-
1.发明申请SUBSTITUTED 2-AMINOTETRALIN DERIVATIVES AS SELECTIVE ALPHA 2B AGONIST 有权取代的2-氨基嘌呤衍生物作为选择性ALPHA 2B AGONIST公开(公告)号：US20090176845A1
公开(公告)日：2009-07-09
申请号：US11971828
申请日：2008-01-09
申请人： John R. Cappietto , Dario G. Gomez , Ken Chow , Michael E. Garst , Daniel W. Gil , Larry A. Wheeler
发明人： John R. Cappietto , Dario G. Gomez , Ken Chow , Michael E. Garst , Daniel W. Gil , Larry A. Wheeler
IPC分类号： A61K31/4402 , C07D213/04 , A61P25/00 , A61P29/00
CPC分类号： C07D213/38
摘要： Substituted 2-aminotetralin derivatives as selective alpha 2B agonists includes a compound represented by Formula 1: wherein R1═H, methyl, ethyl, propyl, or cyclobutyl; R2=methyl or H; R3=pyridinyl X═C or O. The compounds of Formula 1 can be incorporated in a pharmaceutical compositions and can be used in methods of treating an alpha 2B receptor mediated diseases or conditions.
摘要翻译： 作为选择性α2B激动剂的取代的2-氨基四氢萘衍生物包括由式1表示的化合物：其中R 1 -H，甲基，乙基，丙基或环丁基; R2 =甲基或H; R3 =吡啶基X-C或O.式1的化合物可以掺入药物组合物中，并且可以用于治疗α2B受体介导的疾病或病症的方法。
-
2.发明授权公开(公告)号：US07829587B2
公开(公告)日：2010-11-09
申请号：US11971828
申请日：2008-01-09
申请人： John R. Cappiello , Dario G. Gomez , Ken Chow , Michael E. Garst , Daniel W. Gil , Larry A. Wheeler
发明人： John R. Cappiello , Dario G. Gomez , Ken Chow , Michael E. Garst , Daniel W. Gil , Larry A. Wheeler
IPC分类号： C07D213/04 , A61K31/4402
CPC分类号： C07D213/38
摘要： Substituted 2-aminotetralin derivatives as selective alpha 2B agonists can be incorporated in a pharmaceutical composition and can be used in methods of treating an alpha 2B receptor mediated diseases or conditions. The compounds are represented by Formula 1: wherein R1=H, methyl, ethyl, propyl, or cyclobutyl; R2=methyl or H; R3=pyridinyl X=C or O.
摘要翻译： 作为选择性α2B激动剂的取代的2-氨基四氢萘衍生物可以掺入药物组合物中，并且可以用于治疗α2B受体介导的疾病或病症的方法。 化合物由式1表示：其中R1 = H，甲基，乙基，丙基或环丁基; R2 =甲基或H; R3 =吡啶基X = C或O.
-
公开(公告)号：US06841684B2
公开(公告)日：2005-01-11
申请号：US09815362
申请日：2001-03-21
申请人： Ken Chow , Daniel W. Gil , James A. Burke , Dale A. Harcourt , Michael E. Garst , Larry A. Wheeler , Stephen A. Munk , Dario G. Gomez , Todd M. Heidelbaugh
发明人： Ken Chow , Daniel W. Gil , James A. Burke , Dale A. Harcourt , Michael E. Garst , Larry A. Wheeler , Stephen A. Munk , Dario G. Gomez , Todd M. Heidelbaugh
IPC分类号： C07D233/58 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/435 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/538 , A61P1/12 , A61P7/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/16 , A61P43/00 , C07D233/06 , C07D233/10 , C07D233/54 , C07D233/64 , C07D233/84 , C07D263/28 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/12 , C07D495/04
CPC分类号： C07D233/56 , C07D233/06 , C07D233/10 , C07D233/64 , C07D233/84 , C07D263/28 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/12 , C07D495/04
摘要： Methods and compounds for the treatment of conditions including pain, particularly chronic pain, glaucoma or elevated intraocular pressure with reduced cardiovascular or sedative side effects. Also included are methods of making and using such compounds.
摘要翻译： 用于治疗包括疼痛，特别是慢性疼痛，青光眼或升高的眼内压，降低心血管或镇静剂副作用的病症的方法和化合物。 还包括制备和使用这些化合物的方法。
-
公开(公告)号：US08071636B2
公开(公告)日：2011-12-06
申请号：US12479129
申请日：2009-06-05
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
IPC分类号： A01N43/50 , A61K31/415 , C07D233/00
CPC分类号： A61K31/4168
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性和慢性疼痛的类型。
-
公开(公告)号：US08329918B2
公开(公告)日：2012-12-11
申请号：US12828429
申请日：2010-07-01
申请人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
发明人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
IPC分类号： C07D263/28 , A61K31/42
CPC分类号： C07D277/18 , C07D263/28
摘要： Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclosed.
摘要翻译： 本文描述的是可用作α2B / 2C受体激动剂的化合物。 还公开了包括目前描述的化合物的药物组合物和用目前描述的化合物治疗疾病和病症的方法。
-
6.发明申请公开(公告)号：US20120165380A1
公开(公告)日：2012-06-28
申请号：US13275029
申请日：2011-10-17
申请人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： A61K31/4168 , A61P29/00 , A61P25/00 , C07D233/48
CPC分类号： A61K31/40 , A61K9/0053 , A61K31/4168 , A61K31/4174 , C07D233/48 , C07D233/50
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性，神经性和慢性疼痛的类型。
-
公开(公告)号：US09034910B2
公开(公告)日：2015-05-19
申请号：US13275029
申请日：2011-10-17
申请人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： A61K31/4174 , A61K31/4168 , C07D233/48 , C07D233/50
CPC分类号： A61K31/40 , A61K9/0053 , A61K31/4168 , A61K31/4174 , C07D233/48 , C07D233/50
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性，神经性和慢性疼痛的类型。
-
8.发明申请公开(公告)号：US20120035235A1
公开(公告)日：2012-02-09
申请号：US13274471
申请日：2011-10-17
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
IPC分类号： A61K31/4168 , A61P29/00 , A61P25/00 , C07D233/44
CPC分类号： A61K31/4168
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性和慢性疼痛的类型。
-
公开(公告)号：US20110028523A1
公开(公告)日：2011-02-03
申请号：US12828429
申请日：2010-07-01
申请人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
发明人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
IPC分类号： A61K31/426 , C07D263/28 , A61K31/421 , C07D277/18 , A61P27/06 , A61P25/02 , A61P25/30 , A61P9/00 , A61P3/10 , A61P3/04 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P27/02 , A61P19/02 , A61P1/00 , A61P17/06
CPC分类号： C07D277/18 , C07D263/28
摘要： Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclosed.
摘要翻译： 本文描述的是可用作α2B / 2C受体激动剂的化合物。 还公开了包括目前描述的化合物的药物组合物和用目前描述的化合物治疗疾病和病症的方法。
-
10.发明授权4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists 失效作为α2肾上腺素能激动剂的4-（杂芳基 - 甲基和取代的杂芳基 - 甲基） - 咪唑-2-硫酮公开(公告)号：US07399868B2
公开(公告)日：2008-07-15
申请号：US11232323
申请日：2005-09-20
申请人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
发明人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
IPC分类号： C07D233/42 , C07D403/06 , C07D209/04 , C07D209/02 , C07D487/04
CPC分类号： C07D471/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06
摘要： Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
摘要翻译： 变量具有本说明书中定义的含义的式1化合物是α2肾上腺素能受体的激动剂。 本公开内容的若干化合物优先于α2A2肾上腺素能受体是特异性或选择性的α2B2和/或α2C2N2肾上腺素能受体。 另外一些所要求保护的化合物没有或只有最小的血管内和/或镇静作用。 式1的化合物可用作哺乳动物（包括人）中用作治疗疾病的药物和/或缓解通过α2肾上腺素能受体的激动剂治疗的病症。 没有明显的心血管和/或镇静作用的式1化合物可用于治疗疼痛和其他具有最小副作用的病症。
-
-
-
-
-
-
-
-
-
搜索结果
186 条记录 (耗时 0.05 秒)
