产2'-氯生物素抑制素的方法，以及包含2'-氯磷酸内酯的药物组合物。

公开(公告)号：US4918100A

公开(公告)日：1990-04-17

申请号：US763577

申请日：1985-08-08

申请人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

发明人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

IPC分类号： C07D309/22 ,  C07D309/32 ,  C12P17/06

CPC分类号： C12R1/01 ,  C07D309/22 ,  C07D309/32 ,  C12P17/06

摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties.The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound.The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957B。 抗微生物化合物CL-1957B是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957B化合物，然后分离该化合物。 还公开了抗生素化合物CL-1957B及其药学上可接受的盐，包含该物质的药物组合物和药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

公开(公告)号：US4554162A

公开(公告)日：1985-11-19

申请号：US607056

申请日：1984-05-04

申请人： Cynthia A. Young ,  John P. Schaumberg ,  Gerard C. Hokanson ,  James C. French ,  Josefino B. Tunac

发明人： Cynthia A. Young ,  John P. Schaumberg ,  Gerard C. Hokanson ,  James C. French ,  Josefino B. Tunac

IPC分类号： C07G11/00 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07H11/00 ,  C12P1/06 ,  C12R1/03

CPC分类号： C07H11/00 ,  C12P1/06

摘要： A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.

摘要翻译： 放线菌菌株NRRL 15758能够在需氧发酵的条件下在可同化的碳源和氮源的情况下生产化合物的CL-1724复合物。 表现出抗微生物和抗肿瘤活性的化合物CL-1724B-2与使用这些药物组合物的哺乳动物中治疗微生物感染和肿瘤的药物组合物和方法一起是要求的。

公开(公告)号：US4771070A

公开(公告)日：1988-09-13

申请号：US912684

申请日：1986-09-26

申请人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

发明人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

IPC分类号： C07D309/22 ,  C12P17/06 ,  A61K31/365 ,  C07D309/38

CPC分类号： C07D309/22 ,  C12P17/06

摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生也具有抗肿瘤性质的抗微生物化合物CL-1957A。 抗微生物化合物CL-1957A是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957A化合物，然后分离出CL-1957A化合物。 还公开了抗生素化合物CL-1957A和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

公开(公告)号：US4539203A

公开(公告)日：1985-09-03

申请号：US670240

申请日：1984-11-13

申请人： Alex J. Brankiewicz ,  Richard H. Bunge ,  James C. French ,  Gerard C. Hokanson ,  Timothy R. Hurley ,  John P. Schaumberg

发明人： Alex J. Brankiewicz ,  Richard H. Bunge ,  James C. French ,  Gerard C. Hokanson ,  Timothy R. Hurley ,  John P. Schaumberg

IPC分类号： C07G11/00 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C12P1/06 ,  C12R1/03

CPC分类号： C12P1/06

摘要： Compounds CL-1577D and CL-1577E are prepared by cultivation of a purified isolate of Actinomycete designated ATCC 39363 in a culture medium having assimilable sources of carbon and nitrogen. The compounds are effective antimicrobial agents and possess cytotoxic activity against L1210 murine leukemia cells and P388 murine leukemia cells.

摘要翻译： 化合物CL-1577D和CL-1577E通过在具有可吸收碳源和氮源的培养基中培养称为ATCC 39363的放线菌的纯化分离物来制备。 这些化合物是有效的抗微生物剂，对L1210鼠白血病细胞和P388鼠白血病细胞具有细胞毒活性。