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公开(公告)号：US06821111B2
公开(公告)日：2004-11-23
申请号：US10449551
申请日：2003-05-30
IPC分类号： B29C4520
CPC分类号： B29C45/2701 , B29C45/2708 , B29K2021/00
摘要： The present invention is directed towards the hybrid combination of a drop gate injection molding system and a lattice gate. The lattice gate is located prior to the orifice of the drop gate. The lattice gate is comprised of a series of cross-direction flow channels through which the rubber flows, with mixing of the rubbers at the intersections of the flow channels. This hybrid molding system permits shorter cure times, and improved process cycle time for curing rubbers.
摘要翻译： 本发明涉及液滴栅注射成型系统和格栅的混合组合。 格栅门位于滴浇口的孔口之前。 格栅由一系列横向流动通道组成，橡胶流过该通道，橡胶在流动通道的交点处混合。 该混合成型系统允许较短的固化时间，并且改善固化橡胶的工艺循环时间。
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公开(公告)号：US06796786B2
公开(公告)日：2004-09-28
申请号：US10638912
申请日：2003-08-11
IPC分类号： B29C4518
CPC分类号： B29C45/2701 , B01F5/0645 , B01F2215/0049 , B29K2021/00 , B29K2075/00
摘要： The present invention is directed to the structure of an inline runner for injection molding which uniformly increases the temperature of the injected compound as the compound flows from the injection port to single or multiple drop gates at the entrance to single or multiple injection mold cavities. The inline runner has two opposing series of parallel channels formed into the runner for the purpose of mixing the compound as it flows through the runner.
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公开(公告)号：US06607688B1
公开(公告)日：2003-08-19
申请号：US09658087
申请日：2000-09-08
IPC分类号： B29C4500
CPC分类号： B29C45/2701 , B29C45/2708 , B29K2021/00
摘要： The present invention is directed towards the hybrid combination of a drop gate injection molding system and a lattice gate. The lattice gate is located prior to the orifice of the drop gate. The lattice gate is comprised of a series of cross-direction flow channels through which the rubber flows, with mixing of the rubbers at the intersections of the flow channels. This hybrid molding system permits shorter cure times, and improved process cycle time for curing rubbers.
摘要翻译： 本发明涉及液滴栅注射成型系统和格栅的混合组合。 格栅门位于滴浇口的孔口之前。 格栅由一系列横向流动通道组成，橡胶流过该通道，橡胶在流动通道的交点处混合。 该混合成型系统允许较短的固化时间，并且改善固化橡胶的工艺循环时间。
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公开(公告)号：US06379603B1
公开(公告)日：2002-04-30
申请号：US09445522
申请日：1999-12-07
IPC分类号： B29C4500
CPC分类号： B29C45/2701 , B29K2021/00
摘要： The present invention relates to a lattice gate for directing streams of rubber into an injection molding device through a plurality of intersecting channels (78, 80) which thermally mix the streams of rubber within the gate (76) as they pass through the intersections of the flow channels permitting the injection time of the rubber into the mold cavity to be decreased while simultaneously reducing the time for curing the rubber within the mold.
摘要翻译： 本发明涉及一种用于通过多个相交通道（78,80）将橡胶流引导到注射成型装置中的格栅门，当通过门（76）的交叉点 允许橡胶进入模腔的注射时间的流动通道减少，同时减少在模具内固化橡胶的时间。
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公开(公告)号：US5916891A
公开(公告)日：1999-06-29
申请号：US481671
申请日：1995-06-07
IPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07F9/6506 , C07F9/6558 , A61K31/505
CPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07F9/65062 , C07F9/65583
摘要： Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
摘要翻译： 新型2,4,5-三芳基咪唑化合物和用于治疗的组合物。
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公开(公告)号：US5686455A
公开(公告)日：1997-11-11
申请号：US256500
申请日：1994-11-30
IPC分类号： A61K31/4164 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/10 , A61P37/00 , A61P37/06 , A61P43/00 , C07D233/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/435
CPC分类号： C07D401/04 , C07D403/04 , C07D413/14
摘要： As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.
摘要翻译： PCT No.PCT / US93 / 00674 Sec。 371日期1994年11月30日 102（e）1994年11月30日PCT PCT 1993年1月13日PCT公布。 公开号WO93 / 14081 日期1997年7月22日作为细胞因子抑制剂2,4,5-三芳基咪唑化合物和用作细胞因子抑制剂的组合物。
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公开(公告)号：US20120095193A1
公开(公告)日：2012-04-19
申请号：US13379748
申请日：2010-07-01
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Provided herein are isolated antigen binding protein comprising at least one first immunoglobulin variable domain capable of binding to human ADAMTS5. Also provided are antigen binding proteins of the present invention that are monoclonal antibodies, pharmaceutical compositions comprising said antigen binding proteins and methods of treatment.
摘要翻译： 本文提供了分离的抗原结合蛋白，其包含能够结合人ADAMTS5的至少一个第一免疫球蛋白可变结构域。 还提供了作为单克隆抗体的本发明的抗原结合蛋白，包含所述抗原结合蛋白的药物组合物和治疗方法。
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公开(公告)号：US06290948B1
公开(公告)日：2001-09-18
申请号：US08852212
申请日：1997-05-06
IPC分类号： A61K4505
CPC分类号： A61K38/195 , A61K31/175 , A61K31/546 , A61K31/7036 , Y10S514/885 , Y10S514/921 , A61K2300/00
摘要： The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.
摘要翻译： 本发明涉及使用趋化因子或其生物活性片段单独或与抗感染剂联合预防和治疗败血症和ARDS的方法。
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公开(公告)号：US06268370B1
公开(公告)日：2001-07-31
申请号：US09270866
申请日：1999-03-16
IPC分类号： A61K31505
CPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07F9/6506 , C07F9/65583
摘要： Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
摘要翻译： 新型2,4,5-三芳基咪唑化合物和用于治疗的组合物
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公开(公告)号：US20120315267A1
公开(公告)日：2012-12-13
申请号：US13577923
申请日：2011-02-09
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
IPC分类号： A61K39/395 , C12N15/63 , A61P19/02 , A61P11/06 , A61P9/10 , A61P1/00 , A61P1/04 , A61P37/06 , A61P35/00 , A61P11/00 , C12N5/10 , C12N1/19 , C12N1/21 , C12N1/15 , C07K16/00
CPC分类号： C07K16/244 , C07K16/24 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases
摘要翻译： 本发明涉及多种抗原特异性及其在治疗人类疾病中的应用的抗体
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