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1.发明授权Implantable medical device for sensing absolute blood pressure and barometric pressure 失效用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US6024704A
公开(公告)日：2000-02-15
申请号：US70310
申请日：1998-04-30
IPC分类号： A61B5/0215 , A61B5/03 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译： 与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。 在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。 在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。 在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室 压力传感器。 大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。 或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。
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2.发明授权Implantable medical device for sensing absolute blood pressure and barometric pressure 有权用于感测绝对血压和大气压力的植入式医疗装置公开(公告)号：US06234973B1
公开(公告)日：2001-05-22
申请号：US09442855
申请日：1999-11-18
IPC分类号： A61B502
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译： 与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。 在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。 在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。 在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室 压力传感器。 大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。 或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。
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公开(公告)号：US20130192611A1
公开(公告)日：2013-08-01
申请号：US13586572
申请日：2012-08-15
申请人： Robert T. Taepke, II , Ya Guo , Joseph D. Berglund
发明人： Robert T. Taepke, II , Ya Guo , Joseph D. Berglund
IPC分类号： A61B19/00
CPC分类号： A61N1/375 , A61B5/02 , A61B5/021 , A61B5/0215 , A61B5/02152 , A61B5/026 , A61B5/0265 , A61F2/06 , A61F2/07 , A61F2/852 , A61F2013/0094 , A61F2250/003 , A61F2250/0031
摘要： A fixation device configured to anchor an implantable medical device within a patient includes a temporary biodegradable fixation mechanism configured to secure the device after implantation until the temporary fixation mechanism biodegrades and a chronic fixation mechanism configured to promote tissue growth that secures the device to tissue of the patient before the temporary fixation mechanism biodegrades.
摘要翻译： 构造成将可植入医疗装置固定在患者体内的固定装置包括暂时可生物降解的固定机构，其构造成在植入之后固定装置直到临时固定机构生物降解为止，以及构造成促进组织生长的慢性固定机构，其将装置固定到组织 临床固定机制前患者生物降解。
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公开(公告)号：US20120283580A1
公开(公告)日：2012-11-08
申请号：US13099959
申请日：2011-05-03
IPC分类号： A61B5/021
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译： 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标，所述心血管压力信号包括指示至少一个心脏脉搏的定时的至少一个心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
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公开(公告)号：US07963922B2
公开(公告)日：2011-06-21
申请号：US11380710
申请日：2006-04-28
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258 , G06F19/00
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译： 体积消耗的检测，特别是容量过载发生之后。 公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。
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公开(公告)号：US08827913B2
公开(公告)日：2014-09-09
申请号：US13099959
申请日：2011-05-03
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/0215 , A61N1/365
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译： 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标，包括至少一个指示至少一个心脏脉搏的定时的心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
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公开(公告)号：US20100113888A1
公开(公告)日：2010-05-06
申请号：US12261389
申请日：2008-10-30
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译： 通过感测至少一个生理信号来检测心力衰竭失代偿。 使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。 将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。
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公开(公告)号：US07704209B2
公开(公告)日：2010-04-27
申请号：US12369377
申请日：2009-02-11
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译： 提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。 可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。 感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或 脉冲轮廓积分。 脉冲轮廓积分用于估计SV。 估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。
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公开(公告)号：US20090209876A1
公开(公告)日：2009-08-20
申请号：US12369377
申请日：2009-02-11
IPC分类号： A61B5/0402 , A61B5/02
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
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公开(公告)号：US07507208B2
公开(公告)日：2009-03-24
申请号：US12124847
申请日：2008-05-21
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译： 提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。 可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。 感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或 脉冲轮廓积分。 脉冲轮廓积分用于估计SV。 估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。
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