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22 条记录 (耗时 0.014 秒)

    POLYNUCLEOTIDE ENCODING AN INTRACELLULAR ESTRADIOL BINDING PROTEIN
    1.
    发明申请
    POLYNUCLEOTIDE ENCODING AN INTRACELLULAR ESTRADIOL BINDING PROTEIN 有权
    编织细胞外结合蛋白的多核苷酸

    公开(公告)号：US20080199931A1

    公开(公告)日：2008-08-21

    申请号：US11939001

    申请日：2007-11-13

    申请人： John S. Adams ,  Hong Chen

    发明人： John S. Adams ,  Hong Chen

    IPC分类号： C12N11/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N1/20

    CPC分类号： C07K14/721

    摘要： Described herein is a novel intracellular estradiol binding protein (“IEBP”), as well as a polynucleotide encoding this protein and various cells and cell lines producing and/or overexpressing it. IEBP is believed to play a role in the modulation of estrogen signaling and in the physiological resistance to the same. Abnormally elevated or decreased levels of IEBP may thus be a component of the etiology of diseases generally correlated with estrogen signaling, such as, by way of example, breast cancer and osteoporosis. Various embodiments of the present invention are believed to provide important tools for developing treatments for these conditions, such as, for example, by providing means for screening therapeutic compounds and identifying a genetic target for therapy.

    摘要翻译： 本文描述的是新型的细胞内雌二醇结合蛋白（“IEBP”），以及编码该蛋白质的多核苷酸以及产生和/或过表达其的各种细胞和细胞系。 IEBP被认为在调节雌激素信号和对其的生理抵抗力方面发挥作用。 因此IEBP异常升高或降低的水平可能是通常与雌激素信号传导相关的疾病的病因学成分，例如乳腺癌和骨质疏松症。 认为本发明的各种实施方案提供了用于开发这些病症治疗的重要工具，例如通过提供筛选治疗化合物和鉴定治疗遗传靶点的方法。

    DEVICE AND METHOD FOR CONTROLLING OPENING OF A VALVE IN AN HVAC SYSTEM
    8.
    发明申请
    DEVICE AND METHOD FOR CONTROLLING OPENING OF A VALVE IN AN HVAC SYSTEM 有权
    控制HVAC系统中阀门开启的装置和方法

    公开(公告)号：US20140083673A1

    公开(公告)日：2014-03-27

    申请号：US13885925

    申请日：2011-10-18

    申请人： Marc Thuillard ,  John S. Adams

    发明人： Marc Thuillard ,  John S. Adams

    IPC分类号： F24F11/04 ,  F24D19/10

    CPC分类号： F24F11/04 ,  F24D19/1015 ,  F24D19/1084 ,  F24F3/06 ,  F24F11/74 ,  F24F11/83

    摘要： For controlling the opening of a valve (10) in an HVAC system (100) to regulate the flow φ of a fluid through a thermal energy exchanger (2) of the HVAC system (100) and adjust the amount of energy E exchanged by the thermal energy exchanger (2), an energy-per-flow gradient (A) is determined, and the opening of the valve (10) is controlled depending on the energy-per-flow gradient (A). The energy-per-flow gradient (A) is determined by measuring at consecutive points in time the flow φ1, φ2 through the valve (10), by determining the amounts of energy E1, E2 exchanged by the thermal energy exchanger (2) at these points in time, and by calculating the energy-per-flow gradient (B) from the flow φ1, φ2 and exchanged energy E1, E2. The energy-per-flow gradient (A) can be determined dynamically and is used as a basis for setting a slope threshold for the thermal energy exchanger (2) so that there is no need to store fixed threshold values.  E  ϕ ( A )  E  ϕ = E 2 - E 1 ϕ 2 - ϕ 1 ( B )

    摘要翻译： 为了控制HVAC系统（100）中的阀（10）的打开以调节流量和流量。 通过HVAC系统（100）的热能交换器（2）的流体并调节由热能交换器（2）交换的能量E，确定每流能量梯度（A），并且 阀（10）的打开根据能量 - 每流量梯度（A）来控制。 通过测量由热能交换器交换的能量E1，E2的量，通过阀（10）在连续的流动时间点测量流量梯度（A） （2）在这些时间点，并通过从流量计算和交换能量E1，E2计算每流量梯度（B）。 可以动态地确定每流量梯度（A），并将其用作设置热能交换器（2）的斜率阈值的基础，使得不需要存储固定的阈值。  （A）; = E 2 - E 1＆phis; 2 - ＆phis; 1（B）

    Intracellular vitamin D binding protein
    9.
    发明授权
    Intracellular vitamin D binding protein 失效
    细胞内维生素D结合蛋白

    公开(公告)号：US06268478B1

    公开(公告)日：2001-07-31

    申请号：US08797358

    申请日：1997-02-11

    申请人： John S. Adams

    发明人： John S. Adams

    IPC分类号： C07K1447

    CPC分类号： C07K14/57 ,  A61K38/00

    摘要： The invention relates to the discovery and purification of novel intracellular vitamin D binding proteins (IDBPs) and the isolation of polynucleotide sequences encoding the proteins. IDBPs are of interest because they mediate the vitamin D resistance, i.e., insensitivity, observed in new world primates. IDBPs are distinct from the vitamin D receptor and other intracellular receptors, e.g. estrogen receptor. One aspect of the invention is to provide purified IDBPs as pharmaceutical compositions to affect steroid hormone activity. Another aspect of the invention provides polynucleotides encoding the IDBPs of the invention for use in altering the expression of IDBPs. Yet another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between IDBP and vitamin D (or other ligands that bind to IDBP), and the use of such compounds as pharmaceutical compositions.

    摘要翻译： 本发明涉及新型细胞内维生素D结合蛋白（IDBPs）的发现和纯化以及编码蛋白质的多核苷酸序列的分离。 IDBPs是有意义的，因为它们介导在新世界灵长类动物中观察到的维生素D抗性，即不敏感性。 IDBPs不同于维生素D受体和其他细胞内受体，例如。 雌激素受体。 本发明的一个方面是提供纯化的IDBPs作为影响类固醇激素活性的药物组合物。 本发明的另一方面提供编码本发明的IDBPs的多核苷酸，用于改变IDBP的表达。 本发明的另一方面是提供用于检测或筛选干扰IDBP和维生素D（或与IDBP结合的其它配体）之间的相互作用的治疗化合物的测定，以及使用这些化合物作为药物组合物。