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公开(公告)号:US20120315267A1
公开(公告)日:2012-12-13
申请号:US13577923
申请日:2011-02-09
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
IPC分类号: A61K39/395 , C12N15/63 , A61P19/02 , A61P11/06 , A61P9/10 , A61P1/00 , A61P1/04 , A61P37/06 , A61P35/00 , A61P11/00 , C12N5/10 , C12N1/19 , C12N1/21 , C12N1/15 , C07K16/00
CPC分类号: C07K16/244 , C07K16/24 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要: The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases
摘要翻译: 本发明涉及多种抗原特异性及其在治疗人类疾病中的应用的抗体
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公开(公告)号:US20110229475A1
公开(公告)日:2011-09-22
申请号:US12596262
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号: A61K39/395 , C07K16/24 , A61P19/02 , A61P9/10 , A61P11/06 , A61P17/06 , C12P21/08 , C12N5/10 , C12N1/00 , C12N5/12 , C12N15/63 , C12P21/02 , A61P19/06 , A61P35/00 , A61P11/00 , A61P7/00 , A61P9/00 , A61P29/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US08496932B2
公开(公告)日:2013-07-30
申请号:US12596262
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号: A61K39/395
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US20080262203A1
公开(公告)日:2008-10-23
申请号:US12103761
申请日:2008-04-16
申请人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人: Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译: 本发明涉及具有多种特异性的抗体。 特别地,本发明的抗体与人IL-8,Gro-α,Gro-β,Gro-γ和ENA-78结合(交叉反应)。
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公开(公告)号:US08362208B2
公开(公告)日:2013-01-29
申请号:US12097279
申请日:2006-12-14
申请人: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译: 本发明涉及NOGO的抗体,含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号:US20100221260A1
公开(公告)日:2010-09-02
申请号:US12097279
申请日:2006-12-14
申请人: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号: A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译: 本发明涉及NOGO的抗体,含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号:US20110014182A1
公开(公告)日:2011-01-20
申请号:US12746837
申请日:2008-12-09
申请人: Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人: Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号: A61K39/395 , C07K14/00 , C07K16/00 , A61P25/28 , A61K38/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要: Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译: 结合β-淀粉样蛋白肽,特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法,其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物,特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症,其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物,包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成,具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号:US20090162358A1
公开(公告)日:2009-06-25
申请号:US12330541
申请日:2008-12-09
申请人: Philippe Marc Louis Alard , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人: Philippe Marc Louis Alard , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号: A61K39/395 , C07K14/47 , C07K16/18 , A61P25/28 , A61P27/06
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要: Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译: 结合β-淀粉样蛋白肽,特别是人β-淀粉样蛋白肽的抗原结合蛋白; 治疗以β-淀粉样蛋白水平升高或β-淀粉样蛋白沉积为特征的疾病或病症的方法,特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症,其特征在于β-淀粉样蛋白水平升高或β-淀粉样蛋白沉积,包括年龄相关性黄斑变性 和青光眼型疾病和β-淀粉样蛋白依赖性白内障形成,具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号:US08921523B2
公开(公告)日:2014-12-30
申请号:US12330541
申请日:2008-12-09
申请人: Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人: Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号: C07K16/46 , C07K16/18 , A61K39/395
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要: Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with the antigen binding proteins; pharmaceutical compositions comprising the antigen binding proteins; and methods of manufacture.
摘要翻译: 结合β-淀粉样蛋白肽,特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法,其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物,特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症,其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物,包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成,与抗原结合蛋白; 包含抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号:US09193784B2
公开(公告)日:2015-11-24
申请号:US13491810
申请日:2012-06-08
申请人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: C07K16/18 , A61K39/395 , A61K39/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译: 结合人和淀粉样蛋白肽的抗体,以所述抗体为特征的疾病或病症的特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物的方法,包含所述抗体的药物组合物和制备方法。
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