摘要:
A system and method allows a consumer to purchase goods and services from merchants and redeem offers made by a merchant with a digital transaction on a smart phone. The merchant receives and enters the consumer's telephone number into an application. The consumer's telephone number is sent to a server, which checks for electronic coupons and loyalty points. Accounting for the value of any coupon/accumulated loyalty points, the merchant enters the payment amount into the application. which. in turn sends it back to the server. The server then sends the payment amount, any coupon details and the merchant's name to the consumer's phone. The consumer can choose to accept or decline the sale with or without using the coupon/loyalty points. A PIN number confirms the sale, which transmits to the server and then to the merchant. A digital sales receipt is sent to the merchant and consumer.
摘要:
A multi-application payment system and method operates in a hybrid closed/open manner. The multi-application payment system and method features a smart card wherein funds are added to the card at point of sale (POS) locations. The card keeps track of the available balance and is used to purchase goods/services at any POS location. During a transaction, the POS location verifies the amount of funds available and then debits the funds available on the card. Transactions between the card and the POS location are preformed in a substantially closed manner. The POS location then transfers data about the transaction (preferably in a batch manner) to a central processing system. The central processing system processes the data in a generally open manner to move funds to the appropriate account, preferably using the Federal ACH interface.
摘要:
Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要:
Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
An oil well blowout preventer includes a radially compressible annular packing having radially-sectored end portions in a housing having axially aligned upper and lower bores communicating with the inner bore of the packing and with the sectored ends, and also includes hydraulic means for radially constricting the packing, thereby causing it to axially expand. A plurality of circumferentially-arranged rigid wedge members carried by the sectored end portions are individually movable radially into the bores to control the axial expansion whereby radial sectors of the packing may move sequentially inward to effect a seal between the upper and lower bores in response to progressive axial expansion of the packing as the packing undergoes nonuniform sector-wise radial compression. The inward radial movement of the rigid members are limited by stops to a common radial position independent of the uniformity of the radial compression. The blowout preventer effects a seal between the inner bore and the upper and lower bores regardless of the presence of an oil well tool therein.
摘要:
Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6 and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译:式(I)的化合物,其中R 1,R 2,R 3,R 4,R 4, R 5和R 6如本文对式(IA)和式(IB)所定义,或其互变异构体,前药,溶剂合物或其盐; 含有这些化合物的药物组合物,以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法,或其特征在于使用这些化合物的患者的炎症,过敏或增殖过程。
摘要:
This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z1 represents a direct bond R1 may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, —SO2NR4R5, —NR4SO2R5, —NR4R5, —C(═O)R5, —C(═O)C(═O)R5, —C(═O)NR4R5, —C(═O)OR5, —O(C═O)NR4R5, or —NR4C(═O)R5; R3 represents —C(=Z)—N(R7)R6, —C(=Z)—CHR12R6, —C(=Z)—R6, —CR8═C(R9)(CH2)p—R6, —C(R10)═C(R11)R12, —C(R13)(R10)C(R11)(R14)R12, —C(R8)(R15)CH(R9)(CH2)p—R6, —R6, —N(R16)C(=Z)R6, —C(R17)═N—OC(=0)R18, —C(═O)—N(R19)OR20, —C≡C—R6, —CH2—C(=Z)—R6, —C(=Z)—C(=Z)R6, —CH2—NHR6, —CH2-ZR6, —CH2—SOR6, —CH2—SO2R6, —CF2—OR6, —NH—CH2R6, -Z-CH2R6, —SO—CH2R6, —SO2—CH2R6, —O—CF2R6, —O—C(=Z)R6, —N═N—R6, —NH—SO2R6, —SO2—NR21R22, —CZ-CZ-NHR6, —NH—CO—OR6, —O—CO—NHR6, —NH—CO—NHR6, —R23, —CX1═CX2R6, —C(═NOR24), —(CH2)qR6, —CH2—CO—NH(CH2)qR6, —CH2—NH—CO(CH2)qR6, —CH2—CO—CH2R6, —C(═NR25)—NH(CH2)qR6, —C(X3)═N—(CH2)qR6 or —CH(X4)—CH2R6; A1 represents a direct bond, or a straight or branched C1-6 alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A1 represents a straight or branched C2-6alkenylene or C2-6alkynylene chain; Z1 represents a direct bond, an oxygen or sulphur atom or NH; n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译:本发明涉及式(I)的生理活性化合物,其中代表双环体系,约10至约13个环成员,其中该环是氮杂环,并且该环代表氮杂杂芳基环,或任选地被卤素取代 苯环; R 1表示氢或1至约4个碳原子的直链或支链烷基,任选被羟基或一个或多个卤素原子取代,或当Z 1表示直接键R 1时 也代表低级烯基或低级炔基或甲酰基; R 2表示氢,烯基,烷氧基,烷基,烷基亚磺酰基,烷基磺酰基,烷硫基,芳基,芳基烷氧基,芳基烷基亚磺酰基,芳基烷基磺酰基,芳基烷硫基,芳氧基,芳基亚磺酰基,芳基磺酰基,芳硫基,氰基,环烯基,环烯氧基,环烷基,环烷氧基,杂芳基, ,杂芳氧基,羟基,-SO 2 NR 4 R 5,-NR 4 SO 2 R 5,-NR 4 R 5,-C(= O)R 5,-C(= O)C(= O)R 5,-C(= O)NR 4 R 5,-C(= O)OR 5,-O(C = O)NR 4 R 5或-NR 4 C(= O)R 5; R 3表示-C(= Z)-N(R 7)R 6,-C(= Z)-CHR 12 R 6,-C(= Z)-R 6 ,-CR 8 = C(R 9)(CH 2)p R 6,-C(R 10)= C(R 11)R 12,-C(R 13) (R 10)C(R 11)(R 14)R 12,-C(R 8)(R 15)CH(R 9)(CH 2) pR 6,-R 6,-N(R 16)C(= Z)R 6,-C(R 17)= N-OC(= O)R 18, -C(= O)-N(R <19)
摘要:
Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
A system and method for transaction processing includes a central repository of transaction information which can be accessed by a variety of participants who may be located over a wide geographic area in the recovery process of a property unit such as a vehicle or other collateral. Interfacing with a variety of computer systems over a communication network, such as the Internet, allows interchange of data relating to the recovery process and centralized coordination of the recovery process.
摘要:
An improvement in blowout preventer apparatus of the type having a radially compressible annular packing mounted within a housing chamber, the housing having axially aligned upper and lower conical bores communicating with an inner bore of the annular packing, the packing axially expanding towards said upper and lower bores upon said radial compression, a plurality of rigid end ring segments attached to sectored webs of the ends of the packing and thereby individually movable axially outwardly and radially inwardly relative to the upper and lower conical bores to control the packing axial expansion during radial compression of the packing has keying means cooperating with the rigid end ring segments of the packing and the conical bores for guiding a sector-wise movement of the segments in individually separate and predetermined paths along the conical bores to a common radial position independent of the uniformity of the packing radial compression and/or axial expansion. Exemplary keying means include a key member provided in a slot in the packing end ring segment and a mating keyway in the conical bore.