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公开(公告)号：US07963922B2
公开(公告)日：2011-06-21
申请号：US11380710
申请日：2006-04-28
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258 , G06F19/00
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译： 体积消耗的检测，特别是容量过载发生之后。 公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。
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公开(公告)号：US20110251496A1
公开(公告)日：2011-10-13
申请号：US13164145
申请日：2011-06-20
IPC分类号： A61B5/0205
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译： 体积消耗的检测，特别是容量过载发生之后。 公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。
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公开(公告)号：US20100113888A1
公开(公告)日：2010-05-06
申请号：US12261389
申请日：2008-10-30
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译： 通过感测至少一个生理信号来检测心力衰竭失代偿。 使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。 将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。
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公开(公告)号：US08062227B2
公开(公告)日：2011-11-22
申请号：US12261389
申请日：2008-10-30
IPC分类号： A61B5/0215
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译： 通过感测至少一个生理信号来检测心力衰竭失代偿。 使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。 将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。
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公开(公告)号：US20120283580A1
公开(公告)日：2012-11-08
申请号：US13099959
申请日：2011-05-03
IPC分类号： A61B5/021
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译： 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标，所述心血管压力信号包括指示至少一个心脏脉搏的定时的至少一个心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
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公开(公告)号：US08827913B2
公开(公告)日：2014-09-09
申请号：US13099959
申请日：2011-05-03
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/0215 , A61N1/365
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译： 示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。 该系统基于所测量的心血管压力信号确定多个心血管压力指标，包括至少一个指示至少一个心脏脉搏的定时的心血管压力指标。 该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。 所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。
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公开(公告)号：US07704209B2
公开(公告)日：2010-04-27
申请号：US12369377
申请日：2009-02-11
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译： 提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。 可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。 感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或 脉冲轮廓积分。 脉冲轮廓积分用于估计SV。 估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。
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公开(公告)号：US20090209876A1
公开(公告)日：2009-08-20
申请号：US12369377
申请日：2009-02-11
IPC分类号： A61B5/0402 , A61B5/02
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
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公开(公告)号：US07507208B2
公开(公告)日：2009-03-24
申请号：US12124847
申请日：2008-05-21
IPC分类号： A61B5/00
CPC分类号： A61B5/02028 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/0456 , G06F19/00
摘要： A system and method are provided for sensing cardiac electrogram (EGM) signals and ventricular pressure signals and for using the sensed EGM and sensed pressure signals for estimating stroke volume (SV). A measure of cardiac output can be computed from the estimated SV and a heart rate determined from the EGM signals. The sensed ventricular pressure signal and the sensed EGM signal are used to derive landmark points such as an estimated pulmonary diastolic pressure, a mean pulmonary artery pressure, a peak right ventricular pressure (RVP), and various time intervals used in computing an area or a pulse contour integral. The pulse contour integral is used to estimate SV. The estimated pulmonary diastolic pressure, mean pulmonary artery pressure and CO computed from the estimated SV can be used to compute a pulmonary vascular resistance.
摘要翻译： 提供了一种用于感测心电图（EGM）信号和心室压力信号以及使用感测的EGM和感测的压力信号来估计行程量（SV）的系统和方法。 可以从估计的SV和从EGM信号确定的心率计算心输出量的量度。 感测到的心室压力信号和感测到的EGM信号用于导出标记点，例如估计的肺舒张压，平均肺动脉压，右心室压力峰值（RVP）和用于计算区域或 脉冲轮廓积分。 脉冲轮廓积分用于估计SV。 估计的肺舒张压，平均肺动脉压和从估计的SV计算的CO可用于计算肺血管阻力。
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10.发明授权Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权使用可植入医疗装置识别和/或评估心律失常的方法公开(公告)号：US08554315B2
公开(公告)日：2013-10-08
申请号：US13099547
申请日：2011-05-03
IPC分类号： A61B5/0452
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译： 一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。 通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。 所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。 因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。 此外，可以针对每个存储间隔的一个被监视的参数确定中值。 在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。
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